Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis
Isolated coronary arteries from diabetic dogs presented different contractile response to U-46619 to prostacyclin (PGI2) and to arachidonic acid (AA) than those of normal dogs. The stimulatory effect of the synthetic endoperoxide analogue U-46619, was significantly higher in the diabetic condition t...
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todo:paper_00906980_v22_n2_p267_SterinBorda2023-10-03T14:54:47Z Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis Sterin-Borda, L. Gimeno, M. Borda, E. del Castillo, E. Gimeno, A.L. 15 Hydroxy 11 alpha,9 alpha (epoxymethano)prosta 5,13 dienoic Acid 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid Anti Inflammatory Agents antiinflammatory agent corticosterone imidazole imidazole derivative indole derivative indometacin nictindole prostacyclin prostaglandin prostaglandin endoperoxide pyridine derivative 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid arachidonic acid endoperoxide analog imidazole indometacin nictindole prostacyclin thromboxane unclassified drug animal article coronary blood vessel dog dose response drug effect experimental diabetes mellitus kinetics pancreas resection pathophysiology animal experiment coronary artery diabetes mellitus dose drug comparison drug response endocrine system great blood vessel in vitro study vasoconstriction vasodilatation 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animal Anti-Inflammatory Agents Aspirin Coronary Vessels Corticosterone Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Imidazoles Indoles Indomethacin Kinetics Pancreatectomy Prostaglandin Endoperoxides, Synthetic Prostaglandins Pyridines Animalia Canis familiaris Isolated coronary arteries from diabetic dogs presented different contractile response to U-46619 to prostacyclin (PGI2) and to arachidonic acid (AA) than those of normal dogs. The stimulatory effect of the synthetic endoperoxide analogue U-46619, was significantly higher in the diabetic condition than in preparations from normal animals. On the other hand, while PGI2 evoked a dose-dependent relaxation of normal coronary arteries, diabetic vessels were not relaxed by low concentration of PGI2 whereas higher ones produced a distinct constrictor effect. Additionally, inhibitors of prostaglandins and thromboxane (TX) biosynthesis such as corticosterone, indomethacin, acetylsalicylic acid, imidazole and L-8027, abolished the stimulatory effect of PGI2 in coronary arteries from diabetic dogs. AA relaxed coronaries from normal dogs and constricted those from diabetic animals, this action being inhibited by imidazol and L-8027. The present results suggests that: a) coronary vessels from diabetic dogs are more reactive to an endoperoxide analogue than normal preparations and b) PGI2 and AA probably contract diabetic coronary arteries via the participation of a TX like material. It is then plausible that this effect could be tentatively ascribed to the production of a prostaglandin constricting substance including als the probable generation of a TXA2-like agonist. © 1981. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v22_n2_p267_SterinBorda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
15 Hydroxy 11 alpha,9 alpha (epoxymethano)prosta 5,13 dienoic Acid 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid Anti Inflammatory Agents antiinflammatory agent corticosterone imidazole imidazole derivative indole derivative indometacin nictindole prostacyclin prostaglandin prostaglandin endoperoxide pyridine derivative 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid arachidonic acid endoperoxide analog imidazole indometacin nictindole prostacyclin thromboxane unclassified drug animal article coronary blood vessel dog dose response drug effect experimental diabetes mellitus kinetics pancreas resection pathophysiology animal experiment coronary artery diabetes mellitus dose drug comparison drug response endocrine system great blood vessel in vitro study vasoconstriction vasodilatation 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animal Anti-Inflammatory Agents Aspirin Coronary Vessels Corticosterone Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Imidazoles Indoles Indomethacin Kinetics Pancreatectomy Prostaglandin Endoperoxides, Synthetic Prostaglandins Pyridines Animalia Canis familiaris |
| spellingShingle |
15 Hydroxy 11 alpha,9 alpha (epoxymethano)prosta 5,13 dienoic Acid 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid Anti Inflammatory Agents antiinflammatory agent corticosterone imidazole imidazole derivative indole derivative indometacin nictindole prostacyclin prostaglandin prostaglandin endoperoxide pyridine derivative 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid arachidonic acid endoperoxide analog imidazole indometacin nictindole prostacyclin thromboxane unclassified drug animal article coronary blood vessel dog dose response drug effect experimental diabetes mellitus kinetics pancreas resection pathophysiology animal experiment coronary artery diabetes mellitus dose drug comparison drug response endocrine system great blood vessel in vitro study vasoconstriction vasodilatation 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animal Anti-Inflammatory Agents Aspirin Coronary Vessels Corticosterone Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Imidazoles Indoles Indomethacin Kinetics Pancreatectomy Prostaglandin Endoperoxides, Synthetic Prostaglandins Pyridines Animalia Canis familiaris Sterin-Borda, L. Gimeno, M. Borda, E. del Castillo, E. Gimeno, A.L. Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis |
| topic_facet |
15 Hydroxy 11 alpha,9 alpha (epoxymethano)prosta 5,13 dienoic Acid 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid Anti Inflammatory Agents antiinflammatory agent corticosterone imidazole imidazole derivative indole derivative indometacin nictindole prostacyclin prostaglandin prostaglandin endoperoxide pyridine derivative 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid arachidonic acid endoperoxide analog imidazole indometacin nictindole prostacyclin thromboxane unclassified drug animal article coronary blood vessel dog dose response drug effect experimental diabetes mellitus kinetics pancreas resection pathophysiology animal experiment coronary artery diabetes mellitus dose drug comparison drug response endocrine system great blood vessel in vitro study vasoconstriction vasodilatation 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animal Anti-Inflammatory Agents Aspirin Coronary Vessels Corticosterone Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Imidazoles Indoles Indomethacin Kinetics Pancreatectomy Prostaglandin Endoperoxides, Synthetic Prostaglandins Pyridines Animalia Canis familiaris |
| description |
Isolated coronary arteries from diabetic dogs presented different contractile response to U-46619 to prostacyclin (PGI2) and to arachidonic acid (AA) than those of normal dogs. The stimulatory effect of the synthetic endoperoxide analogue U-46619, was significantly higher in the diabetic condition than in preparations from normal animals. On the other hand, while PGI2 evoked a dose-dependent relaxation of normal coronary arteries, diabetic vessels were not relaxed by low concentration of PGI2 whereas higher ones produced a distinct constrictor effect. Additionally, inhibitors of prostaglandins and thromboxane (TX) biosynthesis such as corticosterone, indomethacin, acetylsalicylic acid, imidazole and L-8027, abolished the stimulatory effect of PGI2 in coronary arteries from diabetic dogs. AA relaxed coronaries from normal dogs and constricted those from diabetic animals, this action being inhibited by imidazol and L-8027. The present results suggests that: a) coronary vessels from diabetic dogs are more reactive to an endoperoxide analogue than normal preparations and b) PGI2 and AA probably contract diabetic coronary arteries via the participation of a TX like material. It is then plausible that this effect could be tentatively ascribed to the production of a prostaglandin constricting substance including als the probable generation of a TXA2-like agonist. © 1981. |
| format |
JOUR |
| author |
Sterin-Borda, L. Gimeno, M. Borda, E. del Castillo, E. Gimeno, A.L. |
| author_facet |
Sterin-Borda, L. Gimeno, M. Borda, E. del Castillo, E. Gimeno, A.L. |
| author_sort |
Sterin-Borda, L. |
| title |
Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis |
| title_short |
Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis |
| title_full |
Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis |
| title_fullStr |
Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis |
| title_full_unstemmed |
Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis |
| title_sort |
prostacyclin (pgi2) and u-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis |
| url |
http://hdl.handle.net/20.500.12110/paper_00906980_v22_n2_p267_SterinBorda |
| work_keys_str_mv |
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1782024723918487552 |