Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats

The output of prostaglandin (PG) F and PGE-like material into the solution bathing uterine horns isolated from adult ovariectomized and immature rats under the influence of progesterone, was studied. The injection of progesterone (0.5; 1.0; 2.0 or 4.0 mg) hours prior to sacrifice enhanced significan...

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Autores principales: Franchi, A.M., Gonzalez, E.T., Gimeno, M.F., Gimeno, A.L.
Formato: JOUR
Materias:
indometacin
progesterone
prostaglandin f2 alpha
puromycin
age
animal experiment
drug efficacy
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Aging
Animal
Castration
Dinoprost
Dose-Response Relationship, Drug
Female
Kinetics
Progesterone
Prostaglandins F
Puromycin
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00906980_v24_n6_p775_Franchi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00906980_v24_n6_p775_Franchi
record_format dspace
spelling todo:paper_00906980_v24_n6_p775_Franchi2023-10-03T14:54:48Z Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats Franchi, A.M. Gonzalez, E.T. Gimeno, M.F. Gimeno, A.L. indometacin progesterone prostaglandin f2 alpha puromycin age animal experiment drug efficacy endocrine system female genital system nonhuman ovariectomy rat uterus Aging Animal Castration Dinoprost Dose-Response Relationship, Drug Female Kinetics Progesterone Prostaglandins F Puromycin Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uterus The output of prostaglandin (PG) F and PGE-like material into the solution bathing uterine horns isolated from adult ovariectomized and immature rats under the influence of progesterone, was studied. The injection of progesterone (0.5; 1.0; 2.0 or 4.0 mg) hours prior to sacrifice enhanced significantly the release of PGF-like substance without modifying that of PGE. The augmentation of PGF was detected as early as one hour after injecting 4.0 mg of progesterone and remained elevated at 2,4,6, 12 and 24 hours, following the treatment. Puromycin (50 mg/Kg), injected 6 hours before killing, failed to alter the release of PGF-like substance but clearly blocked the stimulating effect of the hormone. In addition, progesterone also enhanced significantly the release of PGF-like material by horns isolated from immature animals. The results suggest that progesterone receptors do not appear to be important for the described effect of the hormone because the preparations employed in the present study have a very small content of these receptors. Alternatively, it can be hypothesized that only a reduced number of progesterone receptors are sufficient for the action of the hormone augmenting the output of PGF-like material from the uterus. © 1983. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v24_n6_p775_Franchi
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic indometacin
progesterone
prostaglandin f2 alpha
puromycin
age
animal experiment
drug efficacy
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Aging
Animal
Castration
Dinoprost
Dose-Response Relationship, Drug
Female
Kinetics
Progesterone
Prostaglandins F
Puromycin
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
spellingShingle indometacin
progesterone
prostaglandin f2 alpha
puromycin
age
animal experiment
drug efficacy
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Aging
Animal
Castration
Dinoprost
Dose-Response Relationship, Drug
Female
Kinetics
Progesterone
Prostaglandins F
Puromycin
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
Franchi, A.M.
Gonzalez, E.T.
Gimeno, M.F.
Gimeno, A.L.
Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats
topic_facet indometacin
progesterone
prostaglandin f2 alpha
puromycin
age
animal experiment
drug efficacy
endocrine system
female genital system
nonhuman
ovariectomy
rat
uterus
Aging
Animal
Castration
Dinoprost
Dose-Response Relationship, Drug
Female
Kinetics
Progesterone
Prostaglandins F
Puromycin
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uterus
description The output of prostaglandin (PG) F and PGE-like material into the solution bathing uterine horns isolated from adult ovariectomized and immature rats under the influence of progesterone, was studied. The injection of progesterone (0.5; 1.0; 2.0 or 4.0 mg) hours prior to sacrifice enhanced significantly the release of PGF-like substance without modifying that of PGE. The augmentation of PGF was detected as early as one hour after injecting 4.0 mg of progesterone and remained elevated at 2,4,6, 12 and 24 hours, following the treatment. Puromycin (50 mg/Kg), injected 6 hours before killing, failed to alter the release of PGF-like substance but clearly blocked the stimulating effect of the hormone. In addition, progesterone also enhanced significantly the release of PGF-like material by horns isolated from immature animals. The results suggest that progesterone receptors do not appear to be important for the described effect of the hormone because the preparations employed in the present study have a very small content of these receptors. Alternatively, it can be hypothesized that only a reduced number of progesterone receptors are sufficient for the action of the hormone augmenting the output of PGF-like material from the uterus. © 1983.
format JOUR
author Franchi, A.M.
Gonzalez, E.T.
Gimeno, M.F.
Gimeno, A.L.
author_facet Franchi, A.M.
Gonzalez, E.T.
Gimeno, M.F.
Gimeno, A.L.
author_sort Franchi, A.M.
title Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats
title_short Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats
title_full Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats
title_fullStr Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats
title_full_unstemmed Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats
title_sort progesterone enhances the output of prostaglandin f2-alpha by uterine horns isolated from adult ovariectomized and immature rats
url http://hdl.handle.net/20.500.12110/paper_00906980_v24_n6_p775_Franchi
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AT gonzalezet progesteroneenhancestheoutputofprostaglandinf2alphabyuterinehornsisolatedfromadultovariectomizedandimmaturerats
AT gimenomf progesteroneenhancestheoutputofprostaglandinf2alphabyuterinehornsisolatedfromadultovariectomizedandimmaturerats
AT gimenoal progesteroneenhancestheoutputofprostaglandinf2alphabyuterinehornsisolatedfromadultovariectomizedandimmaturerats
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