Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats
The effect of corticosterone (CC, 0.4 and 1 μg/ml) and of hydrocortisone (HC, 20 and 40 μg/ml) on the spontaneous motility and on prostaglandin (PG) generation in the uterus from ovariectomized rats, was studied. Both concentrations of CC depressed significantly the frequency of contractions but the...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00906980_v23_n1_p113_Bonacossa |
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todo:paper_00906980_v23_n1_p113_Bonacossa2023-10-03T14:54:47Z Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats Bonacossa, A. Sterin-Speziale, N. Gimeno, M.F. Gimeno, A.L. arachidonic acid corticosterone gamma linolenic acid hydrocortisone linoleic acid prostaglandin animal experiment drug comparison female genital system in vitro study ovariectomy rat uterus uterus contractility Animal Arachidonic Acid Arachidonic Acids Castration Corticosterone Dose-Response Relationship, Drug Female gamma-Linolenic Acid Hydrocortisone In Vitro Linoleic Acid Linoleic Acids Linolenic Acids Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uterine Contraction Uterus The effect of corticosterone (CC, 0.4 and 1 μg/ml) and of hydrocortisone (HC, 20 and 40 μg/ml) on the spontaneous motility and on prostaglandin (PG) generation in the uterus from ovariectomized rats, was studied. Both concentrations of CC depressed significantly the frequency of contractions but the isometric developed tension was affected only by the higher dose. HC concentrations whereas the contractile frequency was only depressed by the higher one. The CC-inhibited motility was accompanied by a reduction in the amount of PGs released from the uterus into the bath solution. In addition, the influence of arachidonic acid (AA), linoleic acid (LA) and gamma-linolenic acid (γ-LA) - 1 or 2 μg/ml - on the depression evoked by CC, were also explored. The fatty acids had no effect on the spontaneous uterine motility except in the case of γ-LA at 1 μg/ml. γ-LA completely blocked the CC-evoked reduction of bothe tension and frequency; AA (1μg/ml) elicited a reversion only on frequency whereas LA had no effect at all. This reversion by a fatty acid PG-precursor might indicate that CC is able to diminish substrate availability for PG synthesis in the rat uterus. © 1982. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v23_n1_p113_Bonacossa |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
arachidonic acid corticosterone gamma linolenic acid hydrocortisone linoleic acid prostaglandin animal experiment drug comparison female genital system in vitro study ovariectomy rat uterus uterus contractility Animal Arachidonic Acid Arachidonic Acids Castration Corticosterone Dose-Response Relationship, Drug Female gamma-Linolenic Acid Hydrocortisone In Vitro Linoleic Acid Linoleic Acids Linolenic Acids Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uterine Contraction Uterus |
| spellingShingle |
arachidonic acid corticosterone gamma linolenic acid hydrocortisone linoleic acid prostaglandin animal experiment drug comparison female genital system in vitro study ovariectomy rat uterus uterus contractility Animal Arachidonic Acid Arachidonic Acids Castration Corticosterone Dose-Response Relationship, Drug Female gamma-Linolenic Acid Hydrocortisone In Vitro Linoleic Acid Linoleic Acids Linolenic Acids Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uterine Contraction Uterus Bonacossa, A. Sterin-Speziale, N. Gimeno, M.F. Gimeno, A.L. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats |
| topic_facet |
arachidonic acid corticosterone gamma linolenic acid hydrocortisone linoleic acid prostaglandin animal experiment drug comparison female genital system in vitro study ovariectomy rat uterus uterus contractility Animal Arachidonic Acid Arachidonic Acids Castration Corticosterone Dose-Response Relationship, Drug Female gamma-Linolenic Acid Hydrocortisone In Vitro Linoleic Acid Linoleic Acids Linolenic Acids Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uterine Contraction Uterus |
| description |
The effect of corticosterone (CC, 0.4 and 1 μg/ml) and of hydrocortisone (HC, 20 and 40 μg/ml) on the spontaneous motility and on prostaglandin (PG) generation in the uterus from ovariectomized rats, was studied. Both concentrations of CC depressed significantly the frequency of contractions but the isometric developed tension was affected only by the higher dose. HC concentrations whereas the contractile frequency was only depressed by the higher one. The CC-inhibited motility was accompanied by a reduction in the amount of PGs released from the uterus into the bath solution. In addition, the influence of arachidonic acid (AA), linoleic acid (LA) and gamma-linolenic acid (γ-LA) - 1 or 2 μg/ml - on the depression evoked by CC, were also explored. The fatty acids had no effect on the spontaneous uterine motility except in the case of γ-LA at 1 μg/ml. γ-LA completely blocked the CC-evoked reduction of bothe tension and frequency; AA (1μg/ml) elicited a reversion only on frequency whereas LA had no effect at all. This reversion by a fatty acid PG-precursor might indicate that CC is able to diminish substrate availability for PG synthesis in the rat uterus. © 1982. |
| format |
JOUR |
| author |
Bonacossa, A. Sterin-Speziale, N. Gimeno, M.F. Gimeno, A.L. |
| author_facet |
Bonacossa, A. Sterin-Speziale, N. Gimeno, M.F. Gimeno, A.L. |
| author_sort |
Bonacossa, A. |
| title |
Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats |
| title_short |
Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats |
| title_full |
Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats |
| title_fullStr |
Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats |
| title_full_unstemmed |
Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats |
| title_sort |
effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats |
| url |
http://hdl.handle.net/20.500.12110/paper_00906980_v23_n1_p113_Bonacossa |
| work_keys_str_mv |
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| _version_ |
1782026016838909952 |