Antigenic relationships between attenuated and pathogenic strains of junin virus

Antigenic relationships between attenuated and pathogenic strains of Junin virus (JV) were investigated. Five strains of either human or rodent origin were tested by cross‐neutralization assay with hyperimmune antisera, raised in rabbits, against each strain. Polyclonal antisera could be used to dis...

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Detalles Bibliográficos
Autores principales: Candurra, N.A., Damonte, E.B., Coto, C.E.
Formato: JOUR
Materias:
antigenic relationships
Argentinian hemorrhagic fever
differentiation of strains
Junin virus
neutralization
serology
virus antigen
classification
hemorrhagic fever
junin virus
nonhuman
priority journal
virus attenuation
virus neutralization
virus strain
virus virulence
Animal
Arenaviridae
Arenaviruses, New World
Epitopes
Guinea Pigs
Immune Sera
Mice
Neutralization Tests
Support, Non-U.S. Gov't
Virulence
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01466615_v27_n2_p145_Candurra
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Antigenic relationships between attenuated and pathogenic strains of Junin virus (JV) were investigated. Five strains of either human or rodent origin were tested by cross‐neutralization assay with hyperimmune antisera, raised in rabbits, against each strain. Polyclonal antisera could be used to distinguish among these JV strains, as the titer values differed significantly with ratios of homologous to heterologous titers, which ranged from 1.3 to 22.3. This demonstrates, independent of their virulence, a heterogeneity among the JV strains tested. The relatedness among JV strains was expressed quantitatively through a dendrogram based on taxonomic distance coefficients. The field strains of JV were grouped into two clusters, according to their geographic origin. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company

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