Nitroimidazole derivatives: Non-randomness sister chromatid exchanges in human peripheral blood lymphocytes

Nitroimidazole derivatives exhibited genotoxic effect in different experimental conditions. This study focuses on an evaluation of possible genomic targets, at a chromosomal level, of two 5-nitroimidazoles (ornidazole and metronidazole) using the in vitro human peripheral blood culture as experiment...

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Detalles Bibliográficos
Autores principales: Carballo, M.A., Martinez, R.A., Mudry, M.D.
Formato: JOUR
Materias:
Biomarkers
Chromosomal damage
Genomic instability
Genotoxicity
Nitroimidazoles
biological marker
metronidazole
nitroimidazole derivative
ornidazole
adult
article
blood culture
cell proliferation
chromosome
chromosome band
chromosome damage
chromosome size
controlled study
cytotoxicity
drug exposure
female
genome analysis
genomic instability
genotoxicity
human
human cell
human experiment
in vitro study
male
mitosis index
normal human
peripheral lymphocyte
priority journal
sister chromatid exchange
Biological Markers
Cell Division
Cells, Cultured
Chromosome Banding
Dose-Response Relationship, Drug
Female
Humans
Leukocytes, Mononuclear
Male
Metronidazole
Mitotic Index
Mutagenicity Tests
Mutagens
Ornidazole
Sister Chromatid Exchange
Young Adult
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0260437X_v29_n3_p248_Carballo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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