Polyhydroxyalkanoates: Much More than Biodegradable Plastics

Bacterial polyhydroxyalkanoates (PHAs) are isotactic polymers that play a critical role in central metabolism, as they act as dynamic reservoirs of carbon and reducing equivalents. These polymers have a number of technical applications since they exhibit thermoplastic and elastomeric properties, mak...

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Autores principales:	López, N.I., Pettinari, M.J., Nikel, P.I., Méndez, B.S., Gadd G.M., Sariaslani S.
Formato:	SER
Materias:	Bacteria Bacterial ecology Central metabolism Global regulation Polyhydroxyalkanoates biodegradable plastic glycogen peptides and proteins polyhydroxyalkanoic acid polymer protein gaca protein gacs unclassified drug biofilm bioremediation catabolite repression cold tolerance degradation Escherichia coli gene nonhuman oxidation reduction reaction plant growth polyhydroxyalkanoic acid gene Pseudomonas signal transduction stress survival synthesis genetics metabolism Pseudomonas putida Biodegradable Plastics Biodegradation, Environmental
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00652164_v93_n_p73_Lopez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00652164_v93_n_p73_Lopez
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spelling	todo:paper_00652164_v93_n_p73_Lopez2023-10-03T14:52:47Z Polyhydroxyalkanoates: Much More than Biodegradable Plastics López, N.I. Pettinari, M.J. Nikel, P.I. Méndez, B.S. Gadd G.M. Sariaslani S. Bacteria Bacterial ecology Central metabolism Global regulation Polyhydroxyalkanoates biodegradable plastic glycogen peptides and proteins polyhydroxyalkanoic acid polymer protein gaca protein gacs unclassified drug biodegradable plastic polyhydroxyalkanoic acid biofilm bioremediation catabolite repression cold tolerance degradation Escherichia coli gene nonhuman oxidation reduction reaction plant growth polyhydroxyalkanoic acid gene Pseudomonas signal transduction stress survival synthesis genetics metabolism Pseudomonas putida Biodegradable Plastics Biodegradation, Environmental Escherichia coli Polyhydroxyalkanoates Pseudomonas putida Bacterial polyhydroxyalkanoates (PHAs) are isotactic polymers that play a critical role in central metabolism, as they act as dynamic reservoirs of carbon and reducing equivalents. These polymers have a number of technical applications since they exhibit thermoplastic and elastomeric properties, making them attractive as a replacement of oil-derived materials. PHAs are accumulated under conditions of nutritional imbalance (usually an excess of carbon source with respect to a limiting nutrient, such as nitrogen or phosphorus). The cycle of PHA synthesis and degradation has been recognized as an important physiological feature when these biochemical pathways were originally described, yet its role in bacterial processes as diverse as global regulation and cell survival is just starting to be appreciated in full. In the present revision, the complex regulation of PHA synthesis and degradation at the transcriptional, translational, and metabolic levels are explored by analyzing examples in natural producer bacteria, such as Pseudomonas species, as well as in recombinant Escherichia coli strains. The ecological role of PHAs, together with the interrelations with other polymers and extracellular substances, is also discussed, along with their importance in cell survival, resistance to several types of environmental stress, and planktonic-versus-biofilm lifestyle. Finally, bioremediation and plant growth promotion are presented as examples of environmental applications in which PHA accumulation has successfully been exploited. © 2015 Elsevier Inc.. Fil:Méndez, B.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00652164_v93_n_p73_Lopez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Bacteria Bacterial ecology Central metabolism Global regulation Polyhydroxyalkanoates biodegradable plastic glycogen peptides and proteins polyhydroxyalkanoic acid polymer protein gaca protein gacs unclassified drug biodegradable plastic polyhydroxyalkanoic acid biofilm bioremediation catabolite repression cold tolerance degradation Escherichia coli gene nonhuman oxidation reduction reaction plant growth polyhydroxyalkanoic acid gene Pseudomonas signal transduction stress survival synthesis genetics metabolism Pseudomonas putida Biodegradable Plastics Biodegradation, Environmental Escherichia coli Polyhydroxyalkanoates Pseudomonas putida
spellingShingle	Bacteria Bacterial ecology Central metabolism Global regulation Polyhydroxyalkanoates biodegradable plastic glycogen peptides and proteins polyhydroxyalkanoic acid polymer protein gaca protein gacs unclassified drug biodegradable plastic polyhydroxyalkanoic acid biofilm bioremediation catabolite repression cold tolerance degradation Escherichia coli gene nonhuman oxidation reduction reaction plant growth polyhydroxyalkanoic acid gene Pseudomonas signal transduction stress survival synthesis genetics metabolism Pseudomonas putida Biodegradable Plastics Biodegradation, Environmental Escherichia coli Polyhydroxyalkanoates Pseudomonas putida López, N.I. Pettinari, M.J. Nikel, P.I. Méndez, B.S. Gadd G.M. Sariaslani S. Polyhydroxyalkanoates: Much More than Biodegradable Plastics
topic_facet	Bacteria Bacterial ecology Central metabolism Global regulation Polyhydroxyalkanoates biodegradable plastic glycogen peptides and proteins polyhydroxyalkanoic acid polymer protein gaca protein gacs unclassified drug biodegradable plastic polyhydroxyalkanoic acid biofilm bioremediation catabolite repression cold tolerance degradation Escherichia coli gene nonhuman oxidation reduction reaction plant growth polyhydroxyalkanoic acid gene Pseudomonas signal transduction stress survival synthesis genetics metabolism Pseudomonas putida Biodegradable Plastics Biodegradation, Environmental Escherichia coli Polyhydroxyalkanoates Pseudomonas putida
description	Bacterial polyhydroxyalkanoates (PHAs) are isotactic polymers that play a critical role in central metabolism, as they act as dynamic reservoirs of carbon and reducing equivalents. These polymers have a number of technical applications since they exhibit thermoplastic and elastomeric properties, making them attractive as a replacement of oil-derived materials. PHAs are accumulated under conditions of nutritional imbalance (usually an excess of carbon source with respect to a limiting nutrient, such as nitrogen or phosphorus). The cycle of PHA synthesis and degradation has been recognized as an important physiological feature when these biochemical pathways were originally described, yet its role in bacterial processes as diverse as global regulation and cell survival is just starting to be appreciated in full. In the present revision, the complex regulation of PHA synthesis and degradation at the transcriptional, translational, and metabolic levels are explored by analyzing examples in natural producer bacteria, such as Pseudomonas species, as well as in recombinant Escherichia coli strains. The ecological role of PHAs, together with the interrelations with other polymers and extracellular substances, is also discussed, along with their importance in cell survival, resistance to several types of environmental stress, and planktonic-versus-biofilm lifestyle. Finally, bioremediation and plant growth promotion are presented as examples of environmental applications in which PHA accumulation has successfully been exploited. © 2015 Elsevier Inc..
format	SER
author	López, N.I. Pettinari, M.J. Nikel, P.I. Méndez, B.S. Gadd G.M. Sariaslani S.
author_facet	López, N.I. Pettinari, M.J. Nikel, P.I. Méndez, B.S. Gadd G.M. Sariaslani S.
author_sort	López, N.I.
title	Polyhydroxyalkanoates: Much More than Biodegradable Plastics
title_short	Polyhydroxyalkanoates: Much More than Biodegradable Plastics
title_full	Polyhydroxyalkanoates: Much More than Biodegradable Plastics
title_fullStr	Polyhydroxyalkanoates: Much More than Biodegradable Plastics
title_full_unstemmed	Polyhydroxyalkanoates: Much More than Biodegradable Plastics
title_sort	polyhydroxyalkanoates: much more than biodegradable plastics
url	http://hdl.handle.net/20.500.12110/paper_00652164_v93_n_p73_Lopez
work_keys_str_mv	AT lopezni polyhydroxyalkanoatesmuchmorethanbiodegradableplastics AT pettinarimj polyhydroxyalkanoatesmuchmorethanbiodegradableplastics AT nikelpi polyhydroxyalkanoatesmuchmorethanbiodegradableplastics AT mendezbs polyhydroxyalkanoatesmuchmorethanbiodegradableplastics AT gaddgm polyhydroxyalkanoatesmuchmorethanbiodegradableplastics AT sariaslanis polyhydroxyalkanoatesmuchmorethanbiodegradableplastics
_version_	1782024063422562304

Polyhydroxyalkanoates: Much More than Biodegradable Plastics

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