Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis

Celenamide E, a novel tripeptide alkaloid and a possible biosynthetic precursor of the previously reported celenamides A-C, was isolated from the Patagonian sponge Cliona chilensis collected at Rada Tilly, Chubut, Argentina. The structure of celenamide E was elucidated by spectroscopic techniques-UV...

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Detalles Bibliográficos
Autores principales: Palermo, J.A., Brasco, M.F.R., Cabezas, E., Balzaretti, V., Seldes, A.M.
Formato: JOUR
Materias:
alkaloid
celenamide e
unclassified drug
antibacterial activity
article
drug isolation
drug structure
gram positive bacterium
infrared spectroscopy
nonhuman
nuclear magnetic resonance
sponge (porifera)
ultraviolet spectroscopy
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01633864_v61_n4_p488_Palermo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Celenamide E, a novel tripeptide alkaloid and a possible biosynthetic precursor of the previously reported celenamides A-C, was isolated from the Patagonian sponge Cliona chilensis collected at Rada Tilly, Chubut, Argentina. The structure of celenamide E was elucidated by spectroscopic techniques-UV, IR, 1D and 2D NMR (COSY, NOESY, HETCOR, COLOC) experiments - HIRFABMS, and preparation of an hexaacetate derivative. An unusual feature of celenamide E is the presence of a N-terminal dehydroamino acid. Celenamide E shows antibiotic activity against Gram-positive bacteria at 50 μg/disk.

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