The effect of estradiol on isolated rat uterine motility and on prostaglandin generation
The motility of isolated uterine horns as well as the generation of PGE and PGF like material by the uterus from estrus and spayed rats, treated or untreated with 17-beta estradicl, were studied. Following 40 minutes of mounting the spontaneous motility of uteri from estrus rats had a lower magnitud...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00906980_v20_n2_p233_SterinSpeziale |
| Aporte de: |
| id |
todo:paper_00906980_v20_n2_p233_SterinSpeziale |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_00906980_v20_n2_p233_SterinSpeziale2023-10-03T14:54:46Z The effect of estradiol on isolated rat uterine motility and on prostaglandin generation Sterin-Speziale, N. Gimeno, M.F. Bonacossa, A. Gimeno, A.L. estradiol prostaglandin prostaglandin e prostaglandin f animal experiment female genital system preliminary communication rat subcutaneous drug administration uterus uterus contractility Animal Castration Dose-Response Relationship, Drug Estradiol Estrus Female Pregnancy Prostaglandins E Prostaglandins F Rats Uterine Contraction Uterus The motility of isolated uterine horns as well as the generation of PGE and PGF like material by the uterus from estrus and spayed rats, treated or untreated with 17-beta estradicl, were studied. Following 40 minutes of mounting the spontaneous motility of uteri from estrus rats had a lower magnitude than that from spayed ones. The amount of PGF-like material was similar in both groups whereas the first one liberated less PGE-like substance. In spayed animals treated with 1 μg of 17-beta estradiol the decay of spontaneous contractile force was higher than that observed in untreated rats, and similar to that displayed by uteri from estrus. Less PGE-like material was liberated in comparison with spayed animals and a tendency to produce higher quantity of PGF-like compounds was observed, although the level was not significantly different. With 50 μg of 17-beta estradiol the spontaneous reduction of contractile activity was higher than in spayed animals and than in those treated with 1 μg. The amount of PGF-like material liberated was higher than in spayed rats and less PGE-like substance was generated comparing with spayed and 1 μg-treated animals. These findings show that estradiol decreases the release of PGE-like compound. It would also appear that this may have some relationship with the levels of spontaneous contractile activity of the isolated rat uterus. © 1980. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v20_n2_p233_SterinSpeziale |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
estradiol prostaglandin prostaglandin e prostaglandin f animal experiment female genital system preliminary communication rat subcutaneous drug administration uterus uterus contractility Animal Castration Dose-Response Relationship, Drug Estradiol Estrus Female Pregnancy Prostaglandins E Prostaglandins F Rats Uterine Contraction Uterus |
| spellingShingle |
estradiol prostaglandin prostaglandin e prostaglandin f animal experiment female genital system preliminary communication rat subcutaneous drug administration uterus uterus contractility Animal Castration Dose-Response Relationship, Drug Estradiol Estrus Female Pregnancy Prostaglandins E Prostaglandins F Rats Uterine Contraction Uterus Sterin-Speziale, N. Gimeno, M.F. Bonacossa, A. Gimeno, A.L. The effect of estradiol on isolated rat uterine motility and on prostaglandin generation |
| topic_facet |
estradiol prostaglandin prostaglandin e prostaglandin f animal experiment female genital system preliminary communication rat subcutaneous drug administration uterus uterus contractility Animal Castration Dose-Response Relationship, Drug Estradiol Estrus Female Pregnancy Prostaglandins E Prostaglandins F Rats Uterine Contraction Uterus |
| description |
The motility of isolated uterine horns as well as the generation of PGE and PGF like material by the uterus from estrus and spayed rats, treated or untreated with 17-beta estradicl, were studied. Following 40 minutes of mounting the spontaneous motility of uteri from estrus rats had a lower magnitude than that from spayed ones. The amount of PGF-like material was similar in both groups whereas the first one liberated less PGE-like substance. In spayed animals treated with 1 μg of 17-beta estradiol the decay of spontaneous contractile force was higher than that observed in untreated rats, and similar to that displayed by uteri from estrus. Less PGE-like material was liberated in comparison with spayed animals and a tendency to produce higher quantity of PGF-like compounds was observed, although the level was not significantly different. With 50 μg of 17-beta estradiol the spontaneous reduction of contractile activity was higher than in spayed animals and than in those treated with 1 μg. The amount of PGF-like material liberated was higher than in spayed rats and less PGE-like substance was generated comparing with spayed and 1 μg-treated animals. These findings show that estradiol decreases the release of PGE-like compound. It would also appear that this may have some relationship with the levels of spontaneous contractile activity of the isolated rat uterus. © 1980. |
| format |
JOUR |
| author |
Sterin-Speziale, N. Gimeno, M.F. Bonacossa, A. Gimeno, A.L. |
| author_facet |
Sterin-Speziale, N. Gimeno, M.F. Bonacossa, A. Gimeno, A.L. |
| author_sort |
Sterin-Speziale, N. |
| title |
The effect of estradiol on isolated rat uterine motility and on prostaglandin generation |
| title_short |
The effect of estradiol on isolated rat uterine motility and on prostaglandin generation |
| title_full |
The effect of estradiol on isolated rat uterine motility and on prostaglandin generation |
| title_fullStr |
The effect of estradiol on isolated rat uterine motility and on prostaglandin generation |
| title_full_unstemmed |
The effect of estradiol on isolated rat uterine motility and on prostaglandin generation |
| title_sort |
effect of estradiol on isolated rat uterine motility and on prostaglandin generation |
| url |
http://hdl.handle.net/20.500.12110/paper_00906980_v20_n2_p233_SterinSpeziale |
| work_keys_str_mv |
AT sterinspezialen theeffectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration AT gimenomf theeffectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration AT bonacossaa theeffectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration AT gimenoal theeffectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration AT sterinspezialen effectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration AT gimenomf effectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration AT bonacossaa effectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration AT gimenoal effectofestradiolonisolatedratuterinemotilityandonprostaglandingeneration |
| _version_ |
1782025589927968768 |