Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa

Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of wh...

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Autores principales:	De Almeida, M.T.R., Ríos-Luci, C., Padrón, J.M., Palermo, J.A.
Formato:	JOUR
Materias:	β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Idaea Vitaceae Vitis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00319422_v71_n14-15_p1741_DeAlmeida
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00319422_v71_n14-15_p1741_DeAlmeida
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spelling	todo:paper_00319422_v71_n14-15_p1741_DeAlmeida2023-10-03T14:44:31Z Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa De Almeida, M.T.R. Ríos-Luci, C. Padrón, J.M. Palermo, J.A. β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of which (4-7) were hitherto unknown. Additionally, from M. spinosa, two known celastroids, a known celastroid dimer (9), three pentacyclic triterpenoids (10-12) and six β-dihydroagarofuran sesquiterpenoid alkaloids (13-18) were identified. Compounds 4-7 were active against six solid tumor cell lines at micromolar concentrations. © 2010 Elsevier Ltd. All rights reserved. Fil:Palermo, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00319422_v71_n14-15_p1741_DeAlmeida
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis
spellingShingle	β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis De Almeida, M.T.R. Ríos-Luci, C. Padrón, J.M. Palermo, J.A. Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
topic_facet	β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis
description	Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of which (4-7) were hitherto unknown. Additionally, from M. spinosa, two known celastroids, a known celastroid dimer (9), three pentacyclic triterpenoids (10-12) and six β-dihydroagarofuran sesquiterpenoid alkaloids (13-18) were identified. Compounds 4-7 were active against six solid tumor cell lines at micromolar concentrations. © 2010 Elsevier Ltd. All rights reserved.
format	JOUR
author	De Almeida, M.T.R. Ríos-Luci, C. Padrón, J.M. Palermo, J.A.
author_facet	De Almeida, M.T.R. Ríos-Luci, C. Padrón, J.M. Palermo, J.A.
author_sort	De Almeida, M.T.R.
title	Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
title_short	Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
title_full	Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
title_fullStr	Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
title_full_unstemmed	Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
title_sort	antiproliferative terpenoids and alkaloids from the roots of maytenus vitis-idaea and maytenus spinosa
url	http://hdl.handle.net/20.500.12110/paper_00319422_v71_n14-15_p1741_DeAlmeida
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Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa

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