Protein synthesis in polyamine-deficient bacteria during amino-acid starvation
Amino-acid starvation in polyamine-auxotrophic bacteria grown in the presence of putrescine provokes a marked inhibition of protein synthesis. This inhibition is almost completely relieved in polyamine-depleted cells. The differential behaviour of bacterial protein synthesis depending on the endogen...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01674781_v949_n1_p65_Nastri |
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todo:paper_01674781_v949_n1_p65_Nastri2023-10-03T15:04:45Z Protein synthesis in polyamine-deficient bacteria during amino-acid starvation Nastri, H.G. Algranati, I.D. (E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't Amino-acid starvation in polyamine-auxotrophic bacteria grown in the presence of putrescine provokes a marked inhibition of protein synthesis. This inhibition is almost completely relieved in polyamine-depleted cells. The differential behaviour of bacterial protein synthesis depending on the endogenous levels of polyamines is not due to a change in the uptake of amino acids used to measure protein synthesis, nor to the decreased growth rate of polyamine-depleted cells. During leucine starvation, cells grown with putrescine synthesized a somewhat lower amount of high-molecular-weight proteins than polyamine-depleted bacteria. In addition, cells with normal endogenous levels of polyamines accumulated significant amounts of 62 and 41 kDa polypeptides as well as several low-molecular-weight peptides. © 1988. Fil:Nastri, H.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Algranati, I.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01674781_v949_n1_p65_Nastri |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
(E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't |
| spellingShingle |
(E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't Nastri, H.G. Algranati, I.D. Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| topic_facet |
(E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't |
| description |
Amino-acid starvation in polyamine-auxotrophic bacteria grown in the presence of putrescine provokes a marked inhibition of protein synthesis. This inhibition is almost completely relieved in polyamine-depleted cells. The differential behaviour of bacterial protein synthesis depending on the endogenous levels of polyamines is not due to a change in the uptake of amino acids used to measure protein synthesis, nor to the decreased growth rate of polyamine-depleted cells. During leucine starvation, cells grown with putrescine synthesized a somewhat lower amount of high-molecular-weight proteins than polyamine-depleted bacteria. In addition, cells with normal endogenous levels of polyamines accumulated significant amounts of 62 and 41 kDa polypeptides as well as several low-molecular-weight peptides. © 1988. |
| format |
JOUR |
| author |
Nastri, H.G. Algranati, I.D. |
| author_facet |
Nastri, H.G. Algranati, I.D. |
| author_sort |
Nastri, H.G. |
| title |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_short |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_full |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_fullStr |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_full_unstemmed |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_sort |
protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| url |
http://hdl.handle.net/20.500.12110/paper_01674781_v949_n1_p65_Nastri |
| work_keys_str_mv |
AT nastrihg proteinsynthesisinpolyaminedeficientbacteriaduringaminoacidstarvation AT algranatiid proteinsynthesisinpolyaminedeficientbacteriaduringaminoacidstarvation |
| _version_ |
1782028762036043776 |