New hydroxylated withanolides from Salpichroa origanifolia

From the leaves of Salpichroa origanifolia three new withanolides, (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-15,26-dihydroxy- 17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide G, 1), (20S,22R,24S,25R)-5α,6α:22,26-diepoxy-24,25,26-trihydroxy-17(13→18)-abeo- ergosta-2,13,15,17-tetr...

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Detalles Bibliográficos
Autores principales: Tettamanzi, M.C., Veleiro, A.S., Oberti, J.C., Burton, G.
Formato: JOUR
Materias:
salpichrolide g
salpichrolide h
salpichrolide i
unclassified drug
withanolide
article
carbon nuclear magnetic resonance
chemical structure
hydroxylation
molecular model
nuclear Overhauser effect
plant leaf
proton nuclear magnetic resonance
spectroscopy
stereochemistry
Salpichroa origanifolia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01633864_v61_n3_p338_Tettamanzi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_01633864_v61_n3_p338_Tettamanzi
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spelling todo:paper_01633864_v61_n3_p338_Tettamanzi2023-10-03T15:02:08Z New hydroxylated withanolides from Salpichroa origanifolia Tettamanzi, M.C. Veleiro, A.S. Oberti, J.C. Burton, G. salpichrolide g salpichrolide h salpichrolide i unclassified drug withanolide article carbon nuclear magnetic resonance chemical structure hydroxylation molecular model nuclear Overhauser effect plant leaf proton nuclear magnetic resonance spectroscopy stereochemistry Salpichroa origanifolia From the leaves of Salpichroa origanifolia three new withanolides, (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-15,26-dihydroxy- 17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide G, 1), (20S,22R,24S,25R)-5α,6α:22,26-diepoxy-24,25,26-trihydroxy-17(13→18)-abeo- ergosta-2,13,15,17-tetraen-1-one (salpichrolide H, 2), and (20S,22R,25S)- 5α,6α:22,26-diepoxy-25,26-dihydroxy-17(13→18)-abeo-ergosta-2,13,15,17,23- pentaen-1-one (salpichrolide I, 3), were isolated and characterized by spectroscopic methods and with the aid of molecular modeling. The latter two compounds were obtained as an epimeric mixture at C-26. Fil:Tettamanzi, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01633864_v61_n3_p338_Tettamanzi
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic salpichrolide g
salpichrolide h
salpichrolide i
unclassified drug
withanolide
article
carbon nuclear magnetic resonance
chemical structure
hydroxylation
molecular model
nuclear Overhauser effect
plant leaf
proton nuclear magnetic resonance
spectroscopy
stereochemistry
Salpichroa origanifolia
spellingShingle salpichrolide g
salpichrolide h
salpichrolide i
unclassified drug
withanolide
article
carbon nuclear magnetic resonance
chemical structure
hydroxylation
molecular model
nuclear Overhauser effect
plant leaf
proton nuclear magnetic resonance
spectroscopy
stereochemistry
Salpichroa origanifolia
Tettamanzi, M.C.
Veleiro, A.S.
Oberti, J.C.
Burton, G.
New hydroxylated withanolides from Salpichroa origanifolia
topic_facet salpichrolide g
salpichrolide h
salpichrolide i
unclassified drug
withanolide
article
carbon nuclear magnetic resonance
chemical structure
hydroxylation
molecular model
nuclear Overhauser effect
plant leaf
proton nuclear magnetic resonance
spectroscopy
stereochemistry
Salpichroa origanifolia
description From the leaves of Salpichroa origanifolia three new withanolides, (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-15,26-dihydroxy- 17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide G, 1), (20S,22R,24S,25R)-5α,6α:22,26-diepoxy-24,25,26-trihydroxy-17(13→18)-abeo- ergosta-2,13,15,17-tetraen-1-one (salpichrolide H, 2), and (20S,22R,25S)- 5α,6α:22,26-diepoxy-25,26-dihydroxy-17(13→18)-abeo-ergosta-2,13,15,17,23- pentaen-1-one (salpichrolide I, 3), were isolated and characterized by spectroscopic methods and with the aid of molecular modeling. The latter two compounds were obtained as an epimeric mixture at C-26.
format JOUR
author Tettamanzi, M.C.
Veleiro, A.S.
Oberti, J.C.
Burton, G.
author_facet Tettamanzi, M.C.
Veleiro, A.S.
Oberti, J.C.
Burton, G.
author_sort Tettamanzi, M.C.
title New hydroxylated withanolides from Salpichroa origanifolia
title_short New hydroxylated withanolides from Salpichroa origanifolia
title_full New hydroxylated withanolides from Salpichroa origanifolia
title_fullStr New hydroxylated withanolides from Salpichroa origanifolia
title_full_unstemmed New hydroxylated withanolides from Salpichroa origanifolia
title_sort new hydroxylated withanolides from salpichroa origanifolia
url http://hdl.handle.net/20.500.12110/paper_01633864_v61_n3_p338_Tettamanzi
work_keys_str_mv AT tettamanzimc newhydroxylatedwithanolidesfromsalpichroaoriganifolia
AT veleiroas newhydroxylatedwithanolidesfromsalpichroaoriganifolia
AT obertijc newhydroxylatedwithanolidesfromsalpichroaoriganifolia
AT burtong newhydroxylatedwithanolidesfromsalpichroaoriganifolia
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