Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid

The effect of BALB/c anti CF1 lymph node cells and thymocytes on the spontaneous activity of isolated CF1 mouse atria was studied. Immune lymph node cells induced opposite effects depending on the number of immunizations. Immune lymph node cells from mice which received two immunizations decreased t...

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Autores principales:	Borda, E., Genaro, A.M., Cremaschi, G., Sales, M.E., Sterin-Borda, L.
Formato:	JOUR
Materias:	7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid dithizone indometacin nordihydroguaiaretic acid animal cell heart heart atrium heart muscle contractility immune response lymph node cell lymphatic system mouse nonhuman priority journal thymocyte thymus Animals Arachidonic Acid Arachidonic Acids Aspirin Catechols Dithizone Indomethacin Lymph Nodes Male Mice Mice, Inbred BALB C Myocardial Contraction Myocardium Nordihydroguaiaretic Acid T-Lymphocytes
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01920561_v6_n6_p629_Borda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_01920561_v6_n6_p629_Borda
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spelling	todo:paper_01920561_v6_n6_p629_Borda2023-10-03T15:09:05Z Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid Borda, E. Genaro, A.M. Cremaschi, G. Sales, M.E. Sterin-Borda, L. 7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid dithizone indometacin nordihydroguaiaretic acid animal cell heart heart atrium heart muscle contractility immune response lymph node cell lymphatic system mouse nonhuman priority journal thymocyte thymus Animals Arachidonic Acid Arachidonic Acids Aspirin Catechols Dithizone Indomethacin Lymph Nodes Male Mice Mice, Inbred BALB C Myocardial Contraction Myocardium Nordihydroguaiaretic Acid T-Lymphocytes The effect of BALB/c anti CF1 lymph node cells and thymocytes on the spontaneous activity of isolated CF1 mouse atria was studied. Immune lymph node cells induced opposite effects depending on the number of immunizations. Immune lymph node cells from mice which received two immunizations decreased the contractile tension of the atrium, whereas, cells from mice exposed to three and five immunizations strongly increased the tension. Immune thymocytes induced only negative inotropic action and this effect did not depend on the number of immunizations. Indeed, it was similar after two, three or five immunizations. Control normal lymph node cells or thymocytes from BALB/c or CF1 mice had no effect on CF1 atria. Furthermore, BALB/c anti CF1 cells had no effect on BALB/c atria. Inhibitors of cyclooxygenase activity prevented the negative inotropic influence of immune thymocytes and lymph node cells seen after two immunizations. In contrast, inhibitors of the lipoxygenase pathway abolished the positive inotropic action induced by lymph node cells obtained after three and five immunizations. Cell-free supernatants of lymph node cells from animals receiving five immunizations, stimulated the contractile activity of atrium, while those from thymocytes inhibited it, indicating that soluble factors are generated by contact of immune cells with the myocardium. It is proposed that upon recognition of alloantigens expressed by atrial cells, lymph node cells and thymocytes are activated and release either arachidonic acid metabolites or some factor(s) that induces this release by other cells, which in turn triggers different effects in myocardial tissue depending on the set of cells involved in the primary immune response. © 1984. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01920561_v6_n6_p629_Borda
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid dithizone indometacin nordihydroguaiaretic acid animal cell heart heart atrium heart muscle contractility immune response lymph node cell lymphatic system mouse nonhuman priority journal thymocyte thymus Animals Arachidonic Acid Arachidonic Acids Aspirin Catechols Dithizone Indomethacin Lymph Nodes Male Mice Mice, Inbred BALB C Myocardial Contraction Myocardium Nordihydroguaiaretic Acid T-Lymphocytes
spellingShingle	7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid dithizone indometacin nordihydroguaiaretic acid animal cell heart heart atrium heart muscle contractility immune response lymph node cell lymphatic system mouse nonhuman priority journal thymocyte thymus Animals Arachidonic Acid Arachidonic Acids Aspirin Catechols Dithizone Indomethacin Lymph Nodes Male Mice Mice, Inbred BALB C Myocardial Contraction Myocardium Nordihydroguaiaretic Acid T-Lymphocytes Borda, E. Genaro, A.M. Cremaschi, G. Sales, M.E. Sterin-Borda, L. Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid
topic_facet	7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid acetylsalicylic acid dithizone indometacin nordihydroguaiaretic acid animal cell heart heart atrium heart muscle contractility immune response lymph node cell lymphatic system mouse nonhuman priority journal thymocyte thymus Animals Arachidonic Acid Arachidonic Acids Aspirin Catechols Dithizone Indomethacin Lymph Nodes Male Mice Mice, Inbred BALB C Myocardial Contraction Myocardium Nordihydroguaiaretic Acid T-Lymphocytes
description	The effect of BALB/c anti CF1 lymph node cells and thymocytes on the spontaneous activity of isolated CF1 mouse atria was studied. Immune lymph node cells induced opposite effects depending on the number of immunizations. Immune lymph node cells from mice which received two immunizations decreased the contractile tension of the atrium, whereas, cells from mice exposed to three and five immunizations strongly increased the tension. Immune thymocytes induced only negative inotropic action and this effect did not depend on the number of immunizations. Indeed, it was similar after two, three or five immunizations. Control normal lymph node cells or thymocytes from BALB/c or CF1 mice had no effect on CF1 atria. Furthermore, BALB/c anti CF1 cells had no effect on BALB/c atria. Inhibitors of cyclooxygenase activity prevented the negative inotropic influence of immune thymocytes and lymph node cells seen after two immunizations. In contrast, inhibitors of the lipoxygenase pathway abolished the positive inotropic action induced by lymph node cells obtained after three and five immunizations. Cell-free supernatants of lymph node cells from animals receiving five immunizations, stimulated the contractile activity of atrium, while those from thymocytes inhibited it, indicating that soluble factors are generated by contact of immune cells with the myocardium. It is proposed that upon recognition of alloantigens expressed by atrial cells, lymph node cells and thymocytes are activated and release either arachidonic acid metabolites or some factor(s) that induces this release by other cells, which in turn triggers different effects in myocardial tissue depending on the set of cells involved in the primary immune response. © 1984.
format	JOUR
author	Borda, E. Genaro, A.M. Cremaschi, G. Sales, M.E. Sterin-Borda, L.
author_facet	Borda, E. Genaro, A.M. Cremaschi, G. Sales, M.E. Sterin-Borda, L.
author_sort	Borda, E.
title	Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid
title_short	Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid
title_full	Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid
title_fullStr	Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid
title_full_unstemmed	Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid
title_sort	variable inotropic effect of immune cells on mice atria - participation of metabolic products of arachidonic acid
url	http://hdl.handle.net/20.500.12110/paper_01920561_v6_n6_p629_Borda
work_keys_str_mv	AT bordae variableinotropiceffectofimmunecellsonmiceatriaparticipationofmetabolicproductsofarachidonicacid AT genaroam variableinotropiceffectofimmunecellsonmiceatriaparticipationofmetabolicproductsofarachidonicacid AT cremaschig variableinotropiceffectofimmunecellsonmiceatriaparticipationofmetabolicproductsofarachidonicacid AT salesme variableinotropiceffectofimmunecellsonmiceatriaparticipationofmetabolicproductsofarachidonicacid AT sterinbordal variableinotropiceffectofimmunecellsonmiceatriaparticipationofmetabolicproductsofarachidonicacid
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Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid

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