Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae
Endocrine-disrupting chemicals can influence the hypothalamus-pituitary- gonad axis and possibly affect reproduction in vertebrates. We analyzed the effect of 30-day endosulfan (ES) exposure in sexually undifferentiated larvae of the cichlid fish Cichlasoma dimerus. The number, area, mean cytoplasmi...
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todo:paper_00904341_v61_n2_p300_Piazza2023-10-03T14:54:36Z Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae Piazza, Y.G. Pandolfi, M. Lo Nostro, F.L. endosulfan follitropin beta subunit gonadorelin cell organelle concentration (composition) developmental biology diameter endocrine disruptor endosulfan fish functional morphology hormone larva organochlorine physiological response pollution exposure population structure reproduction article cell population Cichlasoma dimerus cichlid controlled study cytoplasm gonad development larva nonhuman nucleus accumbens optical density priority journal protein secretion protein synthesis Animals Cichlids Endosulfan Environmental Exposure Follicle Stimulating Hormone Gonadotrophs Gonadotropin-Releasing Hormone Gonads Hydrocarbons, Chlorinated Insecticides Larva Neurons Animalia Cichlasoma Cichlidae Vertebrata Endocrine-disrupting chemicals can influence the hypothalamus-pituitary- gonad axis and possibly affect reproduction in vertebrates. We analyzed the effect of 30-day endosulfan (ES) exposure in sexually undifferentiated larvae of the cichlid fish Cichlasoma dimerus. The number, area, mean cytoplasmic and nuclear diameter, and mean cytoplasmic optical density of gonadotropin-releasing hormone (GnRH) I, II, and III immunoreactive (ir-) neurons and β follicle-stimulating hormone (βFSH) ir-cells were measured. Animals exposed to the highest ES concentration (0.1 μg/l) showed a decrease in GnRH I nucleus/cytoplasm area ratio upon exposure. Nuclear area and mean nuclear diameter of βFSH ir-cells was higher in ES treated fish. βFSH nucleus/cytoplasm area ratio was high in exposed animals, and animals exposed to 0.1 μg/l ES showed smaller mean cytoplasmic optical density. These findings suggest that ES affects GnRH I and βFSH protein synthesis/release. However, these responses seem to be insufficient to affect gonadal differentiation at this stage of development. © 2010 Springer Science+Business Media, LLC. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00904341_v61_n2_p300_Piazza |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
endosulfan follitropin beta subunit gonadorelin cell organelle concentration (composition) developmental biology diameter endocrine disruptor endosulfan fish functional morphology hormone larva organochlorine physiological response pollution exposure population structure reproduction article cell population Cichlasoma dimerus cichlid controlled study cytoplasm gonad development larva nonhuman nucleus accumbens optical density priority journal protein secretion protein synthesis Animals Cichlids Endosulfan Environmental Exposure Follicle Stimulating Hormone Gonadotrophs Gonadotropin-Releasing Hormone Gonads Hydrocarbons, Chlorinated Insecticides Larva Neurons Animalia Cichlasoma Cichlidae Vertebrata |
| spellingShingle |
endosulfan follitropin beta subunit gonadorelin cell organelle concentration (composition) developmental biology diameter endocrine disruptor endosulfan fish functional morphology hormone larva organochlorine physiological response pollution exposure population structure reproduction article cell population Cichlasoma dimerus cichlid controlled study cytoplasm gonad development larva nonhuman nucleus accumbens optical density priority journal protein secretion protein synthesis Animals Cichlids Endosulfan Environmental Exposure Follicle Stimulating Hormone Gonadotrophs Gonadotropin-Releasing Hormone Gonads Hydrocarbons, Chlorinated Insecticides Larva Neurons Animalia Cichlasoma Cichlidae Vertebrata Piazza, Y.G. Pandolfi, M. Lo Nostro, F.L. Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae |
| topic_facet |
endosulfan follitropin beta subunit gonadorelin cell organelle concentration (composition) developmental biology diameter endocrine disruptor endosulfan fish functional morphology hormone larva organochlorine physiological response pollution exposure population structure reproduction article cell population Cichlasoma dimerus cichlid controlled study cytoplasm gonad development larva nonhuman nucleus accumbens optical density priority journal protein secretion protein synthesis Animals Cichlids Endosulfan Environmental Exposure Follicle Stimulating Hormone Gonadotrophs Gonadotropin-Releasing Hormone Gonads Hydrocarbons, Chlorinated Insecticides Larva Neurons Animalia Cichlasoma Cichlidae Vertebrata |
| description |
Endocrine-disrupting chemicals can influence the hypothalamus-pituitary- gonad axis and possibly affect reproduction in vertebrates. We analyzed the effect of 30-day endosulfan (ES) exposure in sexually undifferentiated larvae of the cichlid fish Cichlasoma dimerus. The number, area, mean cytoplasmic and nuclear diameter, and mean cytoplasmic optical density of gonadotropin-releasing hormone (GnRH) I, II, and III immunoreactive (ir-) neurons and β follicle-stimulating hormone (βFSH) ir-cells were measured. Animals exposed to the highest ES concentration (0.1 μg/l) showed a decrease in GnRH I nucleus/cytoplasm area ratio upon exposure. Nuclear area and mean nuclear diameter of βFSH ir-cells was higher in ES treated fish. βFSH nucleus/cytoplasm area ratio was high in exposed animals, and animals exposed to 0.1 μg/l ES showed smaller mean cytoplasmic optical density. These findings suggest that ES affects GnRH I and βFSH protein synthesis/release. However, these responses seem to be insufficient to affect gonadal differentiation at this stage of development. © 2010 Springer Science+Business Media, LLC. |
| format |
JOUR |
| author |
Piazza, Y.G. Pandolfi, M. Lo Nostro, F.L. |
| author_facet |
Piazza, Y.G. Pandolfi, M. Lo Nostro, F.L. |
| author_sort |
Piazza, Y.G. |
| title |
Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae |
| title_short |
Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae |
| title_full |
Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae |
| title_fullStr |
Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae |
| title_full_unstemmed |
Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae |
| title_sort |
effect of the organochlorine pesticide endosulfan on gnrh and gonadotrope cell populations in fish larvae |
| url |
http://hdl.handle.net/20.500.12110/paper_00904341_v61_n2_p300_Piazza |
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