Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin
The presence and the importance of a preovulatory prolactin (PRL) peak was determined in four, natural or artificially induced, ovulatory models related to lactation in the rat. Gonadotrophin peaks were determined in the afternoon preceding ovulation in four models: postpartum ovulation (PPO), ovula...
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todo:paper_00379727_v188_n3_p301_Lux2023-10-03T14:48:13Z Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin Lux, V.A.R. Ramírez, M.I. Libertun, C. bromocriptine follitropin luteinizing hormone pergolide prolactin prolactin animal article biological model blood drug effect female lactation ovulation ovulation induction physiology pregnancy puerperium rat rat strain estrus cycle lactation nonhuman Animal Bromocriptine Female Follicle Stimulating Hormone Lactation Luteinizing Hormone Models, Biological Ovulation Ovulation Induction Pergolide Pregnancy Prolactin Puerperium Rats Rats, Inbred Strains Support, Non-U.S. Gov't The presence and the importance of a preovulatory prolactin (PRL) peak was determined in four, natural or artificially induced, ovulatory models related to lactation in the rat. Gonadotrophin peaks were determined in the afternoon preceding ovulation in four models: postpartum ovulation (PPO), ovulation after the lactational period (AL) (natural models), ovulation after litter removal at midlactation (ML), and ovulation in lactating rats (LR) (artificially induced models). In PPO, AL, and ML rats a preovulatory PRL surge was detected, showing that its presence is a common characteristic of ovulation in the rat. Bromocriptine inhibition of PRL levels in PPO and AL rats did not modify the percentage of rats which ovulated. In contrast, this treatment was able to significantly increase ovulation percentage in ML rats. Moreover, in LR rats strong dopaminergic inhibition of PRL levels, induced by pergolide, was necessary for ovulation to take place, but if pergolide-treated rats were injected with ovine PRL ovulation was completely inhibited. These data suggest that while a PRL surge seems to be always present in natural ovulatory models, it is not essential for ovulation to take place. On the other hand, in artificially induced ovulatory models, suppression of prolactinemia is able to induce ovulation or to increase the percentage of rats which ovulated. This effect of PRL on ovulation may be direct or indirect. © 1988, SAGE Publications. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00379727_v188_n3_p301_Lux |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
bromocriptine follitropin luteinizing hormone pergolide prolactin prolactin animal article biological model blood drug effect female lactation ovulation ovulation induction physiology pregnancy puerperium rat rat strain estrus cycle lactation nonhuman Animal Bromocriptine Female Follicle Stimulating Hormone Lactation Luteinizing Hormone Models, Biological Ovulation Ovulation Induction Pergolide Pregnancy Prolactin Puerperium Rats Rats, Inbred Strains Support, Non-U.S. Gov't |
| spellingShingle |
bromocriptine follitropin luteinizing hormone pergolide prolactin prolactin animal article biological model blood drug effect female lactation ovulation ovulation induction physiology pregnancy puerperium rat rat strain estrus cycle lactation nonhuman Animal Bromocriptine Female Follicle Stimulating Hormone Lactation Luteinizing Hormone Models, Biological Ovulation Ovulation Induction Pergolide Pregnancy Prolactin Puerperium Rats Rats, Inbred Strains Support, Non-U.S. Gov't Lux, V.A.R. Ramírez, M.I. Libertun, C. Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin |
| topic_facet |
bromocriptine follitropin luteinizing hormone pergolide prolactin prolactin animal article biological model blood drug effect female lactation ovulation ovulation induction physiology pregnancy puerperium rat rat strain estrus cycle lactation nonhuman Animal Bromocriptine Female Follicle Stimulating Hormone Lactation Luteinizing Hormone Models, Biological Ovulation Ovulation Induction Pergolide Pregnancy Prolactin Puerperium Rats Rats, Inbred Strains Support, Non-U.S. Gov't |
| description |
The presence and the importance of a preovulatory prolactin (PRL) peak was determined in four, natural or artificially induced, ovulatory models related to lactation in the rat. Gonadotrophin peaks were determined in the afternoon preceding ovulation in four models: postpartum ovulation (PPO), ovulation after the lactational period (AL) (natural models), ovulation after litter removal at midlactation (ML), and ovulation in lactating rats (LR) (artificially induced models). In PPO, AL, and ML rats a preovulatory PRL surge was detected, showing that its presence is a common characteristic of ovulation in the rat. Bromocriptine inhibition of PRL levels in PPO and AL rats did not modify the percentage of rats which ovulated. In contrast, this treatment was able to significantly increase ovulation percentage in ML rats. Moreover, in LR rats strong dopaminergic inhibition of PRL levels, induced by pergolide, was necessary for ovulation to take place, but if pergolide-treated rats were injected with ovine PRL ovulation was completely inhibited. These data suggest that while a PRL surge seems to be always present in natural ovulatory models, it is not essential for ovulation to take place. On the other hand, in artificially induced ovulatory models, suppression of prolactinemia is able to induce ovulation or to increase the percentage of rats which ovulated. This effect of PRL on ovulation may be direct or indirect. © 1988, SAGE Publications. All rights reserved. |
| format |
JOUR |
| author |
Lux, V.A.R. Ramírez, M.I. Libertun, C. |
| author_facet |
Lux, V.A.R. Ramírez, M.I. Libertun, C. |
| author_sort |
Lux, V.A.R. |
| title |
Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin |
| title_short |
Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin |
| title_full |
Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin |
| title_fullStr |
Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin |
| title_full_unstemmed |
Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin |
| title_sort |
natural and artificially induced ovulatory models related to lactation in the rat: role of prolactin |
| url |
http://hdl.handle.net/20.500.12110/paper_00379727_v188_n3_p301_Lux |
| work_keys_str_mv |
AT luxvar naturalandartificiallyinducedovulatorymodelsrelatedtolactationintheratroleofprolactin AT ramirezmi naturalandartificiallyinducedovulatorymodelsrelatedtolactationintheratroleofprolactin AT libertunc naturalandartificiallyinducedovulatorymodelsrelatedtolactationintheratroleofprolactin |
| _version_ |
1807321978839760896 |