Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia
Recently, we described that serum decreases tritiated mannose incorporation into protein in the chick optic lobe at 18 days of embryonic age (Rossi et al., 1990). In this paper, we found a strikingly different response of this serum effect according to age. The data obtained showed no serum induced...
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todo:paper_01970186_v21_n2_p281_Rossi2023-10-03T15:09:51Z Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia Rossi, S. Vargas, V.I. Carminatti, H. leucine mannose protein amino acid transport animal tissue article blood brain barrier brain injury embryo embryo development gestational age glia cell hatching nerve cell newborn nonhuman optic lobe pathogenesis priority journal serum sugar transport Aging Animal Blood Cells, Cultured Chick Embryo Chickens Culture Media Glucosephosphates Glycoproteins Leucine Mannose Nerve Tissue Proteins Neuroglia Neurons Superior Colliculus Support, Non-U.S. Gov't Tritium Animalia Recently, we described that serum decreases tritiated mannose incorporation into protein in the chick optic lobe at 18 days of embryonic age (Rossi et al., 1990). In this paper, we found a strikingly different response of this serum effect according to age. The data obtained showed no serum induced decrease in 6-10-day-old embryo. In addition, our results demonstrate that the differential response of the tissue to the serum is independent of the rate of sugar entry into nerve cells. Furthermore, we also report that the variation of mannose or leucine incorporation into protein coincides very closely with the pattern of protein and glycoprotein accumulation during chick optic lobe development. Finally, data were obtained to define glial cells as the cellular target of the serum induced effect. This finding may contribute to elucidate the mechanism of cellular pathogenesis of cerebral lesions that occur after the breakdown of the blood brain barrier, such as in some diseases or during bleeding after injuries. © 1992. Fil:Rossi, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Carminatti, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01970186_v21_n2_p281_Rossi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
leucine mannose protein amino acid transport animal tissue article blood brain barrier brain injury embryo embryo development gestational age glia cell hatching nerve cell newborn nonhuman optic lobe pathogenesis priority journal serum sugar transport Aging Animal Blood Cells, Cultured Chick Embryo Chickens Culture Media Glucosephosphates Glycoproteins Leucine Mannose Nerve Tissue Proteins Neuroglia Neurons Superior Colliculus Support, Non-U.S. Gov't Tritium Animalia |
| spellingShingle |
leucine mannose protein amino acid transport animal tissue article blood brain barrier brain injury embryo embryo development gestational age glia cell hatching nerve cell newborn nonhuman optic lobe pathogenesis priority journal serum sugar transport Aging Animal Blood Cells, Cultured Chick Embryo Chickens Culture Media Glucosephosphates Glycoproteins Leucine Mannose Nerve Tissue Proteins Neuroglia Neurons Superior Colliculus Support, Non-U.S. Gov't Tritium Animalia Rossi, S. Vargas, V.I. Carminatti, H. Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia |
| topic_facet |
leucine mannose protein amino acid transport animal tissue article blood brain barrier brain injury embryo embryo development gestational age glia cell hatching nerve cell newborn nonhuman optic lobe pathogenesis priority journal serum sugar transport Aging Animal Blood Cells, Cultured Chick Embryo Chickens Culture Media Glucosephosphates Glycoproteins Leucine Mannose Nerve Tissue Proteins Neuroglia Neurons Superior Colliculus Support, Non-U.S. Gov't Tritium Animalia |
| description |
Recently, we described that serum decreases tritiated mannose incorporation into protein in the chick optic lobe at 18 days of embryonic age (Rossi et al., 1990). In this paper, we found a strikingly different response of this serum effect according to age. The data obtained showed no serum induced decrease in 6-10-day-old embryo. In addition, our results demonstrate that the differential response of the tissue to the serum is independent of the rate of sugar entry into nerve cells. Furthermore, we also report that the variation of mannose or leucine incorporation into protein coincides very closely with the pattern of protein and glycoprotein accumulation during chick optic lobe development. Finally, data were obtained to define glial cells as the cellular target of the serum induced effect. This finding may contribute to elucidate the mechanism of cellular pathogenesis of cerebral lesions that occur after the breakdown of the blood brain barrier, such as in some diseases or during bleeding after injuries. © 1992. |
| format |
JOUR |
| author |
Rossi, S. Vargas, V.I. Carminatti, H. |
| author_facet |
Rossi, S. Vargas, V.I. Carminatti, H. |
| author_sort |
Rossi, S. |
| title |
Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia |
| title_short |
Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia |
| title_full |
Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia |
| title_fullStr |
Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia |
| title_full_unstemmed |
Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: The possible role of glia |
| title_sort |
development modulates the serum induced effect on the incorporation of [2-3h]mannose into chick optic lobe protein: the possible role of glia |
| url |
http://hdl.handle.net/20.500.12110/paper_01970186_v21_n2_p281_Rossi |
| work_keys_str_mv |
AT rossis developmentmodulatestheseruminducedeffectontheincorporationof23hmannoseintochickopticlobeproteinthepossibleroleofglia AT vargasvi developmentmodulatestheseruminducedeffectontheincorporationof23hmannoseintochickopticlobeproteinthepossibleroleofglia AT carminattih developmentmodulatestheseruminducedeffectontheincorporationof23hmannoseintochickopticlobeproteinthepossibleroleofglia |
| _version_ |
1782028664635916288 |