7-Hydroxywithanolides from Datura ferox

Three new withanolides were isolated from leaves of Datura ferox. Their structures were established as (17R,20S,22R)-5α,6α,7β,12α-tetrahydroxy- 1-oxowitha-2,24-dienolide (1), (17R,20S,22R,24S,25S)-24,25-epoxy- 5α,6α,7β,12α-tetrahydroxy-1-oxowitha-2-enolide (2), and (17R,20S,22R)- 5α,6α-epoxy-7α-hydr...

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Detalles Bibliográficos
Autores principales: Veleiro, A.S., Cirigliano, A.M., Oberti, J.C., Burton, G.
Formato: JOUR
Materias:
withanolide
article
drug isolation
drug structure
mass spectrometry
molecular model
nonhuman
nuclear magnetic resonance
plant leaf
Datura ferox
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01633864_v62_n7_p1010_Veleiro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Three new withanolides were isolated from leaves of Datura ferox. Their structures were established as (17R,20S,22R)-5α,6α,7β,12α-tetrahydroxy- 1-oxowitha-2,24-dienolide (1), (17R,20S,22R,24S,25S)-24,25-epoxy- 5α,6α,7β,12α-tetrahydroxy-1-oxowitha-2-enolide (2), and (17R,20S,22R)- 5α,6α-epoxy-7α-hydroxy-1,12-dioxowitha-2,24-dienolide (3), using spectroscopic methods (NMR, MS) and molecular modeling.

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