Synthesis of C-C bonded dimeric steroids by olefin metathesis
Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 m...
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todo:paper_00404020_v65_n18_p3615_Edelsztein2023-10-03T14:50:44Z Synthesis of C-C bonded dimeric steroids by olefin metathesis Edelsztein, V.C. Di Chenna, P.H. Burton, G. Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 mol %). Due to the bulky nature of the steroidal skeleton the more favorable E-dimers were formed as the sole or major products depending on the linker length. © 2009 Elsevier Ltd. All rights reserved. Fil:Edelsztein, V.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Di Chenna, P.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00404020_v65_n18_p3615_Edelsztein |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis |
| spellingShingle |
Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis Edelsztein, V.C. Di Chenna, P.H. Burton, G. Synthesis of C-C bonded dimeric steroids by olefin metathesis |
| topic_facet |
Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis |
| description |
Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 mol %). Due to the bulky nature of the steroidal skeleton the more favorable E-dimers were formed as the sole or major products depending on the linker length. © 2009 Elsevier Ltd. All rights reserved. |
| format |
JOUR |
| author |
Edelsztein, V.C. Di Chenna, P.H. Burton, G. |
| author_facet |
Edelsztein, V.C. Di Chenna, P.H. Burton, G. |
| author_sort |
Edelsztein, V.C. |
| title |
Synthesis of C-C bonded dimeric steroids by olefin metathesis |
| title_short |
Synthesis of C-C bonded dimeric steroids by olefin metathesis |
| title_full |
Synthesis of C-C bonded dimeric steroids by olefin metathesis |
| title_fullStr |
Synthesis of C-C bonded dimeric steroids by olefin metathesis |
| title_full_unstemmed |
Synthesis of C-C bonded dimeric steroids by olefin metathesis |
| title_sort |
synthesis of c-c bonded dimeric steroids by olefin metathesis |
| url |
http://hdl.handle.net/20.500.12110/paper_00404020_v65_n18_p3615_Edelsztein |
| work_keys_str_mv |
AT edelszteinvc synthesisofccbondeddimericsteroidsbyolefinmetathesis AT dichennaph synthesisofccbondeddimericsteroidsbyolefinmetathesis AT burtong synthesisofccbondeddimericsteroidsbyolefinmetathesis |
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1807322639294791680 |