Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis

Isolated coronary arteries from diabetic dogs presented different contractile response to U-46619 to prostacyclin (PGI2) and to arachidonic acid (AA) than those of normal dogs. The stimulatory effect of the synthetic endoperoxide analogue U-46619, was significantly higher in the diabetic condition t...

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Detalles Bibliográficos
Autores principales: Sterin-Borda, L., Gimeno, M., Borda, E., del Castillo, E., Gimeno, A.L.
Formato: JOUR
Materias:
15 Hydroxy 11 alpha,9 alpha (epoxymethano)prosta 5,13 dienoic Acid
15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid
acetylsalicylic acid
Anti Inflammatory Agents
antiinflammatory agent
corticosterone
imidazole
imidazole derivative
indole derivative
indometacin
nictindole
prostacyclin
prostaglandin
prostaglandin endoperoxide
pyridine derivative
arachidonic acid
endoperoxide analog
thromboxane
unclassified drug
animal
article
coronary blood vessel
dog
dose response
drug effect
experimental diabetes mellitus
kinetics
pancreas resection
pathophysiology
animal experiment
coronary artery
diabetes mellitus
dose
drug comparison
drug response
endocrine system
great blood vessel
in vitro study
vasoconstriction
vasodilatation
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Animal
Anti-Inflammatory Agents
Aspirin
Coronary Vessels
Corticosterone
Diabetes Mellitus, Experimental
Dogs
Dose-Response Relationship, Drug
Epoprostenol
Imidazoles
Indoles
Indomethacin
Kinetics
Pancreatectomy
Prostaglandin Endoperoxides, Synthetic
Prostaglandins
Pyridines
Animalia
Canis familiaris
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00906980_v22_n2_p267_SterinBorda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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