Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives
In this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis. Fifteen acetyl and ester derivatives, twelve of them new, were obtained through an enzymatic strategy in a fully regioselective way and in ve...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0039128X_v140_n_p45_Chanquia |
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todo:paper_0039128X_v140_n_p45_Chanquia2023-10-03T14:49:19Z Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives Chanquia, S.N. Ripani, E. Baldessari, A. García Liñares, G. Bile acid Biocatalysis Hyodeoxycholic acid Lipases acetic acid derivative alcohol bile acid ester derivative hyodeoxycholic acid solvent triacylglycerol lipase Article biocatalysis regioselectivity synthesis In this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis. Fifteen acetyl and ester derivatives, twelve of them new, were obtained through an enzymatic strategy in a fully regioselective way and in very good to excellent yield. In order to find the optimal reaction conditions, the influence of several parameters such as enzyme source, alcohol or acylating agent:substrate ratio, enzyme:substrate ratio, temperature and reaction solvent was considered. The excellent results obtained made this procedure very efficient, particularly considering the low amount of enzyme required. In addition, this methodology uses mild reaction conditions and has reduced environmental impact, making biocatalysis a suitable way to obtaining these bile acids derivatives. © 2018 Elsevier Inc. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0039128X_v140_n_p45_Chanquia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Bile acid Biocatalysis Hyodeoxycholic acid Lipases acetic acid derivative alcohol bile acid ester derivative hyodeoxycholic acid solvent triacylglycerol lipase Article biocatalysis regioselectivity synthesis |
| spellingShingle |
Bile acid Biocatalysis Hyodeoxycholic acid Lipases acetic acid derivative alcohol bile acid ester derivative hyodeoxycholic acid solvent triacylglycerol lipase Article biocatalysis regioselectivity synthesis Chanquia, S.N. Ripani, E. Baldessari, A. García Liñares, G. Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives |
| topic_facet |
Bile acid Biocatalysis Hyodeoxycholic acid Lipases acetic acid derivative alcohol bile acid ester derivative hyodeoxycholic acid solvent triacylglycerol lipase Article biocatalysis regioselectivity synthesis |
| description |
In this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis. Fifteen acetyl and ester derivatives, twelve of them new, were obtained through an enzymatic strategy in a fully regioselective way and in very good to excellent yield. In order to find the optimal reaction conditions, the influence of several parameters such as enzyme source, alcohol or acylating agent:substrate ratio, enzyme:substrate ratio, temperature and reaction solvent was considered. The excellent results obtained made this procedure very efficient, particularly considering the low amount of enzyme required. In addition, this methodology uses mild reaction conditions and has reduced environmental impact, making biocatalysis a suitable way to obtaining these bile acids derivatives. © 2018 Elsevier Inc. |
| format |
JOUR |
| author |
Chanquia, S.N. Ripani, E. Baldessari, A. García Liñares, G. |
| author_facet |
Chanquia, S.N. Ripani, E. Baldessari, A. García Liñares, G. |
| author_sort |
Chanquia, S.N. |
| title |
Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives |
| title_short |
Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives |
| title_full |
Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives |
| title_fullStr |
Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives |
| title_full_unstemmed |
Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives |
| title_sort |
bile acids: lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives |
| url |
http://hdl.handle.net/20.500.12110/paper_0039128X_v140_n_p45_Chanquia |
| work_keys_str_mv |
AT chanquiasn bileacidslipasecatalyzedsynthesisofnewhyodeoxycholicacidderivatives AT ripanie bileacidslipasecatalyzedsynthesisofnewhyodeoxycholicacidderivatives AT baldessaria bileacidslipasecatalyzedsynthesisofnewhyodeoxycholicacidderivatives AT garcialinaresg bileacidslipasecatalyzedsynthesisofnewhyodeoxycholicacidderivatives |
| _version_ |
1807316130093596672 |