New cholic acid derivatives: Biocatalytic synthesis and molecular docking study

A series of cholic acid derivatives was synthesized by enzyme catalysis. Eleven acetyl and ester derivatives of cholic acid, eight of them new compounds, were obtained through regioselective lipase-catalyzed reactions in very good to excellent yield. The influence of various reaction parameters in t...

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Detalles Bibliográficos
Autores principales:	Zígolo, M.A., García Liñares, G., Baldessari, A.
Formato:	JOUR
Materias:	Cholic acid Lipase-catalyzed Molecular docking 3alpha,7alpha,12alpha triacetoxy 5beta cholanic acid alcohol butanol butyl 3alpha,7alpha,12alpha trihydroxy 5beta cholanate cholic acid cholic acid derivative dodecyl 3alpha,7alpha,12alpha trihydroxy 5beta cholanate ethyl 3alpha acetoxy 7alpha,12alpha dihydroxy 5beta cholanate ethyl 3alpha,7alpha,12alpha triacetoxy 5beta cholanate ethyl 3alpha,7alpha,12alpha trihydroxy 5beta cholanate ethyl 7alpha,12alpha diacetoxy 3alpha dihydroxy 5beta cholanate hexadecanol hexadecyl 3alpha,7alpha,12alpha trihydroxy 5beta cholanate lauryl alcohol myristyl alcohol octadecanol octadecyl 3alpha,7alpha,12alpha trihydroxy 5beta cholanate propanol solvent tetradecyl 3alpha,7alpha,12alpha trihydroxy 5beta cholanate triacylglycerol lipase unclassified drug Lipozyme acetylation alcoholysis Article biocatalysis esterification molecular docking synthesis temperature Cholic Acids Lipase
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0039128X_v107_n_p10_Zigolo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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