Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice

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Autoimmunity is a feature of celiac disease (CD) with tissue transglutaminase (tTG) as a major autoantigen. A correlation between gynecological-obstetric disorders in CD patients and the presence of circulating antibodies anti-tTG that inhibited tTG activity was reported. Serum anti-tTG antibodies w...

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Autores principales: Sóñora, C., Mourglia-Ettlin, G., Calo, G., Hauk, V., Ramhorst, R., Hernández, A., Leirós, C.P.
Formato: INPR
Lenguaje:English
Materias:
Anti-tissue transglutaminase antibodies
Celiac disease
NOD mice
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01650378_v_n_p_Sonora
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_01650378_v_n_p_Sonora2023-10-03T15:02:40Z Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice Sóñora, C. Mourglia-Ettlin, G. Calo, G. Hauk, V. Ramhorst, R. Hernández, A. Leirós, C.P. Anti-tissue transglutaminase antibodies Celiac disease NOD mice Autoimmunity is a feature of celiac disease (CD) with tissue transglutaminase (tTG) as a major autoantigen. A correlation between gynecological-obstetric disorders in CD patients and the presence of circulating antibodies anti-tTG that inhibited tTG activity was reported. Serum anti-tTG antibodies were detected in a non-obese diabetic (NOD) mouse model of type I insulin-dependent diabetes mellitus and Sjögren's syndrome, two comorbid states with CD. Since pregnancy complications have been described in NOD mice, we evaluated the ability of anti-tTG antibodies to affect the functions of tTG relevant to the normal course of an early pregnancy like extracellular matrix assembling and apoptotic cell phagocytosis by macrophages. Circulating IgG antibodies against tTG were detected in NOD mice with titers that decreased at early pregnancy; interestingly, the in vitro transamidating activity of tTG was reduced by NOD serum samples. Particularly, anti-tTG antibody inhibited apoptotic cell phagocytosis by peritoneal macrophages from pregnant NOD mice that express the enzyme on surface. Evidence provided support for a role for anti-tTG antibodies through reduced transamidating activity and reduced apoptotic cell clearance by the macrophages of pregnant NOD mice. © 2013 Elsevier Ireland Ltd. All rights reserved. Fil:Hauk, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramhorst, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Leirós, C.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. INPR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01650378_v_n_p_Sonora
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic Anti-tissue transglutaminase antibodies
Celiac disease
NOD mice
spellingShingle Anti-tissue transglutaminase antibodies
Celiac disease
NOD mice
Sóñora, C.
Mourglia-Ettlin, G.
Calo, G.
Hauk, V.
Ramhorst, R.
Hernández, A.
Leirós, C.P.
Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
topic_facet Anti-tissue transglutaminase antibodies
Celiac disease
NOD mice
description Autoimmunity is a feature of celiac disease (CD) with tissue transglutaminase (tTG) as a major autoantigen. A correlation between gynecological-obstetric disorders in CD patients and the presence of circulating antibodies anti-tTG that inhibited tTG activity was reported. Serum anti-tTG antibodies were detected in a non-obese diabetic (NOD) mouse model of type I insulin-dependent diabetes mellitus and Sjögren's syndrome, two comorbid states with CD. Since pregnancy complications have been described in NOD mice, we evaluated the ability of anti-tTG antibodies to affect the functions of tTG relevant to the normal course of an early pregnancy like extracellular matrix assembling and apoptotic cell phagocytosis by macrophages. Circulating IgG antibodies against tTG were detected in NOD mice with titers that decreased at early pregnancy; interestingly, the in vitro transamidating activity of tTG was reduced by NOD serum samples. Particularly, anti-tTG antibody inhibited apoptotic cell phagocytosis by peritoneal macrophages from pregnant NOD mice that express the enzyme on surface. Evidence provided support for a role for anti-tTG antibodies through reduced transamidating activity and reduced apoptotic cell clearance by the macrophages of pregnant NOD mice. © 2013 Elsevier Ireland Ltd. All rights reserved.
format INPR
author Sóñora, C.
Mourglia-Ettlin, G.
Calo, G.
Hauk, V.
Ramhorst, R.
Hernández, A.
Leirós, C.P.
author_facet Sóñora, C.
Mourglia-Ettlin, G.
Calo, G.
Hauk, V.
Ramhorst, R.
Hernández, A.
Leirós, C.P.
author_sort Sóñora, C.
title Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
title_short Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
title_full Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
title_fullStr Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
title_full_unstemmed Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
title_sort anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant nod mice
url http://hdl.handle.net/20.500.12110/paper_01650378_v_n_p_Sonora
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AT mourgliaettling antitissuetransglutaminaseantibodyinhibitsapoptoticcellclearancebymacrophagesinpregnantnodmice
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AT leiroscp antitissuetransglutaminaseantibodyinhibitsapoptoticcellclearancebymacrophagesinpregnantnodmice
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