7-Hydroxywithanolides from Datura ferox

Three new withanolides were isolated from leaves of Datura ferox. Their structures were established as (17R,20S,22R)-5α,6α,7β,12α-tetrahydroxy- 1-oxowitha-2,24-dienolide (1), (17R,20S,22R,24S,25S)-24,25-epoxy- 5α,6α,7β,12α-tetrahydroxy-1-oxowitha-2-enolide (2), and (17R,20S,22R)- 5α,6α-epoxy-7α-hydr...

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Detalles Bibliográficos
Autores principales: Veleiro, A.S., Cirigliano, A.M., Oberti, J.C., Burton, G.
Formato: JOUR
Materias:
withanolide
article
drug isolation
drug structure
mass spectrometry
molecular model
nonhuman
nuclear magnetic resonance
plant leaf
Datura ferox
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01633864_v62_n7_p1010_Veleiro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_01633864_v62_n7_p1010_Veleiro
record_format dspace
spelling todo:paper_01633864_v62_n7_p1010_Veleiro2023-10-03T15:02:11Z 7-Hydroxywithanolides from Datura ferox Veleiro, A.S. Cirigliano, A.M. Oberti, J.C. Burton, G. withanolide article drug isolation drug structure mass spectrometry molecular model nonhuman nuclear magnetic resonance plant leaf Datura ferox Three new withanolides were isolated from leaves of Datura ferox. Their structures were established as (17R,20S,22R)-5α,6α,7β,12α-tetrahydroxy- 1-oxowitha-2,24-dienolide (1), (17R,20S,22R,24S,25S)-24,25-epoxy- 5α,6α,7β,12α-tetrahydroxy-1-oxowitha-2-enolide (2), and (17R,20S,22R)- 5α,6α-epoxy-7α-hydroxy-1,12-dioxowitha-2,24-dienolide (3), using spectroscopic methods (NMR, MS) and molecular modeling. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cirigliano, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v62_n7_p1010_Veleiro
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic withanolide
article
drug isolation
drug structure
mass spectrometry
molecular model
nonhuman
nuclear magnetic resonance
plant leaf
Datura ferox
spellingShingle withanolide
article
drug isolation
drug structure
mass spectrometry
molecular model
nonhuman
nuclear magnetic resonance
plant leaf
Datura ferox
Veleiro, A.S.
Cirigliano, A.M.
Oberti, J.C.
Burton, G.
7-Hydroxywithanolides from Datura ferox
topic_facet withanolide
article
drug isolation
drug structure
mass spectrometry
molecular model
nonhuman
nuclear magnetic resonance
plant leaf
Datura ferox
description Three new withanolides were isolated from leaves of Datura ferox. Their structures were established as (17R,20S,22R)-5α,6α,7β,12α-tetrahydroxy- 1-oxowitha-2,24-dienolide (1), (17R,20S,22R,24S,25S)-24,25-epoxy- 5α,6α,7β,12α-tetrahydroxy-1-oxowitha-2-enolide (2), and (17R,20S,22R)- 5α,6α-epoxy-7α-hydroxy-1,12-dioxowitha-2,24-dienolide (3), using spectroscopic methods (NMR, MS) and molecular modeling.
format JOUR
author Veleiro, A.S.
Cirigliano, A.M.
Oberti, J.C.
Burton, G.
author_facet Veleiro, A.S.
Cirigliano, A.M.
Oberti, J.C.
Burton, G.
author_sort Veleiro, A.S.
title 7-Hydroxywithanolides from Datura ferox
title_short 7-Hydroxywithanolides from Datura ferox
title_full 7-Hydroxywithanolides from Datura ferox
title_fullStr 7-Hydroxywithanolides from Datura ferox
title_full_unstemmed 7-Hydroxywithanolides from Datura ferox
title_sort 7-hydroxywithanolides from datura ferox
url http://hdl.handle.net/20.500.12110/paper_01633864_v62_n7_p1010_Veleiro
work_keys_str_mv AT veleiroas 7hydroxywithanolidesfromdaturaferox
AT ciriglianoam 7hydroxywithanolidesfromdaturaferox
AT obertijc 7hydroxywithanolidesfromdaturaferox
AT burtong 7hydroxywithanolidesfromdaturaferox
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