Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
Serum prolactin (PRL) and pituitary nuclear estrogen receptors (RnE2) were determined in ovariectomized rats treated with 5 μg/kg estradiol and subjected to single or combined treatment with dopamine (DA) and tamoxifen (TAM). A significative inhibition of serum PRL was observed by DA, TAM, and DA pl...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0172780X_v15_n5-6_p389_Stalldecker |
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todo:paper_0172780X_v15_n5-6_p389_Stalldecker2023-10-03T15:07:37Z Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries Stalldecker, G. Reynoso, R. Piroli, G. Narizano, O.C. De Nicola, A.F. dopamine estradiol estrogen receptor prolactin tamoxifen adenohypophysis animal experiment article controlled study drug receptor binding female hormone inhibition intraperitoneal drug administration nonhuman ovariectomy priority journal prolactin blood level rat Serum prolactin (PRL) and pituitary nuclear estrogen receptors (RnE2) were determined in ovariectomized rats treated with 5 μg/kg estradiol and subjected to single or combined treatment with dopamine (DA) and tamoxifen (TAM). A significative inhibition of serum PRL was observed by DA, TAM, and DA plus TAM treatment. TAM, as well as DA, increased RnE2, but DA reduced the TAM effect when they were administered together. This observation suggests competition for a common binding site on the RnE2 between TAM and DA or by an unknown ligand produced after treatment with DA. The lack of an additive effect on PRL inhibition in the combined treatment indicates that both agents share at least one common inhibitory mechanism for PRL, behaving as antagonists of estrogen action at the receptor level. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0172780X_v15_n5-6_p389_Stalldecker |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
dopamine estradiol estrogen receptor prolactin tamoxifen adenohypophysis animal experiment article controlled study drug receptor binding female hormone inhibition intraperitoneal drug administration nonhuman ovariectomy priority journal prolactin blood level rat |
| spellingShingle |
dopamine estradiol estrogen receptor prolactin tamoxifen adenohypophysis animal experiment article controlled study drug receptor binding female hormone inhibition intraperitoneal drug administration nonhuman ovariectomy priority journal prolactin blood level rat Stalldecker, G. Reynoso, R. Piroli, G. Narizano, O.C. De Nicola, A.F. Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries |
| topic_facet |
dopamine estradiol estrogen receptor prolactin tamoxifen adenohypophysis animal experiment article controlled study drug receptor binding female hormone inhibition intraperitoneal drug administration nonhuman ovariectomy priority journal prolactin blood level rat |
| description |
Serum prolactin (PRL) and pituitary nuclear estrogen receptors (RnE2) were determined in ovariectomized rats treated with 5 μg/kg estradiol and subjected to single or combined treatment with dopamine (DA) and tamoxifen (TAM). A significative inhibition of serum PRL was observed by DA, TAM, and DA plus TAM treatment. TAM, as well as DA, increased RnE2, but DA reduced the TAM effect when they were administered together. This observation suggests competition for a common binding site on the RnE2 between TAM and DA or by an unknown ligand produced after treatment with DA. The lack of an additive effect on PRL inhibition in the combined treatment indicates that both agents share at least one common inhibitory mechanism for PRL, behaving as antagonists of estrogen action at the receptor level. |
| format |
JOUR |
| author |
Stalldecker, G. Reynoso, R. Piroli, G. Narizano, O.C. De Nicola, A.F. |
| author_facet |
Stalldecker, G. Reynoso, R. Piroli, G. Narizano, O.C. De Nicola, A.F. |
| author_sort |
Stalldecker, G. |
| title |
Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries |
| title_short |
Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries |
| title_full |
Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries |
| title_fullStr |
Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries |
| title_full_unstemmed |
Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries |
| title_sort |
effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries |
| url |
http://hdl.handle.net/20.500.12110/paper_0172780X_v15_n5-6_p389_Stalldecker |
| work_keys_str_mv |
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1807324062343495680 |