Experimental infection of suckling mice with a host range mutant of junin virus
Experimental infection of three mouse strains with a non‐pathogenic mutant of Junin virus named C167 was compared with respect to the parental XJC13 strain. After intracerebral (ic) or intraperitoneal inoculation, XJC13 was highly virulent for 2 day‐old C3H/HeJ, OF1, and BALB/cJ mouse strains, where...
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todo:paper_01466615_v34_n4_p237_Scolaro2023-10-03T15:00:14Z Experimental infection of suckling mice with a host range mutant of junin virus Scolaro, L.A. Mersich, S.E. Damonte, E.B. attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence Experimental infection of three mouse strains with a non‐pathogenic mutant of Junin virus named C167 was compared with respect to the parental XJC13 strain. After intracerebral (ic) or intraperitoneal inoculation, XJC13 was highly virulent for 2 day‐old C3H/HeJ, OF1, and BALB/cJ mouse strains, whereas its derivative C167 was attenuated. Survival of the C167‐infected mouse was associated with a restricted replication at the site of inoculation which would impair spread of virus. Thus, the reduced virulence of C167 for suckling mice is independent of the mouse strain and the route of viral entry. When C167 was preinoculated ic I0 days before the challenge inoculation with XJC13 by the same route, mice were partially protected from lethal infection. Since neutralizing antibodies were first detected at 30 days post‐infection, an interference mechanism is postulated as a mechanism of protection of the mice. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company Fil:Scolaro, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mersich, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01466615_v34_n4_p237_Scolaro |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence |
| spellingShingle |
attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence Scolaro, L.A. Mersich, S.E. Damonte, E.B. Experimental infection of suckling mice with a host range mutant of junin virus |
| topic_facet |
attenuated mutant mouse strain susceptibility protection neutralizing antibody virus vaccine animal experiment animal model antibody detection article immune response immunization junin virus mouse newborn nonhuman priority journal provocation test virus attenuation virus infection virus mutant Animal Antibodies, Viral Arenaviruses, New World Disease Models, Animal Hemorrhagic Fever, American Kinetics Mice Mice, Inbred Strains Mutation Neutralization Tests Plaque Assay Support, Non-U.S. Gov't Vero Cells Virulence |
| description |
Experimental infection of three mouse strains with a non‐pathogenic mutant of Junin virus named C167 was compared with respect to the parental XJC13 strain. After intracerebral (ic) or intraperitoneal inoculation, XJC13 was highly virulent for 2 day‐old C3H/HeJ, OF1, and BALB/cJ mouse strains, whereas its derivative C167 was attenuated. Survival of the C167‐infected mouse was associated with a restricted replication at the site of inoculation which would impair spread of virus. Thus, the reduced virulence of C167 for suckling mice is independent of the mouse strain and the route of viral entry. When C167 was preinoculated ic I0 days before the challenge inoculation with XJC13 by the same route, mice were partially protected from lethal infection. Since neutralizing antibodies were first detected at 30 days post‐infection, an interference mechanism is postulated as a mechanism of protection of the mice. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company |
| format |
JOUR |
| author |
Scolaro, L.A. Mersich, S.E. Damonte, E.B. |
| author_facet |
Scolaro, L.A. Mersich, S.E. Damonte, E.B. |
| author_sort |
Scolaro, L.A. |
| title |
Experimental infection of suckling mice with a host range mutant of junin virus |
| title_short |
Experimental infection of suckling mice with a host range mutant of junin virus |
| title_full |
Experimental infection of suckling mice with a host range mutant of junin virus |
| title_fullStr |
Experimental infection of suckling mice with a host range mutant of junin virus |
| title_full_unstemmed |
Experimental infection of suckling mice with a host range mutant of junin virus |
| title_sort |
experimental infection of suckling mice with a host range mutant of junin virus |
| url |
http://hdl.handle.net/20.500.12110/paper_01466615_v34_n4_p237_Scolaro |
| work_keys_str_mv |
AT scolarola experimentalinfectionofsucklingmicewithahostrangemutantofjuninvirus AT mersichse experimentalinfectionofsucklingmicewithahostrangemutantofjuninvirus AT damonteeb experimentalinfectionofsucklingmicewithahostrangemutantofjuninvirus |
| _version_ |
1807324236745801728 |