Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice
In a previous paper we reported the occurrence of a high incidence of lymphomas in N-methyl-N-nitrosourea (MNU)-treated mice, in the course of an experiment of combined chemical-hormonal carcinogenesis in mammary gland, in which we used medroxyprogesterone acetate (MPA) and MNU in different treatmen...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01452126_v25_n2_p165_Pazos |
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todo:paper_01452126_v25_n2_p165_Pazos2023-10-03T14:59:52Z Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice Pazos, P. Lanari, C. Molinolo, A.A. Lymphoma Medroxyprogesterone acetate Mice N-methyl-N-nitrosourea Progestins medroxyprogesterone acetate methylnitrosourea animal experiment animal model animal tissue article controlled study drug effect female immunocytochemistry incidence lymphoma mouse nonhuman priority journal protection Animals Female Immunohistochemistry Incidence Lymphoma Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C In a previous paper we reported the occurrence of a high incidence of lymphomas in N-methyl-N-nitrosourea (MNU)-treated mice, in the course of an experiment of combined chemical-hormonal carcinogenesis in mammary gland, in which we used medroxyprogesterone acetate (MPA) and MNU in different treatment protocols. In this report we have analyzed the action of MPA in the leukemogenic effects of MNU, by specifically selecting for the analysis experimental groups in which only few mammary carcinomas had developed. A high incidence of lymphomas (65%, median latency: 176 days) was registered in MNU-treated mice, and the administration of MPA was associated with a significant reduction in the incidence of lymphomas (P<0.001) in all protocols. Copyright © 2001 Elsevier Science Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01452126_v25_n2_p165_Pazos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Lymphoma Medroxyprogesterone acetate Mice N-methyl-N-nitrosourea Progestins medroxyprogesterone acetate methylnitrosourea animal experiment animal model animal tissue article controlled study drug effect female immunocytochemistry incidence lymphoma mouse nonhuman priority journal protection Animals Female Immunohistochemistry Incidence Lymphoma Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C |
| spellingShingle |
Lymphoma Medroxyprogesterone acetate Mice N-methyl-N-nitrosourea Progestins medroxyprogesterone acetate methylnitrosourea animal experiment animal model animal tissue article controlled study drug effect female immunocytochemistry incidence lymphoma mouse nonhuman priority journal protection Animals Female Immunohistochemistry Incidence Lymphoma Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C Pazos, P. Lanari, C. Molinolo, A.A. Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice |
| topic_facet |
Lymphoma Medroxyprogesterone acetate Mice N-methyl-N-nitrosourea Progestins medroxyprogesterone acetate methylnitrosourea animal experiment animal model animal tissue article controlled study drug effect female immunocytochemistry incidence lymphoma mouse nonhuman priority journal protection Animals Female Immunohistochemistry Incidence Lymphoma Medroxyprogesterone 17-Acetate Methylnitrosourea Mice Mice, Inbred BALB C |
| description |
In a previous paper we reported the occurrence of a high incidence of lymphomas in N-methyl-N-nitrosourea (MNU)-treated mice, in the course of an experiment of combined chemical-hormonal carcinogenesis in mammary gland, in which we used medroxyprogesterone acetate (MPA) and MNU in different treatment protocols. In this report we have analyzed the action of MPA in the leukemogenic effects of MNU, by specifically selecting for the analysis experimental groups in which only few mammary carcinomas had developed. A high incidence of lymphomas (65%, median latency: 176 days) was registered in MNU-treated mice, and the administration of MPA was associated with a significant reduction in the incidence of lymphomas (P<0.001) in all protocols. Copyright © 2001 Elsevier Science Ltd. |
| format |
JOUR |
| author |
Pazos, P. Lanari, C. Molinolo, A.A. |
| author_facet |
Pazos, P. Lanari, C. Molinolo, A.A. |
| author_sort |
Pazos, P. |
| title |
Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice |
| title_short |
Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice |
| title_full |
Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice |
| title_fullStr |
Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice |
| title_full_unstemmed |
Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice |
| title_sort |
protective role of medroxyprogesterone acetate on n-methyl-n-nitrosourea-induced lymphomas in balb/c female mice |
| url |
http://hdl.handle.net/20.500.12110/paper_01452126_v25_n2_p165_Pazos |
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