Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease
It is demonstrated that murine chagasic IgG and the corresponding F(ab′)2 fragments interfere with β adrenergic and muscarinic cholinergic specific ligand occupancy on T cell-enriched population. From the interaction between chagasic IgG or F(ab′)2 with Lyt-1+ cells, an increase in cAMP levels occur...
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todo:paper_00901229_v55_n2_p221_Gorelik2023-10-03T14:54:32Z Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease Gorelik, G. Genaro, A.M. Sterin-Borda, L. Cappa, S.G. Borda, E.S. beta adrenergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g prostaglandin e2 animal experiment article chagas disease mouse myocarditis nonhuman priority journal protozoon trypanosoma cruzi Animal Atrial Function Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Immunoglobulin G Immunoglobulins, Fab Lymphocytes Mice Mice, Inbred BALB C Myocardial Contraction Protein Binding Receptors, Adrenergic, beta Receptors, Cholinergic Support, Non-U.S. Gov't T-Lymphocytes Thromboxane B2 It is demonstrated that murine chagasic IgG and the corresponding F(ab′)2 fragments interfere with β adrenergic and muscarinic cholinergic specific ligand occupancy on T cell-enriched population. From the interaction between chagasic IgG or F(ab′)2 with Lyt-1+ cells, an increase in cAMP levels occurs as a consequence of β adrenergic receptor activation. On the contrary, chagasic IgG or F(ab′)2 interactions with Lyt-2+ cells induce an activation of muscarinic cholinergic receptor, leading to an increment in cGMP. Muscarinic cholinergic and β adrenergic stimulation trigger the release of PGE2 and TXB2, respectively. Lyt-2+ cells treated with chagasic IgG or F(ab′)2 are able to decrease the contractility of mouse atria. The same negative inotropic effect is elicited with Lyt-2+ cells from Trypanosoma cruzi-infected mice susceptible to developed myocarditis. The implications of these results in the pathogenesis of Chagas' myocarditis are discussed. © 1990. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00901229_v55_n2_p221_Gorelik |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
beta adrenergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g prostaglandin e2 animal experiment article chagas disease mouse myocarditis nonhuman priority journal protozoon trypanosoma cruzi Animal Atrial Function Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Immunoglobulin G Immunoglobulins, Fab Lymphocytes Mice Mice, Inbred BALB C Myocardial Contraction Protein Binding Receptors, Adrenergic, beta Receptors, Cholinergic Support, Non-U.S. Gov't T-Lymphocytes Thromboxane B2 |
| spellingShingle |
beta adrenergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g prostaglandin e2 animal experiment article chagas disease mouse myocarditis nonhuman priority journal protozoon trypanosoma cruzi Animal Atrial Function Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Immunoglobulin G Immunoglobulins, Fab Lymphocytes Mice Mice, Inbred BALB C Myocardial Contraction Protein Binding Receptors, Adrenergic, beta Receptors, Cholinergic Support, Non-U.S. Gov't T-Lymphocytes Thromboxane B2 Gorelik, G. Genaro, A.M. Sterin-Borda, L. Cappa, S.G. Borda, E.S. Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease |
| topic_facet |
beta adrenergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g prostaglandin e2 animal experiment article chagas disease mouse myocarditis nonhuman priority journal protozoon trypanosoma cruzi Animal Atrial Function Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Immunoglobulin G Immunoglobulins, Fab Lymphocytes Mice Mice, Inbred BALB C Myocardial Contraction Protein Binding Receptors, Adrenergic, beta Receptors, Cholinergic Support, Non-U.S. Gov't T-Lymphocytes Thromboxane B2 |
| description |
It is demonstrated that murine chagasic IgG and the corresponding F(ab′)2 fragments interfere with β adrenergic and muscarinic cholinergic specific ligand occupancy on T cell-enriched population. From the interaction between chagasic IgG or F(ab′)2 with Lyt-1+ cells, an increase in cAMP levels occurs as a consequence of β adrenergic receptor activation. On the contrary, chagasic IgG or F(ab′)2 interactions with Lyt-2+ cells induce an activation of muscarinic cholinergic receptor, leading to an increment in cGMP. Muscarinic cholinergic and β adrenergic stimulation trigger the release of PGE2 and TXB2, respectively. Lyt-2+ cells treated with chagasic IgG or F(ab′)2 are able to decrease the contractility of mouse atria. The same negative inotropic effect is elicited with Lyt-2+ cells from Trypanosoma cruzi-infected mice susceptible to developed myocarditis. The implications of these results in the pathogenesis of Chagas' myocarditis are discussed. © 1990. |
| format |
JOUR |
| author |
Gorelik, G. Genaro, A.M. Sterin-Borda, L. Cappa, S.G. Borda, E.S. |
| author_facet |
Gorelik, G. Genaro, A.M. Sterin-Borda, L. Cappa, S.G. Borda, E.S. |
| author_sort |
Gorelik, G. |
| title |
Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease |
| title_short |
Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease |
| title_full |
Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease |
| title_fullStr |
Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease |
| title_full_unstemmed |
Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease |
| title_sort |
antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in chagas' disease |
| url |
http://hdl.handle.net/20.500.12110/paper_00901229_v55_n2_p221_Gorelik |
| work_keys_str_mv |
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| _version_ |
1807322876474294272 |