Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms

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The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low...

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Autores principales: Sterin-Borda, L., Canga, L., Pissani, A., Gimeno, A.L.
Formato: JOUR
Materias:
Adrenergic alpha Agonists
Adrenergic beta Agonists
alpha adrenergic receptor stimulating agent
beta adrenergic receptor stimulating agent
methoxamine
noradrenalin
prostaglandin E
phenoxybenzamine
phentolamine
propranolol
prostaglandin E1
prostaglandin E2
animal
article
dose response
drug effect
heart atrium
heart contraction
in vitro study
male
rat
adrenergic system
animal experiment
autonomic nervous system
drug comparison
heart
heart atrium contraction
heart inotropic effect
inotropism
isolated heart
preliminary communication
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Animal
Dose-Response Relationship, Drug
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Prostaglandins E
Rats
Support, Non-U.S. Gov't
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00906980_v20_n5_p825_SterinBorda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00906980_v20_n5_p825_SterinBorda
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spelling todo:paper_00906980_v20_n5_p825_SterinBorda2023-10-03T14:54:46Z Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms Sterin-Borda, L. Canga, L. Pissani, A. Gimeno, A.L. Adrenergic alpha Agonists Adrenergic beta Agonists alpha adrenergic receptor stimulating agent beta adrenergic receptor stimulating agent methoxamine noradrenalin prostaglandin E methoxamine noradrenalin phenoxybenzamine phentolamine propranolol prostaglandin E1 prostaglandin E2 animal article dose response drug effect heart atrium heart contraction in vitro study male rat adrenergic system animal experiment autonomic nervous system drug comparison heart heart atrium heart atrium contraction heart contraction heart inotropic effect inotropism isolated heart preliminary communication Adrenergic alpha-Agonists Adrenergic beta-Agonists Animal Dose-Response Relationship, Drug Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Prostaglandins E Rats Support, Non-U.S. Gov't Animalia The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low concentrations and positive (PIE) at higher ones. Phenoxybenzamine and phentolamine failed to modify either the NIE or the PIE, but subthreshold exogenous norepinephrine abolished the NIE, suggesting a presynaptic inhibitory effect of PGEs on the adrenergic neurotransmitter release. Auricles pretreated with subthreshold norepinephrine react with a PIE to PGE1, but not to PGE2. On the contrary in the presence of subthreshold methoxamine the PIE of PGE2 was increased whereas the action of PGE1 was not modified. © 1980, All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v20_n5_p825_SterinBorda
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Adrenergic alpha Agonists
Adrenergic beta Agonists
alpha adrenergic receptor stimulating agent
beta adrenergic receptor stimulating agent
methoxamine
noradrenalin
prostaglandin E
methoxamine
noradrenalin
phenoxybenzamine
phentolamine
propranolol
prostaglandin E1
prostaglandin E2
animal
article
dose response
drug effect
heart atrium
heart contraction
in vitro study
male
rat
adrenergic system
animal experiment
autonomic nervous system
drug comparison
heart
heart atrium
heart atrium contraction
heart contraction
heart inotropic effect
inotropism
isolated heart
preliminary communication
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Animal
Dose-Response Relationship, Drug
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Prostaglandins E
Rats
Support, Non-U.S. Gov't
Animalia
spellingShingle Adrenergic alpha Agonists
Adrenergic beta Agonists
alpha adrenergic receptor stimulating agent
beta adrenergic receptor stimulating agent
methoxamine
noradrenalin
prostaglandin E
methoxamine
noradrenalin
phenoxybenzamine
phentolamine
propranolol
prostaglandin E1
prostaglandin E2
animal
article
dose response
drug effect
heart atrium
heart contraction
in vitro study
male
rat
adrenergic system
animal experiment
autonomic nervous system
drug comparison
heart
heart atrium
heart atrium contraction
heart contraction
heart inotropic effect
inotropism
isolated heart
preliminary communication
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Animal
Dose-Response Relationship, Drug
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Prostaglandins E
Rats
Support, Non-U.S. Gov't
Animalia
Sterin-Borda, L.
Canga, L.
Pissani, A.
Gimeno, A.L.
Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
topic_facet Adrenergic alpha Agonists
Adrenergic beta Agonists
alpha adrenergic receptor stimulating agent
beta adrenergic receptor stimulating agent
methoxamine
noradrenalin
prostaglandin E
methoxamine
noradrenalin
phenoxybenzamine
phentolamine
propranolol
prostaglandin E1
prostaglandin E2
animal
article
dose response
drug effect
heart atrium
heart contraction
in vitro study
male
rat
adrenergic system
animal experiment
autonomic nervous system
drug comparison
heart
heart atrium
heart atrium contraction
heart contraction
heart inotropic effect
inotropism
isolated heart
preliminary communication
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Animal
Dose-Response Relationship, Drug
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Prostaglandins E
Rats
Support, Non-U.S. Gov't
Animalia
description The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low concentrations and positive (PIE) at higher ones. Phenoxybenzamine and phentolamine failed to modify either the NIE or the PIE, but subthreshold exogenous norepinephrine abolished the NIE, suggesting a presynaptic inhibitory effect of PGEs on the adrenergic neurotransmitter release. Auricles pretreated with subthreshold norepinephrine react with a PIE to PGE1, but not to PGE2. On the contrary in the presence of subthreshold methoxamine the PIE of PGE2 was increased whereas the action of PGE1 was not modified. © 1980, All rights reserved.
format JOUR
author Sterin-Borda, L.
Canga, L.
Pissani, A.
Gimeno, A.L.
author_facet Sterin-Borda, L.
Canga, L.
Pissani, A.
Gimeno, A.L.
author_sort Sterin-Borda, L.
title Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
title_short Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
title_full Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
title_fullStr Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
title_full_unstemmed Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
title_sort inotropic effect of pge1 and pge2 on isolated rat atria. influence of adrenergic mechanisms
url http://hdl.handle.net/20.500.12110/paper_00906980_v20_n5_p825_SterinBorda
work_keys_str_mv AT sterinbordal inotropiceffectofpge1andpge2onisolatedratatriainfluenceofadrenergicmechanisms
AT cangal inotropiceffectofpge1andpge2onisolatedratatriainfluenceofadrenergicmechanisms
AT pissania inotropiceffectofpge1andpge2onisolatedratatriainfluenceofadrenergicmechanisms
AT gimenoal inotropiceffectofpge1andpge2onisolatedratatriainfluenceofadrenergicmechanisms
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