Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor
The mechanism of action of a specific γ-aminobutyric acid B receptor agonist, γ-p-chlorophenyl-γ-aminobutyric acid or baclofen, in its inhibitory action on prolactin release, was studied. Dose-response studies of the effect of baclofen on prolactin (PRL) secretion were performed in stressed male rat...
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todo:paper_00379727_v197_n3_p337_LuxLantos2023-10-03T14:48:13Z Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor Lux-Lantos, V. Somoza, G. Rey, E. Libertun, C. baclofen haloperidol metirosine prolactin releasing factor serotonin sulpiride animal experiment article controlled study female intraperitoneal drug administration male priority journal prolactin release rat alpha-Methyltyrosine Animal Baclofen Dose-Response Relationship, Drug Female Haloperidol Male Methyltyrosines Prolactin Prolactin-Releasing Hormone Rats Rats, Inbred Strains Serotonin Sulpiride Support, Non-U.S. Gov't The mechanism of action of a specific γ-aminobutyric acid B receptor agonist, γ-p-chlorophenyl-γ-aminobutyric acid or baclofen, in its inhibitory action on prolactin release, was studied. Dose-response studies of the effect of baclofen on prolactin (PRL) secretion were performed in stressed male rats. Furthermore, the action of the drug was evaluated in (i) rats treated with haloperidol or α-methyl-p-tyrosine, (ii) stressed or suckled rats pretreated with sulpiride, and (iii) animals treated with serotonin, alone, or with α-methyl-p-tyrosine. Baclofen showed a clear dose-dependent inhibition of prolactin secretion in males under stress. The drug was unable to inhibit the prolactin release induced by haloperidol or α-methyl-p-tyrosine, although it reduced the PRL secretion induced by serotonin. It also inhibited PRL release in sulpiride-pretreated stressed or suckled rats. These results suggest that the dose-dependent effect of baclofen on PRL secretion is the consequence of an inhibition exerted on the prolactin-releasing factor component of the neuroendocrine responses evoked by stress or suckling, possibly acting at the serotonergic system. © 1991, SAGE Publications. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00379727_v197_n3_p337_LuxLantos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
baclofen haloperidol metirosine prolactin releasing factor serotonin sulpiride animal experiment article controlled study female intraperitoneal drug administration male priority journal prolactin release rat alpha-Methyltyrosine Animal Baclofen Dose-Response Relationship, Drug Female Haloperidol Male Methyltyrosines Prolactin Prolactin-Releasing Hormone Rats Rats, Inbred Strains Serotonin Sulpiride Support, Non-U.S. Gov't |
| spellingShingle |
baclofen haloperidol metirosine prolactin releasing factor serotonin sulpiride animal experiment article controlled study female intraperitoneal drug administration male priority journal prolactin release rat alpha-Methyltyrosine Animal Baclofen Dose-Response Relationship, Drug Female Haloperidol Male Methyltyrosines Prolactin Prolactin-Releasing Hormone Rats Rats, Inbred Strains Serotonin Sulpiride Support, Non-U.S. Gov't Lux-Lantos, V. Somoza, G. Rey, E. Libertun, C. Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor |
| topic_facet |
baclofen haloperidol metirosine prolactin releasing factor serotonin sulpiride animal experiment article controlled study female intraperitoneal drug administration male priority journal prolactin release rat alpha-Methyltyrosine Animal Baclofen Dose-Response Relationship, Drug Female Haloperidol Male Methyltyrosines Prolactin Prolactin-Releasing Hormone Rats Rats, Inbred Strains Serotonin Sulpiride Support, Non-U.S. Gov't |
| description |
The mechanism of action of a specific γ-aminobutyric acid B receptor agonist, γ-p-chlorophenyl-γ-aminobutyric acid or baclofen, in its inhibitory action on prolactin release, was studied. Dose-response studies of the effect of baclofen on prolactin (PRL) secretion were performed in stressed male rats. Furthermore, the action of the drug was evaluated in (i) rats treated with haloperidol or α-methyl-p-tyrosine, (ii) stressed or suckled rats pretreated with sulpiride, and (iii) animals treated with serotonin, alone, or with α-methyl-p-tyrosine. Baclofen showed a clear dose-dependent inhibition of prolactin secretion in males under stress. The drug was unable to inhibit the prolactin release induced by haloperidol or α-methyl-p-tyrosine, although it reduced the PRL secretion induced by serotonin. It also inhibited PRL release in sulpiride-pretreated stressed or suckled rats. These results suggest that the dose-dependent effect of baclofen on PRL secretion is the consequence of an inhibition exerted on the prolactin-releasing factor component of the neuroendocrine responses evoked by stress or suckling, possibly acting at the serotonergic system. © 1991, SAGE Publications. All rights reserved. |
| format |
JOUR |
| author |
Lux-Lantos, V. Somoza, G. Rey, E. Libertun, C. |
| author_facet |
Lux-Lantos, V. Somoza, G. Rey, E. Libertun, C. |
| author_sort |
Lux-Lantos, V. |
| title |
Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor |
| title_short |
Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor |
| title_full |
Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor |
| title_fullStr |
Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor |
| title_full_unstemmed |
Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor |
| title_sort |
further evidence for the inhibitory action of baclofen on a prolactin-releasing factor |
| url |
http://hdl.handle.net/20.500.12110/paper_00379727_v197_n3_p337_LuxLantos |
| work_keys_str_mv |
AT luxlantosv furtherevidencefortheinhibitoryactionofbaclofenonaprolactinreleasingfactor AT somozag furtherevidencefortheinhibitoryactionofbaclofenonaprolactinreleasingfactor AT reye furtherevidencefortheinhibitoryactionofbaclofenonaprolactinreleasingfactor AT libertunc furtherevidencefortheinhibitoryactionofbaclofenonaprolactinreleasingfactor |
| _version_ |
1807324001061568512 |