Synthesis and antifungal activity of C-21 steroids with an aromatic D ring

Six analogues of salpichrolides with a simplified side chain (6-11) were synthesized using a new methodology to obtain steroids with an aromatic D-ring. The key step was the elimination of HBr in a vicinal dibromo D-homosteroid by treatment with 1,4-diazabicyclo[2.2.2]octane (DABCO). All new compoun...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sonego, J.M., Cirigliano, A.M., Cabrera, G.M., Burton, G., Veleiro, A.S.
Formato:	JOUR
Materias:	Antifungal activity Aromatic D-ring DABCO Salpichrolides steroid antifungal activity aromatic D ring article drug structure drug synthesis Fusarium Fusarium solani Fusarium virguliforme nonhuman Antifungal Agents Ergosterol Molecular Structure Steroids
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0039128X_v78_n7_p644_Sonego
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_0039128X_v78_n7_p644_Sonego
record_format	dspace
spelling	todo:paper_0039128X_v78_n7_p644_Sonego2023-10-03T14:49:32Z Synthesis and antifungal activity of C-21 steroids with an aromatic D ring Sonego, J.M. Cirigliano, A.M. Cabrera, G.M. Burton, G. Veleiro, A.S. Antifungal activity Aromatic D-ring DABCO Salpichrolides steroid antifungal activity aromatic D ring article drug structure drug synthesis Fusarium Fusarium solani Fusarium virguliforme nonhuman Antifungal Agents Ergosterol Fusarium Molecular Structure Steroids Fusarium solani Fusarium virguliforme Six analogues of salpichrolides with a simplified side chain (6-11) were synthesized using a new methodology to obtain steroids with an aromatic D-ring. The key step was the elimination of HBr in a vicinal dibromo D-homosteroid by treatment with 1,4-diazabicyclo[2.2.2]octane (DABCO). All new compounds were completely characterized by 2D NMR techniques and tested on two fungal pathogenic species, Fusarium virguliforme and Fusarium solani. © 2013 Elsevier Ltd. All rights reserved. Fil:Sonego, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cirigliano, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cabrera, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0039128X_v78_n7_p644_Sonego
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antifungal activity Aromatic D-ring DABCO Salpichrolides steroid antifungal activity aromatic D ring article drug structure drug synthesis Fusarium Fusarium solani Fusarium virguliforme nonhuman Antifungal Agents Ergosterol Fusarium Molecular Structure Steroids Fusarium solani Fusarium virguliforme
spellingShingle	Antifungal activity Aromatic D-ring DABCO Salpichrolides steroid antifungal activity aromatic D ring article drug structure drug synthesis Fusarium Fusarium solani Fusarium virguliforme nonhuman Antifungal Agents Ergosterol Fusarium Molecular Structure Steroids Fusarium solani Fusarium virguliforme Sonego, J.M. Cirigliano, A.M. Cabrera, G.M. Burton, G. Veleiro, A.S. Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
topic_facet	Antifungal activity Aromatic D-ring DABCO Salpichrolides steroid antifungal activity aromatic D ring article drug structure drug synthesis Fusarium Fusarium solani Fusarium virguliforme nonhuman Antifungal Agents Ergosterol Fusarium Molecular Structure Steroids Fusarium solani Fusarium virguliforme
description	Six analogues of salpichrolides with a simplified side chain (6-11) were synthesized using a new methodology to obtain steroids with an aromatic D-ring. The key step was the elimination of HBr in a vicinal dibromo D-homosteroid by treatment with 1,4-diazabicyclo[2.2.2]octane (DABCO). All new compounds were completely characterized by 2D NMR techniques and tested on two fungal pathogenic species, Fusarium virguliforme and Fusarium solani. © 2013 Elsevier Ltd. All rights reserved.
format	JOUR
author	Sonego, J.M. Cirigliano, A.M. Cabrera, G.M. Burton, G. Veleiro, A.S.
author_facet	Sonego, J.M. Cirigliano, A.M. Cabrera, G.M. Burton, G. Veleiro, A.S.
author_sort	Sonego, J.M.
title	Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
title_short	Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
title_full	Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
title_fullStr	Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
title_full_unstemmed	Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
title_sort	synthesis and antifungal activity of c-21 steroids with an aromatic d ring
url	http://hdl.handle.net/20.500.12110/paper_0039128X_v78_n7_p644_Sonego
work_keys_str_mv	AT sonegojm synthesisandantifungalactivityofc21steroidswithanaromaticdring AT ciriglianoam synthesisandantifungalactivityofc21steroidswithanaromaticdring AT cabreragm synthesisandantifungalactivityofc21steroidswithanaromaticdring AT burtong synthesisandantifungalactivityofc21steroidswithanaromaticdring AT veleiroas synthesisandantifungalactivityofc21steroidswithanaromaticdring
_version_	1782026933588983808

Synthesis and antifungal activity of C-21 steroids with an aromatic D ring

Ejemplares similares