CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice

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De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccin...

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Autores principales: Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R.
Formato: INPR
Lenguaje:English
Materias:
CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0264410X_v_n_p_Ruiz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0264410X_v_n_p_Ruiz
record_format dspace
spelling todo:paper_0264410X_v_n_p_Ruiz2023-10-03T15:12:51Z CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice Ruiz, M.S. Mac Keon, S. Campisano, S. Bravo, A.I. Gazzaniga, S. Wainstok, R. CD207+ cells Dendritic cells Ectopic lymphoid tissue Melanoma Vaccine De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd. All rights reserved. Fil:Gazzaniga, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. INPR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0264410X_v_n_p_Ruiz
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
spellingShingle CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
Ruiz, M.S.
Mac Keon, S.
Campisano, S.
Bravo, A.I.
Gazzaniga, S.
Wainstok, R.
CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
topic_facet CD207+ cells
Dendritic cells
Ectopic lymphoid tissue
Melanoma
Vaccine
description De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd. All rights reserved.
format INPR
author Ruiz, M.S.
Mac Keon, S.
Campisano, S.
Bravo, A.I.
Gazzaniga, S.
Wainstok, R.
author_facet Ruiz, M.S.
Mac Keon, S.
Campisano, S.
Bravo, A.I.
Gazzaniga, S.
Wainstok, R.
author_sort Ruiz, M.S.
title CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_short CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_full CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_fullStr CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_full_unstemmed CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
title_sort cd207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of dc-apo/nec vaccine in mice
url http://hdl.handle.net/20.500.12110/paper_0264410X_v_n_p_Ruiz
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