Agarofuran sesquiterpenes from Schaefferia argentinensis

Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and...

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Autores principales:	García, M.E., Motrich, R.D., Caputto, B.L., Sánchez, M., Palermo, J.A., Estévez-Braun, A., Ravelo, A.G., Nicotra, V.E.
Formato:	JOUR
Materias:	Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Schaefferia (angiosperm) antineoplastic agent dihydroagarofuran sesquiterpene antiproliferative activity article cell proliferation cell strain MCF 7 cell survival chemical structure chemistry drug effect human isolation and purification mass spectrometry methodology nuclear magnetic resonance spectroscopy phytochemistry plant tumor cell line Antineoplastic Agents, Phytogenic Cell Line, Tumor Cell Proliferation Cell Survival Humans Magnetic Resonance Spectroscopy Mass Spectrometry MCF-7 Cells Molecular Structure Plant Components, Aerial Sesquiterpenes
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00319422_v94_n_p260_Garcia
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00319422_v94_n_p260_Garcia2023-10-03T14:44:33Z Agarofuran sesquiterpenes from Schaefferia argentinensis García, M.E. Motrich, R.D. Caputto, B.L. Sánchez, M. Palermo, J.A. Estévez-Braun, A. Ravelo, A.G. Nicotra, V.E. Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Celastraceae Schaefferia (angiosperm) antineoplastic agent dihydroagarofuran sesquiterpene antiproliferative activity article Celastraceae cell proliferation cell strain MCF 7 cell survival chemical structure chemistry Dihydro-β-agarofuran sesquiterpene drug effect human isolation and purification mass spectrometry methodology nuclear magnetic resonance spectroscopy phytochemistry plant Schaefferia argentinensis tumor cell line Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Antineoplastic Agents, Phytogenic Celastraceae Cell Line, Tumor Cell Proliferation Cell Survival Humans Magnetic Resonance Spectroscopy Mass Spectrometry MCF-7 Cells Molecular Structure Plant Components, Aerial Sesquiterpenes Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines, but was found to be marginal. © 2013 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00319422_v94_n_p260_Garcia
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Celastraceae Schaefferia (angiosperm) antineoplastic agent dihydroagarofuran sesquiterpene antiproliferative activity article Celastraceae cell proliferation cell strain MCF 7 cell survival chemical structure chemistry Dihydro-β-agarofuran sesquiterpene drug effect human isolation and purification mass spectrometry methodology nuclear magnetic resonance spectroscopy phytochemistry plant Schaefferia argentinensis tumor cell line Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Antineoplastic Agents, Phytogenic Celastraceae Cell Line, Tumor Cell Proliferation Cell Survival Humans Magnetic Resonance Spectroscopy Mass Spectrometry MCF-7 Cells Molecular Structure Plant Components, Aerial Sesquiterpenes
spellingShingle	Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Celastraceae Schaefferia (angiosperm) antineoplastic agent dihydroagarofuran sesquiterpene antiproliferative activity article Celastraceae cell proliferation cell strain MCF 7 cell survival chemical structure chemistry Dihydro-β-agarofuran sesquiterpene drug effect human isolation and purification mass spectrometry methodology nuclear magnetic resonance spectroscopy phytochemistry plant Schaefferia argentinensis tumor cell line Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Antineoplastic Agents, Phytogenic Celastraceae Cell Line, Tumor Cell Proliferation Cell Survival Humans Magnetic Resonance Spectroscopy Mass Spectrometry MCF-7 Cells Molecular Structure Plant Components, Aerial Sesquiterpenes García, M.E. Motrich, R.D. Caputto, B.L. Sánchez, M. Palermo, J.A. Estévez-Braun, A. Ravelo, A.G. Nicotra, V.E. Agarofuran sesquiterpenes from Schaefferia argentinensis
topic_facet	Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Celastraceae Schaefferia (angiosperm) antineoplastic agent dihydroagarofuran sesquiterpene antiproliferative activity article Celastraceae cell proliferation cell strain MCF 7 cell survival chemical structure chemistry Dihydro-β-agarofuran sesquiterpene drug effect human isolation and purification mass spectrometry methodology nuclear magnetic resonance spectroscopy phytochemistry plant Schaefferia argentinensis tumor cell line Antiproliferative activity Celastraceae Dihydro-β-agarofuran sesquiterpene Phytochemistry Schaefferia argentinensis Antineoplastic Agents, Phytogenic Celastraceae Cell Line, Tumor Cell Proliferation Cell Survival Humans Magnetic Resonance Spectroscopy Mass Spectrometry MCF-7 Cells Molecular Structure Plant Components, Aerial Sesquiterpenes
description	Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines, but was found to be marginal. © 2013 Elsevier Ltd. All rights reserved.
format	JOUR
author	García, M.E. Motrich, R.D. Caputto, B.L. Sánchez, M. Palermo, J.A. Estévez-Braun, A. Ravelo, A.G. Nicotra, V.E.
author_facet	García, M.E. Motrich, R.D. Caputto, B.L. Sánchez, M. Palermo, J.A. Estévez-Braun, A. Ravelo, A.G. Nicotra, V.E.
author_sort	García, M.E.
title	Agarofuran sesquiterpenes from Schaefferia argentinensis
title_short	Agarofuran sesquiterpenes from Schaefferia argentinensis
title_full	Agarofuran sesquiterpenes from Schaefferia argentinensis
title_fullStr	Agarofuran sesquiterpenes from Schaefferia argentinensis
title_full_unstemmed	Agarofuran sesquiterpenes from Schaefferia argentinensis
title_sort	agarofuran sesquiterpenes from schaefferia argentinensis
url	http://hdl.handle.net/20.500.12110/paper_00319422_v94_n_p260_Garcia
work_keys_str_mv	AT garciame agarofuransesquiterpenesfromschaefferiaargentinensis AT motrichrd agarofuransesquiterpenesfromschaefferiaargentinensis AT caputtobl agarofuransesquiterpenesfromschaefferiaargentinensis AT sanchezm agarofuransesquiterpenesfromschaefferiaargentinensis AT palermoja agarofuransesquiterpenesfromschaefferiaargentinensis AT estevezbrauna agarofuransesquiterpenesfromschaefferiaargentinensis AT raveloag agarofuransesquiterpenesfromschaefferiaargentinensis AT nicotrave agarofuransesquiterpenesfromschaefferiaargentinensis
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Agarofuran sesquiterpenes from Schaefferia argentinensis

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