Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors

In estrogen-induced pituitary tumors, binding of (3H)-dexamethasone (DEX) to soluble glucocorticoid receptors (GCR) was reduced 5-6 fold with respect to normal pituitaries. GCR in the tumors, however, bound normally to DNA-cellulose after heat-induced transformation. In control rats, serum prolactin...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Piroli, G., Grillo, C., Lux de Lantos, V., Libertun, C., De Nicola, A.F.
Formato: JOUR
Materias:
dexamethasone
glucocorticoid receptor
prolactin
animal experiment
animal model
article
controlled study
feedback system
hypophysis tumor
male
nonhuman
priority journal
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0172780X_v13_n2_p75_Piroli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0172780X_v13_n2_p75_Piroli
record_format dspace
spelling todo:paper_0172780X_v13_n2_p75_Piroli2023-10-03T15:07:37Z Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors Piroli, G. Grillo, C. Lux de Lantos, V. Libertun, C. De Nicola, A.F. dexamethasone glucocorticoid receptor prolactin animal experiment animal model article controlled study feedback system hypophysis tumor male nonhuman priority journal rat In estrogen-induced pituitary tumors, binding of (3H)-dexamethasone (DEX) to soluble glucocorticoid receptors (GCR) was reduced 5-6 fold with respect to normal pituitaries. GCR in the tumors, however, bound normally to DNA-cellulose after heat-induced transformation. In control rats, serum prolactin (PRL) increased after ether stress and decreased following DEX treatment, whereas these maneuvres failed to change the hyperprolactinemia of rats with pituitary tumors. Thus, in rats with experimental prolactinomas, impaired negative feedback of serum PRL to DEX seems to correlate with a low content of functional GCR. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0172780X_v13_n2_p75_Piroli
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic dexamethasone
glucocorticoid receptor
prolactin
animal experiment
animal model
article
controlled study
feedback system
hypophysis tumor
male
nonhuman
priority journal
rat
spellingShingle dexamethasone
glucocorticoid receptor
prolactin
animal experiment
animal model
article
controlled study
feedback system
hypophysis tumor
male
nonhuman
priority journal
rat
Piroli, G.
Grillo, C.
Lux de Lantos, V.
Libertun, C.
De Nicola, A.F.
Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors
topic_facet dexamethasone
glucocorticoid receptor
prolactin
animal experiment
animal model
article
controlled study
feedback system
hypophysis tumor
male
nonhuman
priority journal
rat
description In estrogen-induced pituitary tumors, binding of (3H)-dexamethasone (DEX) to soluble glucocorticoid receptors (GCR) was reduced 5-6 fold with respect to normal pituitaries. GCR in the tumors, however, bound normally to DNA-cellulose after heat-induced transformation. In control rats, serum prolactin (PRL) increased after ether stress and decreased following DEX treatment, whereas these maneuvres failed to change the hyperprolactinemia of rats with pituitary tumors. Thus, in rats with experimental prolactinomas, impaired negative feedback of serum PRL to DEX seems to correlate with a low content of functional GCR.
format JOUR
author Piroli, G.
Grillo, C.
Lux de Lantos, V.
Libertun, C.
De Nicola, A.F.
author_facet Piroli, G.
Grillo, C.
Lux de Lantos, V.
Libertun, C.
De Nicola, A.F.
author_sort Piroli, G.
title Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors
title_short Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors
title_full Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors
title_fullStr Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors
title_full_unstemmed Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors
title_sort glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors
url http://hdl.handle.net/20.500.12110/paper_0172780X_v13_n2_p75_Piroli
work_keys_str_mv AT pirolig glucocorticoidreceptorsandinhibitionofserumprolactinbydexamethasonearereducedinratswithestrogeninducedpituitarytumors
AT grilloc glucocorticoidreceptorsandinhibitionofserumprolactinbydexamethasonearereducedinratswithestrogeninducedpituitarytumors
AT luxdelantosv glucocorticoidreceptorsandinhibitionofserumprolactinbydexamethasonearereducedinratswithestrogeninducedpituitarytumors
AT libertunc glucocorticoidreceptorsandinhibitionofserumprolactinbydexamethasonearereducedinratswithestrogeninducedpituitarytumors
AT denicolaaf glucocorticoidreceptorsandinhibitionofserumprolactinbydexamethasonearereducedinratswithestrogeninducedpituitarytumors
_version_ 1807323411534315520

Ejemplares similares