Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone

18-Hydroxy-6,19-oxidoprogesterone and 18-hydroxy-11,19- oxidoprogesterone were synthesized from readily available materials. The functionalization of C-18 was accomplished with phenyliodosodiacetate/iodine, whereas that of C-19 was carried out with the mercuric oxide/iodine system, both under irradi...

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Autores principales:	Benedetti Doctorovich, M.O.V., Ghini, A.A., Burton, G.
Formato:	JOUR
Materias:	18-hydroxypregnanes oxido-bridged pregnanes 18 hydroxy 11,19 oxidoprogesterone 18 hydroxy 6,19 oxidoprogesterone progesterone derivative unclassified drug article carbon nuclear magnetic resonance drug synthesis irradiation proton nuclear magnetic resonance steroidogenesis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0039128X_v61_n6_p345_BenedettiDoctorovich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_0039128X_v61_n6_p345_BenedettiDoctorovich
record_format	dspace
spelling	todo:paper_0039128X_v61_n6_p345_BenedettiDoctorovich2023-10-03T14:49:24Z Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone Benedetti Doctorovich, M.O.V. Ghini, A.A. Burton, G. 18-hydroxypregnanes oxido-bridged pregnanes 18 hydroxy 11,19 oxidoprogesterone 18 hydroxy 6,19 oxidoprogesterone progesterone derivative unclassified drug article carbon nuclear magnetic resonance drug synthesis irradiation proton nuclear magnetic resonance steroidogenesis 18-Hydroxy-6,19-oxidoprogesterone and 18-hydroxy-11,19- oxidoprogesterone were synthesized from readily available materials. The functionalization of C-18 was accomplished with phenyliodosodiacetate/iodine, whereas that of C-19 was carried out with the mercuric oxide/iodine system, both under irradiation with visible light. For 18-hydroxy-11,19-oxidoprogesterone, C-19 was functionalized before C-18, whereas the reverse order had to be used for the 6,19-oxido derivative. Fil:Benedetti Doctorovich, M.O.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ghini, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0039128X_v61_n6_p345_BenedettiDoctorovich
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	18-hydroxypregnanes oxido-bridged pregnanes 18 hydroxy 11,19 oxidoprogesterone 18 hydroxy 6,19 oxidoprogesterone progesterone derivative unclassified drug article carbon nuclear magnetic resonance drug synthesis irradiation proton nuclear magnetic resonance steroidogenesis
spellingShingle	18-hydroxypregnanes oxido-bridged pregnanes 18 hydroxy 11,19 oxidoprogesterone 18 hydroxy 6,19 oxidoprogesterone progesterone derivative unclassified drug article carbon nuclear magnetic resonance drug synthesis irradiation proton nuclear magnetic resonance steroidogenesis Benedetti Doctorovich, M.O.V. Ghini, A.A. Burton, G. Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone
topic_facet	18-hydroxypregnanes oxido-bridged pregnanes 18 hydroxy 11,19 oxidoprogesterone 18 hydroxy 6,19 oxidoprogesterone progesterone derivative unclassified drug article carbon nuclear magnetic resonance drug synthesis irradiation proton nuclear magnetic resonance steroidogenesis
description	18-Hydroxy-6,19-oxidoprogesterone and 18-hydroxy-11,19- oxidoprogesterone were synthesized from readily available materials. The functionalization of C-18 was accomplished with phenyliodosodiacetate/iodine, whereas that of C-19 was carried out with the mercuric oxide/iodine system, both under irradiation with visible light. For 18-hydroxy-11,19-oxidoprogesterone, C-19 was functionalized before C-18, whereas the reverse order had to be used for the 6,19-oxido derivative.
format	JOUR
author	Benedetti Doctorovich, M.O.V. Ghini, A.A. Burton, G.
author_facet	Benedetti Doctorovich, M.O.V. Ghini, A.A. Burton, G.
author_sort	Benedetti Doctorovich, M.O.V.
title	Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone
title_short	Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone
title_full	Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone
title_fullStr	Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone
title_full_unstemmed	Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone
title_sort	synthesis of oxido-bridged analogs of 18-hydroxyprogesterone
url	http://hdl.handle.net/20.500.12110/paper_0039128X_v61_n6_p345_BenedettiDoctorovich
work_keys_str_mv	AT benedettidoctorovichmov synthesisofoxidobridgedanalogsof18hydroxyprogesterone AT ghiniaa synthesisofoxidobridgedanalogsof18hydroxyprogesterone AT burtong synthesisofoxidobridgedanalogsof18hydroxyprogesterone
_version_	1782029835702370304

Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone

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