Increased splenocyte proliferative response and cytokine production in β-endorphin-deficient mice

We used β-endorphin-deficient mice as a novel approach to confirm the physiological role that opioid peptides play in the development or regulation of the immune system. We found that mice lacking β-endorphin possessed an enhanced immune response, measured in terms of splenocyte proliferation and in...

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Detalles Bibliográficos
Autores principales: Refojo, D., Kovalovsky, D., Young, J.I., Rubinstein, M., Holsboer, F., Reul, J.M.H.M, Low, M.J., Arzt, E.
Formato: JOUR
Materias:
β-endorphin
Cytokines
HPA axis
Neuroimmunology
Splenocyte
beta endorphin
corticosterone
corticotropin
interleukin 12
interleukin 6
lipopolysaccharide
messenger RNA
tumor necrosis factor alpha
animal cell
animal experiment
animal model
animal tissue
article
cell proliferation
controlled study
corticosterone blood level
corticotropin blood level
cytokine production
immune response
immune system
immunoregulation
macrophage
mouse
nonhuman
priority journal
protein blood level
protein deficiency
spleen cell
Adrenocorticotropic Hormone
Animals
beta-Endorphin
Cell Division
Cells, Cultured
Corticosterone
Interleukin-2
Interleukin-6
Lipopolysaccharides
Mice
Mice, Inbred C57BL
Mice, Knockout
RNA, Messenger
Spleen
Tumor Necrosis Factor-alpha
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01655728_v131_n1-2_p126_Refojo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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