Antifungal terpenoids from Hyalis argentea var. latisquama
A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4)....
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todo:paper_01633864_v77_n7_p1579_Fernandez2023-10-03T15:02:18Z Antifungal terpenoids from Hyalis argentea var. latisquama Fernández, L.R. Butassi, E. Svetaz, L. Zacchino, S.A. Palermo, J.A. Sánchez, M. 8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4). The previously reported compounds included a series of lindenanolides, guaianolides, elemanolides, and additional diterpenes. The antifungal activity of the isolated compounds was tested against Cryptococcus neoformans and Candida albicans. Among the isolated compounds, the lindenanolides were the only structural class that showed strong antifungal activity, and onoseriolide acetate (5) was the most active. On the other hand, the isolated guaianolides were only moderately active, while the diterpenes did not show significant antifungal activity. © 2014 The American Chemical Society and American Society of Pharmacognosy. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v77_n7_p1579_Fernandez |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane |
| spellingShingle |
8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane Fernández, L.R. Butassi, E. Svetaz, L. Zacchino, S.A. Palermo, J.A. Sánchez, M. Antifungal terpenoids from Hyalis argentea var. latisquama |
| topic_facet |
8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane |
| description |
A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4). The previously reported compounds included a series of lindenanolides, guaianolides, elemanolides, and additional diterpenes. The antifungal activity of the isolated compounds was tested against Cryptococcus neoformans and Candida albicans. Among the isolated compounds, the lindenanolides were the only structural class that showed strong antifungal activity, and onoseriolide acetate (5) was the most active. On the other hand, the isolated guaianolides were only moderately active, while the diterpenes did not show significant antifungal activity. © 2014 The American Chemical Society and American Society of Pharmacognosy. |
| format |
JOUR |
| author |
Fernández, L.R. Butassi, E. Svetaz, L. Zacchino, S.A. Palermo, J.A. Sánchez, M. |
| author_facet |
Fernández, L.R. Butassi, E. Svetaz, L. Zacchino, S.A. Palermo, J.A. Sánchez, M. |
| author_sort |
Fernández, L.R. |
| title |
Antifungal terpenoids from Hyalis argentea var. latisquama |
| title_short |
Antifungal terpenoids from Hyalis argentea var. latisquama |
| title_full |
Antifungal terpenoids from Hyalis argentea var. latisquama |
| title_fullStr |
Antifungal terpenoids from Hyalis argentea var. latisquama |
| title_full_unstemmed |
Antifungal terpenoids from Hyalis argentea var. latisquama |
| title_sort |
antifungal terpenoids from hyalis argentea var. latisquama |
| url |
http://hdl.handle.net/20.500.12110/paper_01633864_v77_n7_p1579_Fernandez |
| work_keys_str_mv |
AT fernandezlr antifungalterpenoidsfromhyalisargenteavarlatisquama AT butassie antifungalterpenoidsfromhyalisargenteavarlatisquama AT svetazl antifungalterpenoidsfromhyalisargenteavarlatisquama AT zacchinosa antifungalterpenoidsfromhyalisargenteavarlatisquama AT palermoja antifungalterpenoidsfromhyalisargenteavarlatisquama AT sanchezm antifungalterpenoidsfromhyalisargenteavarlatisquama |
| _version_ |
1807320904137441280 |