A doppler effect in embryonic pattern formation
During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, w...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00368075_v345_n6193_p222_Soroldoni |
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todo:paper_00368075_v345_n6193_p222_Soroldoni2023-10-03T14:47:56Z A doppler effect in embryonic pattern formation Soroldoni, D. Jörg, D.J. Morelli, L.G. Richmond, D.L. Schindelin, J. Jul̈icher, F. Oates, A.C. cyprinid Doppler effect embryo embryonic development genetic variation animal experiment article biological rhythm Doppler flowmetry embryo development embryo pattern formation embryo segmentation embryonic structures gene expression genetic analysis germ layer kinematics nonhuman oscillation physical parameters priority journal spike wave steady state tissue level transgenics zebra fish animal animal embryo genetics morphogenesis periodicity physiology prenatal development Animals Body Patterning Doppler Effect Embryo, Nonmammalian Periodicity Zebrafish During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00368075_v345_n6193_p222_Soroldoni |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
cyprinid Doppler effect embryo embryonic development genetic variation animal experiment article biological rhythm Doppler flowmetry embryo development embryo pattern formation embryo segmentation embryonic structures gene expression genetic analysis germ layer kinematics nonhuman oscillation physical parameters priority journal spike wave steady state tissue level transgenics zebra fish animal animal embryo genetics morphogenesis periodicity physiology prenatal development Animals Body Patterning Doppler Effect Embryo, Nonmammalian Periodicity Zebrafish |
| spellingShingle |
cyprinid Doppler effect embryo embryonic development genetic variation animal experiment article biological rhythm Doppler flowmetry embryo development embryo pattern formation embryo segmentation embryonic structures gene expression genetic analysis germ layer kinematics nonhuman oscillation physical parameters priority journal spike wave steady state tissue level transgenics zebra fish animal animal embryo genetics morphogenesis periodicity physiology prenatal development Animals Body Patterning Doppler Effect Embryo, Nonmammalian Periodicity Zebrafish Soroldoni, D. Jörg, D.J. Morelli, L.G. Richmond, D.L. Schindelin, J. Jul̈icher, F. Oates, A.C. A doppler effect in embryonic pattern formation |
| topic_facet |
cyprinid Doppler effect embryo embryonic development genetic variation animal experiment article biological rhythm Doppler flowmetry embryo development embryo pattern formation embryo segmentation embryonic structures gene expression genetic analysis germ layer kinematics nonhuman oscillation physical parameters priority journal spike wave steady state tissue level transgenics zebra fish animal animal embryo genetics morphogenesis periodicity physiology prenatal development Animals Body Patterning Doppler Effect Embryo, Nonmammalian Periodicity Zebrafish |
| description |
During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening. |
| format |
JOUR |
| author |
Soroldoni, D. Jörg, D.J. Morelli, L.G. Richmond, D.L. Schindelin, J. Jul̈icher, F. Oates, A.C. |
| author_facet |
Soroldoni, D. Jörg, D.J. Morelli, L.G. Richmond, D.L. Schindelin, J. Jul̈icher, F. Oates, A.C. |
| author_sort |
Soroldoni, D. |
| title |
A doppler effect in embryonic pattern formation |
| title_short |
A doppler effect in embryonic pattern formation |
| title_full |
A doppler effect in embryonic pattern formation |
| title_fullStr |
A doppler effect in embryonic pattern formation |
| title_full_unstemmed |
A doppler effect in embryonic pattern formation |
| title_sort |
doppler effect in embryonic pattern formation |
| url |
http://hdl.handle.net/20.500.12110/paper_00368075_v345_n6193_p222_Soroldoni |
| work_keys_str_mv |
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