A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone d...
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Autores principales: | , |
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Formato: | JOUR |
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Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00397911_v23_n8_p1111_Revelli |
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Sumario: | The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone derivative (2). © 1993, Taylor & Francis Group, LLC. All rights reserved. |
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