Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis

Celenamide E, a novel tripeptide alkaloid and a possible biosynthetic precursor of the previously reported celenamides A-C, was isolated from the Patagonian sponge Cliona chilensis collected at Rada Tilly, Chubut, Argentina. The structure of celenamide E was elucidated by spectroscopic techniques-UV...

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Autores principales: Palermo, J.A., Brasco, M.F.R., Cabezas, E., Balzaretti, V., Seldes, A.M.
Formato: JOUR
Materias:
alkaloid
celenamide e
unclassified drug
antibacterial activity
article
drug isolation
drug structure
gram positive bacterium
infrared spectroscopy
nonhuman
nuclear magnetic resonance
sponge (porifera)
ultraviolet spectroscopy
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01633864_v61_n4_p488_Palermo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_01633864_v61_n4_p488_Palermo
record_format dspace
spelling todo:paper_01633864_v61_n4_p488_Palermo2023-10-03T15:02:09Z Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis Palermo, J.A. Brasco, M.F.R. Cabezas, E. Balzaretti, V. Seldes, A.M. alkaloid celenamide e unclassified drug antibacterial activity article drug isolation drug structure gram positive bacterium infrared spectroscopy nonhuman nuclear magnetic resonance sponge (porifera) ultraviolet spectroscopy Celenamide E, a novel tripeptide alkaloid and a possible biosynthetic precursor of the previously reported celenamides A-C, was isolated from the Patagonian sponge Cliona chilensis collected at Rada Tilly, Chubut, Argentina. The structure of celenamide E was elucidated by spectroscopic techniques-UV, IR, 1D and 2D NMR (COSY, NOESY, HETCOR, COLOC) experiments - HIRFABMS, and preparation of an hexaacetate derivative. An unusual feature of celenamide E is the presence of a N-terminal dehydroamino acid. Celenamide E shows antibiotic activity against Gram-positive bacteria at 50 μg/disk. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v61_n4_p488_Palermo
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic alkaloid
celenamide e
unclassified drug
antibacterial activity
article
drug isolation
drug structure
gram positive bacterium
infrared spectroscopy
nonhuman
nuclear magnetic resonance
sponge (porifera)
ultraviolet spectroscopy
spellingShingle alkaloid
celenamide e
unclassified drug
antibacterial activity
article
drug isolation
drug structure
gram positive bacterium
infrared spectroscopy
nonhuman
nuclear magnetic resonance
sponge (porifera)
ultraviolet spectroscopy
Palermo, J.A.
Brasco, M.F.R.
Cabezas, E.
Balzaretti, V.
Seldes, A.M.
Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis
topic_facet alkaloid
celenamide e
unclassified drug
antibacterial activity
article
drug isolation
drug structure
gram positive bacterium
infrared spectroscopy
nonhuman
nuclear magnetic resonance
sponge (porifera)
ultraviolet spectroscopy
description Celenamide E, a novel tripeptide alkaloid and a possible biosynthetic precursor of the previously reported celenamides A-C, was isolated from the Patagonian sponge Cliona chilensis collected at Rada Tilly, Chubut, Argentina. The structure of celenamide E was elucidated by spectroscopic techniques-UV, IR, 1D and 2D NMR (COSY, NOESY, HETCOR, COLOC) experiments - HIRFABMS, and preparation of an hexaacetate derivative. An unusual feature of celenamide E is the presence of a N-terminal dehydroamino acid. Celenamide E shows antibiotic activity against Gram-positive bacteria at 50 μg/disk.
format JOUR
author Palermo, J.A.
Brasco, M.F.R.
Cabezas, E.
Balzaretti, V.
Seldes, A.M.
author_facet Palermo, J.A.
Brasco, M.F.R.
Cabezas, E.
Balzaretti, V.
Seldes, A.M.
author_sort Palermo, J.A.
title Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis
title_short Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis
title_full Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis
title_fullStr Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis
title_full_unstemmed Celenamide E, a tripeptide alkaloid from the Patagonian sponge Cliona chilensis
title_sort celenamide e, a tripeptide alkaloid from the patagonian sponge cliona chilensis
url http://hdl.handle.net/20.500.12110/paper_01633864_v61_n4_p488_Palermo
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AT brascomfr celenamideeatripeptidealkaloidfromthepatagonianspongeclionachilensis
AT cabezase celenamideeatripeptidealkaloidfromthepatagonianspongeclionachilensis
AT balzarettiv celenamideeatripeptidealkaloidfromthepatagonianspongeclionachilensis
AT seldesam celenamideeatripeptidealkaloidfromthepatagonianspongeclionachilensis
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