Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus
On sudden presentation of a passing shadow a visual danger stimulus), the crab Chasmagnathus granulatus responds with a running reaction that we term an escape response (ER). A single administration of 5-HT in a dose range between 0.005 and 0.1 μg/g enhances the ER at 30 min, and a dose of 10-15 μg/...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00913057_v53_n2_p441_Aggio |
| Aporte de: |
| id |
todo:paper_00913057_v53_n2_p441_Aggio |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_00913057_v53_n2_p441_Aggio2023-10-03T14:54:56Z Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus Aggio, J. Rakitín, A. Maldonado, H. crab cyproheptadine sensitization serotonin cyproheptadine serotonin serotonin antagonist serotonin receptor animal experiment article controlled study crab drug antagonism escape behavior male nonhuman priority journal sensitization Animalia Aplysia Chasmagnathus Chasmagnathus granulata Decapoda (Crustacea) On sudden presentation of a passing shadow a visual danger stimulus), the crab Chasmagnathus granulatus responds with a running reaction that we term an escape response (ER). A single administration of 5-HT in a dose range between 0.005 and 0.1 μg/g enhances the ER at 30 min, and a dose of 10-15 μg/g has a similar effect for at least 24 h. The classical 5-HT antagonist cyproheptadine (CYP) given within a dose range 0.01-2.0 μg/g has no effect on ER at 30 min, but 0.5 μg/g blocks the 5-HT-induced short-term sensitization. An enhancing effect of CYP on the ER is shown at 24 h with 1.0-2.0 μg/g doses. An explanation of this results in terms of a model similar to that proposed for Aplysia, that is two sensitizing processes linked in parallel and mediated by two different types of 5-HT receptors is discussed. Results indicate that the sensitizing effect of 5-HT is confined to high responders, thus suggesting that crabs of a same population have different degrees of sensitivity to the drug according to their different degrees of reactivity to the visual danger stimulus. Fil:Aggio, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00913057_v53_n2_p441_Aggio |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
crab cyproheptadine sensitization serotonin cyproheptadine serotonin serotonin antagonist serotonin receptor animal experiment article controlled study crab drug antagonism escape behavior male nonhuman priority journal sensitization Animalia Aplysia Chasmagnathus Chasmagnathus granulata Decapoda (Crustacea) |
| spellingShingle |
crab cyproheptadine sensitization serotonin cyproheptadine serotonin serotonin antagonist serotonin receptor animal experiment article controlled study crab drug antagonism escape behavior male nonhuman priority journal sensitization Animalia Aplysia Chasmagnathus Chasmagnathus granulata Decapoda (Crustacea) Aggio, J. Rakitín, A. Maldonado, H. Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus |
| topic_facet |
crab cyproheptadine sensitization serotonin cyproheptadine serotonin serotonin antagonist serotonin receptor animal experiment article controlled study crab drug antagonism escape behavior male nonhuman priority journal sensitization Animalia Aplysia Chasmagnathus Chasmagnathus granulata Decapoda (Crustacea) |
| description |
On sudden presentation of a passing shadow a visual danger stimulus), the crab Chasmagnathus granulatus responds with a running reaction that we term an escape response (ER). A single administration of 5-HT in a dose range between 0.005 and 0.1 μg/g enhances the ER at 30 min, and a dose of 10-15 μg/g has a similar effect for at least 24 h. The classical 5-HT antagonist cyproheptadine (CYP) given within a dose range 0.01-2.0 μg/g has no effect on ER at 30 min, but 0.5 μg/g blocks the 5-HT-induced short-term sensitization. An enhancing effect of CYP on the ER is shown at 24 h with 1.0-2.0 μg/g doses. An explanation of this results in terms of a model similar to that proposed for Aplysia, that is two sensitizing processes linked in parallel and mediated by two different types of 5-HT receptors is discussed. Results indicate that the sensitizing effect of 5-HT is confined to high responders, thus suggesting that crabs of a same population have different degrees of sensitivity to the drug according to their different degrees of reactivity to the visual danger stimulus. |
| format |
JOUR |
| author |
Aggio, J. Rakitín, A. Maldonado, H. |
| author_facet |
Aggio, J. Rakitín, A. Maldonado, H. |
| author_sort |
Aggio, J. |
| title |
Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus |
| title_short |
Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus |
| title_full |
Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus |
| title_fullStr |
Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus |
| title_full_unstemmed |
Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus |
| title_sort |
serotonin-induced short- and long-term sensitization in the crab chasmagnathus |
| url |
http://hdl.handle.net/20.500.12110/paper_00913057_v53_n2_p441_Aggio |
| work_keys_str_mv |
AT aggioj serotonininducedshortandlongtermsensitizationinthecrabchasmagnathus AT rakitina serotonininducedshortandlongtermsensitizationinthecrabchasmagnathus AT maldonadoh serotonininducedshortandlongtermsensitizationinthecrabchasmagnathus |
| _version_ |
1807317626034061312 |