Inhibition of Prolactin Secretion by GABA in Female and Male Rats

The effect of GABA on prolactin secretion from the pituitary under physiological conditions in lactating female rats and in normal male rats was investigated. Prolactin was measured by RIA in blood samples taken from lactating mothers by means of an intrajugular silastic catheter, 10-15 days after d...

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Autores principales:	Libertun, C., Arakelian, M.C., Larrea, G.A., Foglia, V.G.
Formato:	JOUR
Materias:	4 aminobutyric acid aminooxyacetic acid estrogen ether animal experiment endocrine system female intracerebroventricular drug administration intraperitoneal drug administration lactation male prolactin blood level prolactin release radioimmunoassay rat Aminooxyacetic Acid Animal Comparative Study Female gamma-Aminobutyric Acid Injections, Intraperitoneal Injections, Intraventricular Lactation Male Pituitary Gland Pregnancy Prolactin Rats Stress
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00379727_v161_n1_p28_Libertun
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00379727_v161_n1_p28_Libertun
record_format	dspace
spelling	todo:paper_00379727_v161_n1_p28_Libertun2023-10-03T14:48:12Z Inhibition of Prolactin Secretion by GABA in Female and Male Rats Libertun, C. Arakelian, M.C. Larrea, G.A. Foglia, V.G. 4 aminobutyric acid aminooxyacetic acid estrogen ether animal experiment endocrine system female intracerebroventricular drug administration intraperitoneal drug administration lactation male prolactin blood level prolactin release radioimmunoassay rat Aminooxyacetic Acid Animal Comparative Study Female gamma-Aminobutyric Acid Injections, Intraperitoneal Injections, Intraventricular Lactation Male Pituitary Gland Pregnancy Prolactin Rats Stress The effect of GABA on prolactin secretion from the pituitary under physiological conditions in lactating female rats and in normal male rats was investigated. Prolactin was measured by RIA in blood samples taken from lactating mothers by means of an intrajugular silastic catheter, 10-15 days after delivery. GABA in doses of 825 μg, but not 150 μg, microinjected into the third ventricle partially suppressed the serum prolactin rise due to suckling. Aminooxyacetic acid (AOAA), 30 mg/kg ip, which has been reported to produce a sharp increase in GABA content in the CNS, significantly suppressed the prolactin increment during the suckling period. By contrast, in non suckled mothers, GABA or AOAA was ineffective in altering serum prolactin. In normal male rats, GABA and AOAA were able to partially suppress prolactin release due to ether stress. These results clearly show that increments in GABA content in the brain after microinjection of exogenous GABA or following suppression of enzymatic inactivation of the endogenous amino acid were able to inhibit prolactin release under physiological conditions. © 1979, SAGE Publications. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00379727_v161_n1_p28_Libertun
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	4 aminobutyric acid aminooxyacetic acid estrogen ether animal experiment endocrine system female intracerebroventricular drug administration intraperitoneal drug administration lactation male prolactin blood level prolactin release radioimmunoassay rat Aminooxyacetic Acid Animal Comparative Study Female gamma-Aminobutyric Acid Injections, Intraperitoneal Injections, Intraventricular Lactation Male Pituitary Gland Pregnancy Prolactin Rats Stress
spellingShingle	4 aminobutyric acid aminooxyacetic acid estrogen ether animal experiment endocrine system female intracerebroventricular drug administration intraperitoneal drug administration lactation male prolactin blood level prolactin release radioimmunoassay rat Aminooxyacetic Acid Animal Comparative Study Female gamma-Aminobutyric Acid Injections, Intraperitoneal Injections, Intraventricular Lactation Male Pituitary Gland Pregnancy Prolactin Rats Stress Libertun, C. Arakelian, M.C. Larrea, G.A. Foglia, V.G. Inhibition of Prolactin Secretion by GABA in Female and Male Rats
topic_facet	4 aminobutyric acid aminooxyacetic acid estrogen ether animal experiment endocrine system female intracerebroventricular drug administration intraperitoneal drug administration lactation male prolactin blood level prolactin release radioimmunoassay rat Aminooxyacetic Acid Animal Comparative Study Female gamma-Aminobutyric Acid Injections, Intraperitoneal Injections, Intraventricular Lactation Male Pituitary Gland Pregnancy Prolactin Rats Stress
description	The effect of GABA on prolactin secretion from the pituitary under physiological conditions in lactating female rats and in normal male rats was investigated. Prolactin was measured by RIA in blood samples taken from lactating mothers by means of an intrajugular silastic catheter, 10-15 days after delivery. GABA in doses of 825 μg, but not 150 μg, microinjected into the third ventricle partially suppressed the serum prolactin rise due to suckling. Aminooxyacetic acid (AOAA), 30 mg/kg ip, which has been reported to produce a sharp increase in GABA content in the CNS, significantly suppressed the prolactin increment during the suckling period. By contrast, in non suckled mothers, GABA or AOAA was ineffective in altering serum prolactin. In normal male rats, GABA and AOAA were able to partially suppress prolactin release due to ether stress. These results clearly show that increments in GABA content in the brain after microinjection of exogenous GABA or following suppression of enzymatic inactivation of the endogenous amino acid were able to inhibit prolactin release under physiological conditions. © 1979, SAGE Publications. All rights reserved.
format	JOUR
author	Libertun, C. Arakelian, M.C. Larrea, G.A. Foglia, V.G.
author_facet	Libertun, C. Arakelian, M.C. Larrea, G.A. Foglia, V.G.
author_sort	Libertun, C.
title	Inhibition of Prolactin Secretion by GABA in Female and Male Rats
title_short	Inhibition of Prolactin Secretion by GABA in Female and Male Rats
title_full	Inhibition of Prolactin Secretion by GABA in Female and Male Rats
title_fullStr	Inhibition of Prolactin Secretion by GABA in Female and Male Rats
title_full_unstemmed	Inhibition of Prolactin Secretion by GABA in Female and Male Rats
title_sort	inhibition of prolactin secretion by gaba in female and male rats
url	http://hdl.handle.net/20.500.12110/paper_00379727_v161_n1_p28_Libertun
work_keys_str_mv	AT libertunc inhibitionofprolactinsecretionbygabainfemaleandmalerats AT arakelianmc inhibitionofprolactinsecretionbygabainfemaleandmalerats AT larreaga inhibitionofprolactinsecretionbygabainfemaleandmalerats AT fogliavg inhibitionofprolactinsecretionbygabainfemaleandmalerats
_version_	1807322637846708224

Inhibition of Prolactin Secretion by GABA in Female and Male Rats

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