Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol

Chemoenzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol was achieved by esterification of 1-O-hexadecyl-sn-glycerol, with palmitic acid in the presence of N,N-dicyclohexylcarbodiimide, and then subjected to alcoholysis catalysed by an immobilized 1,3-specific lipase. The highest yield (9...

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Autores principales: Salto, M.L., Bertello, L.E., De Lederkremer, R.M.
Formato: JOUR
Materias:
4 methyl 2 pentanone
dicyclohexylcarbodiimide
glycerol derivative
palmitic acid
solvent
triacylglycerol lipase
article
enzyme immobilization
esterification
synthesis
time
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01415492_v19_n9_p853_Salto
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_01415492_v19_n9_p853_Salto
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spelling todo:paper_01415492_v19_n9_p853_Salto2023-10-03T14:58:37Z Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol Salto, M.L. Bertello, L.E. De Lederkremer, R.M. 4 methyl 2 pentanone dicyclohexylcarbodiimide glycerol derivative palmitic acid solvent triacylglycerol lipase article enzyme immobilization esterification synthesis time Chemoenzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol was achieved by esterification of 1-O-hexadecyl-sn-glycerol, with palmitic acid in the presence of N,N-dicyclohexylcarbodiimide, and then subjected to alcoholysis catalysed by an immobilized 1,3-specific lipase. The highest yield (90% from 0.3 mM) was obtained in 3 h, using methyl isobutyl ketone as solvent with water activity 0.2. Fil:Salto, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bertello, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De Lederkremer, R.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01415492_v19_n9_p853_Salto
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 4 methyl 2 pentanone
dicyclohexylcarbodiimide
glycerol derivative
palmitic acid
solvent
triacylglycerol lipase
article
enzyme immobilization
esterification
synthesis
time
spellingShingle 4 methyl 2 pentanone
dicyclohexylcarbodiimide
glycerol derivative
palmitic acid
solvent
triacylglycerol lipase
article
enzyme immobilization
esterification
synthesis
time
Salto, M.L.
Bertello, L.E.
De Lederkremer, R.M.
Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol
topic_facet 4 methyl 2 pentanone
dicyclohexylcarbodiimide
glycerol derivative
palmitic acid
solvent
triacylglycerol lipase
article
enzyme immobilization
esterification
synthesis
time
description Chemoenzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol was achieved by esterification of 1-O-hexadecyl-sn-glycerol, with palmitic acid in the presence of N,N-dicyclohexylcarbodiimide, and then subjected to alcoholysis catalysed by an immobilized 1,3-specific lipase. The highest yield (90% from 0.3 mM) was obtained in 3 h, using methyl isobutyl ketone as solvent with water activity 0.2.
format JOUR
author Salto, M.L.
Bertello, L.E.
De Lederkremer, R.M.
author_facet Salto, M.L.
Bertello, L.E.
De Lederkremer, R.M.
author_sort Salto, M.L.
title Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol
title_short Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol
title_full Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol
title_fullStr Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol
title_full_unstemmed Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol
title_sort chemo-enzymatic synthesis of 1-o-hexadecyl-2-o-palmitoyl-sn-glycerol
url http://hdl.handle.net/20.500.12110/paper_01415492_v19_n9_p853_Salto
work_keys_str_mv AT saltoml chemoenzymaticsynthesisof1ohexadecyl2opalmitoylsnglycerol
AT bertellole chemoenzymaticsynthesisof1ohexadecyl2opalmitoylsnglycerol
AT delederkremerrm chemoenzymaticsynthesisof1ohexadecyl2opalmitoylsnglycerol
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