Antigenic relationships between attenuated and pathogenic strains of junin virus
Antigenic relationships between attenuated and pathogenic strains of Junin virus (JV) were investigated. Five strains of either human or rodent origin were tested by cross‐neutralization assay with hyperimmune antisera, raised in rabbits, against each strain. Polyclonal antisera could be used to dis...
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todo:paper_01466615_v27_n2_p145_Candurra2023-10-03T15:00:14Z Antigenic relationships between attenuated and pathogenic strains of junin virus Candurra, N.A. Damonte, E.B. Coto, C.E. antigenic relationships Argentinian hemorrhagic fever differentiation of strains Junin virus neutralization serology virus antigen classification hemorrhagic fever junin virus nonhuman priority journal virus attenuation virus neutralization virus strain virus virulence Animal Arenaviridae Arenaviruses, New World Epitopes Guinea Pigs Immune Sera Mice Neutralization Tests Support, Non-U.S. Gov't Virulence Antigenic relationships between attenuated and pathogenic strains of Junin virus (JV) were investigated. Five strains of either human or rodent origin were tested by cross‐neutralization assay with hyperimmune antisera, raised in rabbits, against each strain. Polyclonal antisera could be used to distinguish among these JV strains, as the titer values differed significantly with ratios of homologous to heterologous titers, which ranged from 1.3 to 22.3. This demonstrates, independent of their virulence, a heterogeneity among the JV strains tested. The relatedness among JV strains was expressed quantitatively through a dendrogram based on taxonomic distance coefficients. The field strains of JV were grouped into two clusters, according to their geographic origin. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company Fil:Candurra, N.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01466615_v27_n2_p145_Candurra |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
antigenic relationships Argentinian hemorrhagic fever differentiation of strains Junin virus neutralization serology virus antigen classification hemorrhagic fever junin virus nonhuman priority journal virus attenuation virus neutralization virus strain virus virulence Animal Arenaviridae Arenaviruses, New World Epitopes Guinea Pigs Immune Sera Mice Neutralization Tests Support, Non-U.S. Gov't Virulence |
| spellingShingle |
antigenic relationships Argentinian hemorrhagic fever differentiation of strains Junin virus neutralization serology virus antigen classification hemorrhagic fever junin virus nonhuman priority journal virus attenuation virus neutralization virus strain virus virulence Animal Arenaviridae Arenaviruses, New World Epitopes Guinea Pigs Immune Sera Mice Neutralization Tests Support, Non-U.S. Gov't Virulence Candurra, N.A. Damonte, E.B. Coto, C.E. Antigenic relationships between attenuated and pathogenic strains of junin virus |
| topic_facet |
antigenic relationships Argentinian hemorrhagic fever differentiation of strains Junin virus neutralization serology virus antigen classification hemorrhagic fever junin virus nonhuman priority journal virus attenuation virus neutralization virus strain virus virulence Animal Arenaviridae Arenaviruses, New World Epitopes Guinea Pigs Immune Sera Mice Neutralization Tests Support, Non-U.S. Gov't Virulence |
| description |
Antigenic relationships between attenuated and pathogenic strains of Junin virus (JV) were investigated. Five strains of either human or rodent origin were tested by cross‐neutralization assay with hyperimmune antisera, raised in rabbits, against each strain. Polyclonal antisera could be used to distinguish among these JV strains, as the titer values differed significantly with ratios of homologous to heterologous titers, which ranged from 1.3 to 22.3. This demonstrates, independent of their virulence, a heterogeneity among the JV strains tested. The relatedness among JV strains was expressed quantitatively through a dendrogram based on taxonomic distance coefficients. The field strains of JV were grouped into two clusters, according to their geographic origin. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company |
| format |
JOUR |
| author |
Candurra, N.A. Damonte, E.B. Coto, C.E. |
| author_facet |
Candurra, N.A. Damonte, E.B. Coto, C.E. |
| author_sort |
Candurra, N.A. |
| title |
Antigenic relationships between attenuated and pathogenic strains of junin virus |
| title_short |
Antigenic relationships between attenuated and pathogenic strains of junin virus |
| title_full |
Antigenic relationships between attenuated and pathogenic strains of junin virus |
| title_fullStr |
Antigenic relationships between attenuated and pathogenic strains of junin virus |
| title_full_unstemmed |
Antigenic relationships between attenuated and pathogenic strains of junin virus |
| title_sort |
antigenic relationships between attenuated and pathogenic strains of junin virus |
| url |
http://hdl.handle.net/20.500.12110/paper_01466615_v27_n2_p145_Candurra |
| work_keys_str_mv |
AT candurrana antigenicrelationshipsbetweenattenuatedandpathogenicstrainsofjuninvirus AT damonteeb antigenicrelationshipsbetweenattenuatedandpathogenicstrainsofjuninvirus AT cotoce antigenicrelationshipsbetweenattenuatedandpathogenicstrainsofjuninvirus |
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1807321856009568256 |