CRF signaling: molecular specificity for drug targeting in the CNS

Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system response needed to adapt to stress. If adaptation fails, hypersecretion of CRF continues and produces, via CRF type 1 receptors, symptoms pertaining to cognition, appetite, sleep and anxiety, implicating CRF as a...

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Autores principales:	Arzt, E., Holsboer, F.
Formato:	JOUR
Materias:	calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01656147_v27_n10_p531_Arzt
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_01656147_v27_n10_p531_Arzt2023-10-03T15:03:04Z CRF signaling: molecular specificity for drug targeting in the CNS Arzt, E. Holsboer, F. calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system response needed to adapt to stress. If adaptation fails, hypersecretion of CRF continues and produces, via CRF type 1 receptors, symptoms pertaining to cognition, appetite, sleep and anxiety, implicating CRF as a causal factor in affective disorders. Clinical studies with CRF receptor 1 antagonists support a novel pharmacological strategy for treating stress-related disorders. Here we summarize recent information obtained on CRF receptor 1 signaling and propose the concept of a more focused pharmacological intervention based on the signaling pathways involved. Recent findings suggest that CRF activates, via the same CRF receptor 1, different signaling pathways in specific areas of the brain. This intracellular and neuroanatomical signaling specificity will facilitate the search for less pleiotropic antagonists and new chemical compounds that modulate signal transduction in a site-specific manner. © 2006 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01656147_v27_n10_p531_Arzt
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological
spellingShingle	calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological Arzt, E. Holsboer, F. CRF signaling: molecular specificity for drug targeting in the CNS
topic_facet	calcium ion corticotropin releasing factor corticotropin releasing factor receptor 1 cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein membrane associated guanylate cyclase kinase mitogen activated protein kinase nitric oxide synthase phorbol 13 acetate 12 myristate phospholipase C receptor subtype adaptation addiction anxiety disorder brain cell membrane permeability central nervous system depression drug targeting hippocampus human hypothalamus hypophysis adrenal system limbic cortex mental disease mood disorder neuroanatomy neuropharmacology nonhuman priority journal review signal transduction stress Animals Brain Corticotropin-Releasing Hormone Humans Mental Disorders Signal Transduction Stress Stress, Physiological
description	Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system response needed to adapt to stress. If adaptation fails, hypersecretion of CRF continues and produces, via CRF type 1 receptors, symptoms pertaining to cognition, appetite, sleep and anxiety, implicating CRF as a causal factor in affective disorders. Clinical studies with CRF receptor 1 antagonists support a novel pharmacological strategy for treating stress-related disorders. Here we summarize recent information obtained on CRF receptor 1 signaling and propose the concept of a more focused pharmacological intervention based on the signaling pathways involved. Recent findings suggest that CRF activates, via the same CRF receptor 1, different signaling pathways in specific areas of the brain. This intracellular and neuroanatomical signaling specificity will facilitate the search for less pleiotropic antagonists and new chemical compounds that modulate signal transduction in a site-specific manner. © 2006 Elsevier Ltd. All rights reserved.
format	JOUR
author	Arzt, E. Holsboer, F.
author_facet	Arzt, E. Holsboer, F.
author_sort	Arzt, E.
title	CRF signaling: molecular specificity for drug targeting in the CNS
title_short	CRF signaling: molecular specificity for drug targeting in the CNS
title_full	CRF signaling: molecular specificity for drug targeting in the CNS
title_fullStr	CRF signaling: molecular specificity for drug targeting in the CNS
title_full_unstemmed	CRF signaling: molecular specificity for drug targeting in the CNS
title_sort	crf signaling: molecular specificity for drug targeting in the cns
url	http://hdl.handle.net/20.500.12110/paper_01656147_v27_n10_p531_Arzt
work_keys_str_mv	AT arzte crfsignalingmolecularspecificityfordrugtargetinginthecns AT holsboerf crfsignalingmolecularspecificityfordrugtargetinginthecns
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CRF signaling: molecular specificity for drug targeting in the CNS

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