Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin

Acid instillation into the duodenum inhibits basal and stimulated gastric secretion. In man vagotomy suppresses this secretory inhibition. It is postulated that such inhibition responds to a dual mechanism: an hormonal one (enterogastrone) and a nervous one (vagus nerve). This study showed that preo...

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Autores principales: Linares, C.A., Falasca, C.A., Sartorio, G.C., Soto, R.J.
Formato: JOUR
Materias:
gastrin
duodenum acidification
duodenum ulcer
enterogastrone
etiology
major clinical study
stomach secretion
therapy
vagotomy
vagus nerve
Duodenum
Gastric Juice
Gastrins
Human
Hydrochloric Acid
Hydrogen-Ion Concentration
Middle Age
Vagotomy
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00396060_v81_n4_p392_Linares
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00396060_v81_n4_p392_Linares2023-10-03T14:49:52Z Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin Linares, C.A. Falasca, C.A. Sartorio, G.C. Soto, R.J. gastrin duodenum acidification duodenum ulcer enterogastrone etiology major clinical study stomach secretion therapy vagotomy vagus nerve Duodenum Gastric Juice Gastrins Human Hydrochloric Acid Hydrogen-Ion Concentration Middle Age Vagotomy Acid instillation into the duodenum inhibits basal and stimulated gastric secretion. In man vagotomy suppresses this secretory inhibition. It is postulated that such inhibition responds to a dual mechanism: an hormonal one (enterogastrone) and a nervous one (vagus nerve). This study showed that preoperative duodenal acidification of duodenal ulcer patients results in a decrease in basal gastric secretion and in gastrin levels. On the contrary, in patients submitted to vagal denervation-either through truncal division or highly selective vagotomy-duodenal acidification does not inhibit gastric secretion; however, a drop occurs in basal gastrin levels. An intact gastric vagal innervation therefore, seems necessary for the preservation of the sensitivity of the parietal cell to the effect of hormonal inhibitors, it being immaterial whether duodenal innervation is present or not, as that duodenal acidification provokes a significant fall in serum gastrin levels as determined by radioimmunoassay. This hormonal decrease produced by duodenal acidification can be explained by the inhibition of gastrin release from the antrum. Agreement is expressed with the opinion of other authors that highly selective vagotomy does not appear to carry any advantage over truncal section of the vagus nerves from the standpoint of the inhibitory mechanism of gastric secretion from the duodenum. © 1977. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00396060_v81_n4_p392_Linares
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic gastrin
duodenum acidification
duodenum ulcer
enterogastrone
etiology
major clinical study
stomach secretion
therapy
vagotomy
vagus nerve
Duodenum
Gastric Juice
Gastrins
Human
Hydrochloric Acid
Hydrogen-Ion Concentration
Middle Age
Vagotomy
spellingShingle gastrin
duodenum acidification
duodenum ulcer
enterogastrone
etiology
major clinical study
stomach secretion
therapy
vagotomy
vagus nerve
Duodenum
Gastric Juice
Gastrins
Human
Hydrochloric Acid
Hydrogen-Ion Concentration
Middle Age
Vagotomy
Linares, C.A.
Falasca, C.A.
Sartorio, G.C.
Soto, R.J.
Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin
topic_facet gastrin
duodenum acidification
duodenum ulcer
enterogastrone
etiology
major clinical study
stomach secretion
therapy
vagotomy
vagus nerve
Duodenum
Gastric Juice
Gastrins
Human
Hydrochloric Acid
Hydrogen-Ion Concentration
Middle Age
Vagotomy
description Acid instillation into the duodenum inhibits basal and stimulated gastric secretion. In man vagotomy suppresses this secretory inhibition. It is postulated that such inhibition responds to a dual mechanism: an hormonal one (enterogastrone) and a nervous one (vagus nerve). This study showed that preoperative duodenal acidification of duodenal ulcer patients results in a decrease in basal gastric secretion and in gastrin levels. On the contrary, in patients submitted to vagal denervation-either through truncal division or highly selective vagotomy-duodenal acidification does not inhibit gastric secretion; however, a drop occurs in basal gastrin levels. An intact gastric vagal innervation therefore, seems necessary for the preservation of the sensitivity of the parietal cell to the effect of hormonal inhibitors, it being immaterial whether duodenal innervation is present or not, as that duodenal acidification provokes a significant fall in serum gastrin levels as determined by radioimmunoassay. This hormonal decrease produced by duodenal acidification can be explained by the inhibition of gastrin release from the antrum. Agreement is expressed with the opinion of other authors that highly selective vagotomy does not appear to carry any advantage over truncal section of the vagus nerves from the standpoint of the inhibitory mechanism of gastric secretion from the duodenum. © 1977.
format JOUR
author Linares, C.A.
Falasca, C.A.
Sartorio, G.C.
Soto, R.J.
author_facet Linares, C.A.
Falasca, C.A.
Sartorio, G.C.
Soto, R.J.
author_sort Linares, C.A.
title Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin
title_short Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin
title_full Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin
title_fullStr Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin
title_full_unstemmed Effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin
title_sort effect of intraduodenal acid on the pre- and postvagotomy basal gastric secretion and gastrin
url http://hdl.handle.net/20.500.12110/paper_00396060_v81_n4_p392_Linares
work_keys_str_mv AT linaresca effectofintraduodenalacidonthepreandpostvagotomybasalgastricsecretionandgastrin
AT falascaca effectofintraduodenalacidonthepreandpostvagotomybasalgastricsecretionandgastrin
AT sartoriogc effectofintraduodenalacidonthepreandpostvagotomybasalgastricsecretionandgastrin
AT sotorj effectofintraduodenalacidonthepreandpostvagotomybasalgastricsecretionandgastrin
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