Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer
Boron neutron capture therapy (BNCT) is a treatment modality that combines different radiation qualities. Since the severity of biological damage following irradiation depends on the radiation type, a quantity different from absorbed dose is required to explain the effects observed in the clinical B...
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todo:paper_00319155_v62_n20_p7938_Gonzalez2023-10-03T14:43:24Z Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer González, S.J. Pozzi, E.C.C. Monti Hughes, A. Provenzano, L. Koivunoro, H. Carando, D.G. Thorp, S.I. Casal, M.R. Bortolussi, S. Trivillin, V.A. Garabalino, M.A. Curotto, P. Heber, E.M. Santa Cruz, G.A. Kankaanranta, L. Joensuu, H. Schwint, A.E. BNCT hamster cheek pouch in vivo model of oral cancer head and neck cancer NTCP photon iso-effective dose TCP Animals Boron Correlation methods Diseases Dosimetry Patient monitoring Patient treatment Photons Physiological models Radiation Radiation effects Radiotherapy Tissue Transmission control protocol Tumors BNCT Effective dose Head-and-neck cancer NTCP Oral cancer Neutron irradiation animal boron neutron capture therapy disease model hamster head and neck tumor human melanoma mouth tumor mucosa inflammation photon precancer radiometry squamous cell carcinoma Animals Boron Neutron Capture Therapy Carcinoma, Squamous Cell Cricetinae Disease Models, Animal Head and Neck Neoplasms Humans Melanoma Mouth Neoplasms Mucositis Photons Precancerous Conditions Radiometry Boron neutron capture therapy (BNCT) is a treatment modality that combines different radiation qualities. Since the severity of biological damage following irradiation depends on the radiation type, a quantity different from absorbed dose is required to explain the effects observed in the clinical BNCT in terms of outcome compared with conventional photon radiation therapy. A new approach for calculating photon iso-effective doses in BNCT was introduced previously. The present work extends this model to include information from dose-response assessments in animal models and humans. Parameters of the model were determined for tumour and precancerous tissue using dose-response curves obtained from BNCT and photon studies performed in the hamster cheek pouch in vivo models of oral cancer and/or pre-cancer, and from head and neck cancer radiotherapy data with photons. To this end, suitable expressions of the dose-limiting Normal Tissue Complication and Tumour Control Probabilities for the reference radiation and for the mixed field BNCT radiation were developed. Pearson's correlation coefficients and p-values showed that TCP and NTCP models agreed with experimental data (with r > 0.87 and p-values >0.57). The photon iso-effective dose model was applied retrospectively to evaluate the dosimetry in tumours and mucosa for head and neck cancer patients treated with BNCT in Finland. Photon iso-effective doses in tumour were lower than those obtained with the standard RBE-weighted model (between 10% to 45%). The results also suggested that the probabilities of tumour control derived from photon iso-effective doses are more adequate to explain the clinical responses than those obtained with the RBE-weighted values. The dosimetry in the mucosa revealed that the photon iso-effective doses were about 30% to 50% higher than the corresponding RBE-weighted values. While the RBE-weighted doses are unable to predict mucosa toxicity, predictions based on the proposed model are compatible with the observed clinical outcome. The extension of the photon iso-effective dose model has allowed, for the first time, the determination of the photon iso-effective dose for unacceptable complications in the dose-limiting normal tissue. Finally, the formalism developed in this work to compute photon-equivalent doses can be applied to other therapies that combine mixed radiation fields, such as hadron therapy. © 2017 Institute of Physics and Engineering in Medicine. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00319155_v62_n20_p7938_Gonzalez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
BNCT hamster cheek pouch in vivo model of oral cancer head and neck cancer NTCP photon iso-effective dose TCP Animals Boron Correlation methods Diseases Dosimetry Patient monitoring Patient treatment Photons Physiological models Radiation Radiation effects Radiotherapy Tissue Transmission control protocol Tumors BNCT Effective dose Head-and-neck cancer NTCP Oral cancer Neutron irradiation animal boron neutron capture therapy disease model hamster head and neck tumor human melanoma mouth tumor mucosa inflammation photon precancer radiometry squamous cell carcinoma Animals Boron Neutron Capture Therapy Carcinoma, Squamous Cell Cricetinae Disease Models, Animal Head and Neck Neoplasms Humans Melanoma Mouth Neoplasms Mucositis Photons Precancerous Conditions Radiometry |
| spellingShingle |
BNCT hamster cheek pouch in vivo model of oral cancer head and neck cancer NTCP photon iso-effective dose TCP Animals Boron Correlation methods Diseases Dosimetry Patient monitoring Patient treatment Photons Physiological models Radiation Radiation effects Radiotherapy Tissue Transmission control protocol Tumors BNCT Effective dose Head-and-neck cancer NTCP Oral cancer Neutron irradiation animal boron neutron capture therapy disease model hamster head and neck tumor human melanoma mouth tumor mucosa inflammation photon precancer radiometry squamous cell carcinoma Animals Boron Neutron Capture Therapy Carcinoma, Squamous Cell Cricetinae Disease Models, Animal Head and Neck Neoplasms Humans Melanoma Mouth Neoplasms Mucositis Photons Precancerous Conditions Radiometry González, S.J. Pozzi, E.C.C. Monti Hughes, A. Provenzano, L. Koivunoro, H. Carando, D.G. Thorp, S.I. Casal, M.R. Bortolussi, S. Trivillin, V.A. Garabalino, M.A. Curotto, P. Heber, E.M. Santa Cruz, G.A. Kankaanranta, L. Joensuu, H. Schwint, A.E. Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer |
| topic_facet |
BNCT hamster cheek pouch in vivo model of oral cancer head and neck cancer NTCP photon iso-effective dose TCP Animals Boron Correlation methods Diseases Dosimetry Patient monitoring Patient treatment Photons Physiological models Radiation Radiation effects Radiotherapy Tissue Transmission control protocol Tumors BNCT Effective dose Head-and-neck cancer NTCP Oral cancer Neutron irradiation animal boron neutron capture therapy disease model hamster head and neck tumor human melanoma mouth tumor mucosa inflammation photon precancer radiometry squamous cell carcinoma Animals Boron Neutron Capture Therapy Carcinoma, Squamous Cell Cricetinae Disease Models, Animal Head and Neck Neoplasms Humans Melanoma Mouth Neoplasms Mucositis Photons Precancerous Conditions Radiometry |
| description |
Boron neutron capture therapy (BNCT) is a treatment modality that combines different radiation qualities. Since the severity of biological damage following irradiation depends on the radiation type, a quantity different from absorbed dose is required to explain the effects observed in the clinical BNCT in terms of outcome compared with conventional photon radiation therapy. A new approach for calculating photon iso-effective doses in BNCT was introduced previously. The present work extends this model to include information from dose-response assessments in animal models and humans. Parameters of the model were determined for tumour and precancerous tissue using dose-response curves obtained from BNCT and photon studies performed in the hamster cheek pouch in vivo models of oral cancer and/or pre-cancer, and from head and neck cancer radiotherapy data with photons. To this end, suitable expressions of the dose-limiting Normal Tissue Complication and Tumour Control Probabilities for the reference radiation and for the mixed field BNCT radiation were developed. Pearson's correlation coefficients and p-values showed that TCP and NTCP models agreed with experimental data (with r > 0.87 and p-values >0.57). The photon iso-effective dose model was applied retrospectively to evaluate the dosimetry in tumours and mucosa for head and neck cancer patients treated with BNCT in Finland. Photon iso-effective doses in tumour were lower than those obtained with the standard RBE-weighted model (between 10% to 45%). The results also suggested that the probabilities of tumour control derived from photon iso-effective doses are more adequate to explain the clinical responses than those obtained with the RBE-weighted values. The dosimetry in the mucosa revealed that the photon iso-effective doses were about 30% to 50% higher than the corresponding RBE-weighted values. While the RBE-weighted doses are unable to predict mucosa toxicity, predictions based on the proposed model are compatible with the observed clinical outcome. The extension of the photon iso-effective dose model has allowed, for the first time, the determination of the photon iso-effective dose for unacceptable complications in the dose-limiting normal tissue. Finally, the formalism developed in this work to compute photon-equivalent doses can be applied to other therapies that combine mixed radiation fields, such as hadron therapy. © 2017 Institute of Physics and Engineering in Medicine. |
| format |
JOUR |
| author |
González, S.J. Pozzi, E.C.C. Monti Hughes, A. Provenzano, L. Koivunoro, H. Carando, D.G. Thorp, S.I. Casal, M.R. Bortolussi, S. Trivillin, V.A. Garabalino, M.A. Curotto, P. Heber, E.M. Santa Cruz, G.A. Kankaanranta, L. Joensuu, H. Schwint, A.E. |
| author_facet |
González, S.J. Pozzi, E.C.C. Monti Hughes, A. Provenzano, L. Koivunoro, H. Carando, D.G. Thorp, S.I. Casal, M.R. Bortolussi, S. Trivillin, V.A. Garabalino, M.A. Curotto, P. Heber, E.M. Santa Cruz, G.A. Kankaanranta, L. Joensuu, H. Schwint, A.E. |
| author_sort |
González, S.J. |
| title |
Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer |
| title_short |
Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer |
| title_full |
Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer |
| title_fullStr |
Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer |
| title_full_unstemmed |
Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer |
| title_sort |
photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: clinical application to boron neutron capture therapy for head and neck cancer |
| url |
http://hdl.handle.net/20.500.12110/paper_00319155_v62_n20_p7938_Gonzalez |
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