Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?

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The effects of progesterone in the solution suspending uterine preparations isolated from ovariectomized rats on the output of PGF2α and PGE2-like material, were explored. Uterine incubation for one hour with progesterone (50 or 100 ug/ml, final concentration) did not alter PGF or PGE release into t...

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Autores principales: Gimeno, A.L., Franchi, A.M., González, E.T., Gimeno, M.F.
Formato: JOUR
Materias:
progesterone
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal cell
drug mechanism
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Animal
Castration
Dinoprost
Dinoprostone
Female
In Vitro
Progesterone
Prostaglandins E
Prostaglandins F
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02621746_v14_n2_p289_Gimeno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_02621746_v14_n2_p289_Gimeno
record_format dspace
spelling todo:paper_02621746_v14_n2_p289_Gimeno2023-10-03T15:12:34Z Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal? Gimeno, A.L. Franchi, A.M. González, E.T. Gimeno, M.F. progesterone prostaglandin e prostaglandin e2 prostaglandin f2 alpha animal cell drug mechanism endocrine system female genital system nonhuman ovariectomy rat uterus Animal Castration Dinoprost Dinoprostone Female In Vitro Progesterone Prostaglandins E Prostaglandins F Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uterus The effects of progesterone in the solution suspending uterine preparations isolated from ovariectomized rats on the output of PGF2α and PGE2-like material, were explored. Uterine incubation for one hour with progesterone (50 or 100 ug/ml, final concentration) did not alter PGF or PGE release into the bath medium, when compared with untreated controls. One hour after hormone removal the output of either prostaglandin, from uteri previously primed with progesterone at 50 ug/ml, was also similar to controls. However, preparations exposed to progesterone at 100 ug/ml for one hour and subjected afterwards to a second incubation of interval of 60 minutes without the hormone, released into the suspending medium significantly more PGF, but not PGE, than controls. On the other hand, incubation with progesterone (at 100 ug/ml) for 120 minutes (not followed by a period of steroid removal) failed to change PGF and PGE uterine output. These findings show that there is a direct but complex effect of progesterone on rat uterine release of PGF, i.e., the positive correlation between the steroid and PGF required not only a priming period with a high concentration of progesterone but also its subsequent withdrawal. Such peculiarity is discussed in terms of a possible influence of progesterone on enhancing intramural uterine levels of PGF and inhibiting prostaglandin release, and also in relation to the role of hormone withdrawal after corpora lutea regression on PGF concentration in blood from uterine veins during the sex cycle. © 1984. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02621746_v14_n2_p289_Gimeno
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic progesterone
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal cell
drug mechanism
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Animal
Castration
Dinoprost
Dinoprostone
Female
In Vitro
Progesterone
Prostaglandins E
Prostaglandins F
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
spellingShingle progesterone
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal cell
drug mechanism
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Animal
Castration
Dinoprost
Dinoprostone
Female
In Vitro
Progesterone
Prostaglandins E
Prostaglandins F
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
Gimeno, A.L.
Franchi, A.M.
González, E.T.
Gimeno, M.F.
Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?
topic_facet progesterone
prostaglandin e
prostaglandin e2
prostaglandin f2 alpha
animal cell
drug mechanism
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Animal
Castration
Dinoprost
Dinoprostone
Female
In Vitro
Progesterone
Prostaglandins E
Prostaglandins F
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
description The effects of progesterone in the solution suspending uterine preparations isolated from ovariectomized rats on the output of PGF2α and PGE2-like material, were explored. Uterine incubation for one hour with progesterone (50 or 100 ug/ml, final concentration) did not alter PGF or PGE release into the bath medium, when compared with untreated controls. One hour after hormone removal the output of either prostaglandin, from uteri previously primed with progesterone at 50 ug/ml, was also similar to controls. However, preparations exposed to progesterone at 100 ug/ml for one hour and subjected afterwards to a second incubation of interval of 60 minutes without the hormone, released into the suspending medium significantly more PGF, but not PGE, than controls. On the other hand, incubation with progesterone (at 100 ug/ml) for 120 minutes (not followed by a period of steroid removal) failed to change PGF and PGE uterine output. These findings show that there is a direct but complex effect of progesterone on rat uterine release of PGF, i.e., the positive correlation between the steroid and PGF required not only a priming period with a high concentration of progesterone but also its subsequent withdrawal. Such peculiarity is discussed in terms of a possible influence of progesterone on enhancing intramural uterine levels of PGF and inhibiting prostaglandin release, and also in relation to the role of hormone withdrawal after corpora lutea regression on PGF concentration in blood from uterine veins during the sex cycle. © 1984.
format JOUR
author Gimeno, A.L.
Franchi, A.M.
González, E.T.
Gimeno, M.F.
author_facet Gimeno, A.L.
Franchi, A.M.
González, E.T.
Gimeno, M.F.
author_sort Gimeno, A.L.
title Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?
title_short Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?
title_full Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?
title_fullStr Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?
title_full_unstemmed Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?
title_sort progesterone in vitro and the output of prostaglandin f from the uterus of ovariectomized rats. priming or withdrawal?
url http://hdl.handle.net/20.500.12110/paper_02621746_v14_n2_p289_Gimeno
work_keys_str_mv AT gimenoal progesteroneinvitroandtheoutputofprostaglandinffromtheuterusofovariectomizedratsprimingorwithdrawal
AT franchiam progesteroneinvitroandtheoutputofprostaglandinffromtheuterusofovariectomizedratsprimingorwithdrawal
AT gonzalezet progesteroneinvitroandtheoutputofprostaglandinffromtheuterusofovariectomizedratsprimingorwithdrawal
AT gimenomf progesteroneinvitroandtheoutputofprostaglandinffromtheuterusofovariectomizedratsprimingorwithdrawal
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