Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus

Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6...

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Autores principales:	De S.f-Tischer, P.C., Talarico, L.B., Noseda, M.D., Pita B. Guimarães, S.M., Damonte, E.B., Duarte, M.E.R.
Formato:	JOUR
Materias:	Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Chemical structures Viruses algae Herpes Human herpesvirus 2 Simplexvirus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01448617_v63_n4_p459_DeSfTischer
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_01448617_v63_n4_p459_DeSfTischer2023-10-03T14:59:45Z Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus De S.f-Tischer, P.C. Talarico, L.B. Noseda, M.D. Pita B. Guimarães, S.M. Damonte, E.B. Duarte, M.E.R. Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6-956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections. © 2005 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01448617_v63_n4_p459_DeSfTischer
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae
spellingShingle	Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae De S.f-Tischer, P.C. Talarico, L.B. Noseda, M.D. Pita B. Guimarães, S.M. Damonte, E.B. Duarte, M.E.R. Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
topic_facet	Antiviral activity Chemical structure Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Molecular structure Polysaccharides Potassium compounds Spectroscopy Antiviral activity Chemical structures Dengue virus Herpes simplex virus Iota/kappa-carrageenan Meristiella gelidium Solieriaceae Viruses algae Dengue virus Herpes Human herpesvirus 2 Meristiella gelidium Simplexvirus Solieriaceae
description	Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6-956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections. © 2005 Elsevier Ltd. All rights reserved.
format	JOUR
author	De S.f-Tischer, P.C. Talarico, L.B. Noseda, M.D. Pita B. Guimarães, S.M. Damonte, E.B. Duarte, M.E.R.
author_facet	De S.f-Tischer, P.C. Talarico, L.B. Noseda, M.D. Pita B. Guimarães, S.M. Damonte, E.B. Duarte, M.E.R.
author_sort	De S.f-Tischer, P.C.
title	Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_short	Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_full	Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_fullStr	Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_full_unstemmed	Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_sort	chemical structure and antiviral activity of carrageenans from meristiella gelidium against herpes simplex and dengue virus
url	http://hdl.handle.net/20.500.12110/paper_01448617_v63_n4_p459_DeSfTischer
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Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus

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