Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide
A network of cell–cell communications through contact and soluble factors supports the maternal–placental interaction and provides a suitable environment for fetal growth. Trophoblast cells take center stage at these loops: they interact with maternal leukocytes to sustain the varying demands of ges...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00778923_v1437_n1_p15_Ramhorst |
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todo:paper_00778923_v1437_n1_p15_Ramhorst2023-10-03T14:54:21Z Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide Ramhorst, R. Calo, G. Paparini, D. Vota, D. Hauk, V. Gallino, L. Merech, F. Grasso, E. Leirós, C.P. Immune homeostasis Pregnancy Trophoblast cell lines Vasoactive intestinal polypeptide vasoactive intestinal polypeptide apoptosis cell population disease control extracellular trap homeostasis human inflammation macrophage monocyte neutrophil phagocyte pregnancy pregnancy complication regulatory T lymphocyte Review trophoblast A network of cell–cell communications through contact and soluble factors supports the maternal–placental interaction and provides a suitable environment for fetal growth. Trophoblast cells take center stage at these loops: they interact with maternal leukocytes to sustain the varying demands of gestation, and they synthesize hormones, cytokines among other factors that contribute to the maintenance of immune homeostasis. Here, we discuss vasoactive intestinal peptide (VIP) and its potential as a regulatory neuropeptide in pregnancy. VIP is synthesized by trophoblast cells; it regulates trophoblast cell function and interaction with the major immune cell populations present in the pregnant uterus. VIP activity produces an anti-inflammatory microenvironment by modulating the functional profile of monocytes, macrophages, and regulatory T cells. Trophoblast VIP inhibits neutrophil extracellular trap formation and accelerates neutrophil apoptosis, enabling their silent clearance by phagocytic cells. The effects of VIP on the trophoblast–immune interaction are consistent with its regulatory role throughout pregnancy for immune homeostasis maintenance. These observations may provide new clues for pharmacological targeting of pregnancy complications associated with exacerbated inflammation. © 2018 New York Academy of Sciences. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00778923_v1437_n1_p15_Ramhorst |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Immune homeostasis Pregnancy Trophoblast cell lines Vasoactive intestinal polypeptide vasoactive intestinal polypeptide apoptosis cell population disease control extracellular trap homeostasis human inflammation macrophage monocyte neutrophil phagocyte pregnancy pregnancy complication regulatory T lymphocyte Review trophoblast |
| spellingShingle |
Immune homeostasis Pregnancy Trophoblast cell lines Vasoactive intestinal polypeptide vasoactive intestinal polypeptide apoptosis cell population disease control extracellular trap homeostasis human inflammation macrophage monocyte neutrophil phagocyte pregnancy pregnancy complication regulatory T lymphocyte Review trophoblast Ramhorst, R. Calo, G. Paparini, D. Vota, D. Hauk, V. Gallino, L. Merech, F. Grasso, E. Leirós, C.P. Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide |
| topic_facet |
Immune homeostasis Pregnancy Trophoblast cell lines Vasoactive intestinal polypeptide vasoactive intestinal polypeptide apoptosis cell population disease control extracellular trap homeostasis human inflammation macrophage monocyte neutrophil phagocyte pregnancy pregnancy complication regulatory T lymphocyte Review trophoblast |
| description |
A network of cell–cell communications through contact and soluble factors supports the maternal–placental interaction and provides a suitable environment for fetal growth. Trophoblast cells take center stage at these loops: they interact with maternal leukocytes to sustain the varying demands of gestation, and they synthesize hormones, cytokines among other factors that contribute to the maintenance of immune homeostasis. Here, we discuss vasoactive intestinal peptide (VIP) and its potential as a regulatory neuropeptide in pregnancy. VIP is synthesized by trophoblast cells; it regulates trophoblast cell function and interaction with the major immune cell populations present in the pregnant uterus. VIP activity produces an anti-inflammatory microenvironment by modulating the functional profile of monocytes, macrophages, and regulatory T cells. Trophoblast VIP inhibits neutrophil extracellular trap formation and accelerates neutrophil apoptosis, enabling their silent clearance by phagocytic cells. The effects of VIP on the trophoblast–immune interaction are consistent with its regulatory role throughout pregnancy for immune homeostasis maintenance. These observations may provide new clues for pharmacological targeting of pregnancy complications associated with exacerbated inflammation. © 2018 New York Academy of Sciences. |
| format |
JOUR |
| author |
Ramhorst, R. Calo, G. Paparini, D. Vota, D. Hauk, V. Gallino, L. Merech, F. Grasso, E. Leirós, C.P. |
| author_facet |
Ramhorst, R. Calo, G. Paparini, D. Vota, D. Hauk, V. Gallino, L. Merech, F. Grasso, E. Leirós, C.P. |
| author_sort |
Ramhorst, R. |
| title |
Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide |
| title_short |
Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide |
| title_full |
Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide |
| title_fullStr |
Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide |
| title_full_unstemmed |
Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide |
| title_sort |
control of the inflammatory response during pregnancy: potential role of vip as a regulatory peptide |
| url |
http://hdl.handle.net/20.500.12110/paper_00778923_v1437_n1_p15_Ramhorst |
| work_keys_str_mv |
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