GM-CSF enhances a CpG-independent pathway of neutrophil activation triggered by bacterial DNA

We have previously demonstrated that bacterial DNA induces neutrophil activation through a CpG- and TLR9-independent but MyD88-dependent-pathway. In this study we determined that GM-CSF enhances the activation of neutrophils by bacterial DNA. Granulocyte-macrophage colony-stimulating factor increase...

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Detalles Bibliográficos
Autores principales: Bass, J.I.F., Alvarez, M.E., Gabelloni, M.L., Vermeulen, M.E., Amaral, M.M., Geffner, J.R., Trevani, A.S.
Formato: JOUR
Materias:
Bacterial DNA
CpG
GM-CSF
Inflammation
MAPK
Neutrophil
bacterial DNA
CD11b antigen
granulocyte macrophage colony stimulating factor
interleukin 1beta
interleukin 8
mitogen activated protein kinase
mitogen activated protein kinase 1
mitogen activated protein kinase 3
mitogen activated protein kinase p38
myeloid differentiation factor 88
oligodeoxynucleotide derivative
phosphorothioic acid
plasmid DNA
single stranded DNA
toll like receptor 9
animal experiment
article
controlled study
CpG island
cytokine release
DNA methylation
enzyme activation
human
human cell
leukocyte activation
male
mouse
nonhuman
priority journal
upregulation
Animals
Antigens, CD11b
CpG Islands
DNA, Bacterial
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Interleukin-8
Mice
Mice, Inbred C57BL
Myeloid Differentiation Factor 88
Neutrophil Activation
Neutrophils
NF-kappa B
p38 Mitogen-Activated Protein Kinases
Bacteria (microorganisms)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01615890_v46_n1_p37_Bass
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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