A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values fo...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01434160_v35_n5_p403_Fraiman |
| Aporte de: |
| id |
todo:paper_01434160_v35_n5_p403_Fraiman |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_01434160_v35_n5_p403_Fraiman2023-10-03T14:59:20Z A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis Fraiman, D. Dawson, S.P. InsP3-receptor Luminal Ca2+ Stochastic model calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel cell receptor article binding site calcium binding channel gating controlled study cytosol experimental model medical literature observation priority journal probability quantitative analysis simulation stochastic model calcium signaling chemical model chemistry metabolism protein binding Binding Sites Calcium Calcium Channels Calcium Signaling Models, Chemical Protein Binding Receptors, Cytoplasmic and Nuclear We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that agree with the observations. The model includes an explicit dependence of channel gating with luminal calcium. This not only explains several observations reported in the literature, but also provides a possible explanation of why the open probabilities and shapes of the bell-shaped curves reported in [Nature 351 (1991) 751] and in [Proc. Natl. Acad. Sci. U.S.A. 269 (1998) 7238] are so different. © 2003 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01434160_v35_n5_p403_Fraiman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
InsP3-receptor Luminal Ca2+ Stochastic model calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel cell receptor article binding site calcium binding channel gating controlled study cytosol experimental model medical literature observation priority journal probability quantitative analysis simulation stochastic model calcium signaling chemical model chemistry metabolism protein binding Binding Sites Calcium Calcium Channels Calcium Signaling Models, Chemical Protein Binding Receptors, Cytoplasmic and Nuclear |
| spellingShingle |
InsP3-receptor Luminal Ca2+ Stochastic model calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel cell receptor article binding site calcium binding channel gating controlled study cytosol experimental model medical literature observation priority journal probability quantitative analysis simulation stochastic model calcium signaling chemical model chemistry metabolism protein binding Binding Sites Calcium Calcium Channels Calcium Signaling Models, Chemical Protein Binding Receptors, Cytoplasmic and Nuclear Fraiman, D. Dawson, S.P. A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis |
| topic_facet |
InsP3-receptor Luminal Ca2+ Stochastic model calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel cell receptor article binding site calcium binding channel gating controlled study cytosol experimental model medical literature observation priority journal probability quantitative analysis simulation stochastic model calcium signaling chemical model chemistry metabolism protein binding Binding Sites Calcium Calcium Channels Calcium Signaling Models, Chemical Protein Binding Receptors, Cytoplasmic and Nuclear |
| description |
We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that agree with the observations. The model includes an explicit dependence of channel gating with luminal calcium. This not only explains several observations reported in the literature, but also provides a possible explanation of why the open probabilities and shapes of the bell-shaped curves reported in [Nature 351 (1991) 751] and in [Proc. Natl. Acad. Sci. U.S.A. 269 (1998) 7238] are so different. © 2003 Elsevier Ltd. All rights reserved. |
| format |
JOUR |
| author |
Fraiman, D. Dawson, S.P. |
| author_facet |
Fraiman, D. Dawson, S.P. |
| author_sort |
Fraiman, D. |
| title |
A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis |
| title_short |
A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis |
| title_full |
A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis |
| title_fullStr |
A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis |
| title_full_unstemmed |
A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis |
| title_sort |
model of the ip3 receptor with a luminal calcium binding site: stochastic simulations and analysis |
| url |
http://hdl.handle.net/20.500.12110/paper_01434160_v35_n5_p403_Fraiman |
| work_keys_str_mv |
AT fraimand amodeloftheip3receptorwithaluminalcalciumbindingsitestochasticsimulationsandanalysis AT dawsonsp amodeloftheip3receptorwithaluminalcalciumbindingsitestochasticsimulationsandanalysis AT fraimand modeloftheip3receptorwithaluminalcalciumbindingsitestochasticsimulationsandanalysis AT dawsonsp modeloftheip3receptorwithaluminalcalciumbindingsitestochasticsimulationsandanalysis |
| _version_ |
1807319714016264192 |